P21869

PR
Gene name
Protein name
Casein kinase II subunit alpha'
Names
CK II
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:415626
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

175-197 (Activation loop from InterPro)

Target domain

40-325 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P21869

Entry ID Method Resolution Chain Position Source
AF-P21869-F1 Predicted AlphaFoldDB

8 variants for P21869

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1060119778 19 L>P No Ensembl
rs1058566130 20 R>T No Ensembl
rs1058867112 21 S>R No Ensembl
rs1057812906 24 Y>N No Ensembl
rs739410990 209 M>R No Ensembl
rs731764665 218 S>G No Ensembl
rs738764258 315 T>A No Ensembl
rs739491257 320 M>V No Ensembl

No associated diseases with P21869

3 regional properties for P21869

Type Name Position InterPro Accession
domain DNA binding HTH domain, AraC-type 202 - 300 IPR018060
conserved_site HTH domain AraC-type, conserved site 252 - 294 IPR018062
domain AraC-type transcription regulator, ligand-binding domain 2 - 183 IPR032783

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PcG protein complex A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.
protein kinase CK2 complex A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein N-terminus binding Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

6 GO annotations of biological process

Name Definition
negative regulation of ubiquitin-dependent protein catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of chromosome separation Any process that modulates the frequency, rate or extent of chromosome separation.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19454 CKA2 Casein kinase II subunit alpha' Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15790 CKA1 Casein kinase II subunit alpha Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P20427 CSNK2A2 Casein kinase II subunit alpha' Bos taurus (Bovine) PR
P68400 CSNK2A1 Casein kinase II subunit alpha Homo sapiens (Human) PR
P19784 CSNK2A2 Casein kinase II subunit alpha' Homo sapiens (Human) PR
O64816 CKA4 Casein kinase II subunit alpha-4, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q08466 CKA2 Casein kinase II subunit alpha-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI
70 80 90 100 110 120
TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIINLID TVKDPVSKTP ALVFEYINNT
130 140 150 160 170 180
DFKQLYQILT DFDIRFYMYE LLKALDYCHS MGIMHRDVKP HNVMIDHQQK KLRLIDWGLA
190 200 210 220 230 240
EFYHPAQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRK EPFFHGQDNY
250 260 270 280 290 300
DQLVRIAKVL GTDELYGYLK KYHIELDPHF NDILGQHSRK RWENFIHSEN RHLVSPEVLD
310 320 330 340
LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPSSENA VLSSGLTTAR