AiPD: Autoinhibited Protein Database

P19784

Gene name	CSNK2A2 (CK2A2)
Protein name	Casein kinase II subunit alpha'
Names	CK II alpha'
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1459
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-60 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

175-197 (Activation loop from InterPro)

Target domain	40-325 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

33 structures for P19784

Entry ID	Method	Resolution	Chain	Position	Source
3E3B	X-ray	320 A	X	1-334	PDB
3OFM	X-ray	200 A	A	1-350	PDB
3U87	X-ray	290 A	A/B	327-350	PDB
5M4U	X-ray	219 A	A	1-350	PDB
5M56	X-ray	224 A	A/B	1-350	PDB
5OOI	X-ray	200 A	A/B	1-350	PDB
5Y9M	X-ray	201 A	A/X	1-334	PDB
5YF9	X-ray	189 A	B/X	1-334	PDB
5YWM	X-ray	194 A	X	1-334	PDB
6HMB	X-ray	104 A	A	1-350	PDB
6HMC	X-ray	103 A	A	1-350	PDB
6HMD	X-ray	100 A	A	1-350	PDB
6HMQ	X-ray	097 A	A	1-346	PDB
6L20	X-ray	309 A	A/D/G/J	1-333	PDB
6QY8	X-ray	170 A	A/B/C/D	1-335	PDB
6QY9	X-ray	150 A	A	1-335	PDB
6TE2	X-ray	092 A	A	1-350	PDB
6TEW	X-ray	108 A	A	1-350	PDB
6TGU	X-ray	083 A	A	1-350	PDB
7A1B	X-ray	129 A	A	1-350	PDB
7A1Z	X-ray	102 A	A	1-350	PDB
7A22	X-ray	101 A	A	1-350	PDB
7A2H	X-ray	101 A	A	1-350	PDB
7AT9	X-ray	105 A	A	1-350	PDB
7ATV	X-ray	098 A	A	1-350	PDB
7XYH	X-ray	204 A	A/B	1-334	PDB
8Q77	X-ray	125 A	A	1-350	PDB
8Q9S	X-ray	135 A	A	1-350	PDB
8QBU	X-ray	109 A	A	1-350	PDB
8QCD	X-ray	103 A	A	1-350	PDB
8QCG	X-ray	104 A	A/B	1-350	PDB
8QF1	X-ray	132 A	A/B	1-350	PDB
AF-P19784-F1	Predicted				AlphaFoldDB

138 variants for P19784

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1276382492 CA396143262	2	P>A		No	ClinGen TOPMed gnomAD
rs1276382492 CA396143259	2	P>S		No	ClinGen TOPMed gnomAD
CA8086212 rs761960574	3	G>D		No	ClinGen ExAC TOPMed gnomAD
CA396143228 rs1327124704	4	P>L		No	ClinGen gnomAD
CA396143222 rs1385598542	5	A>G		No	ClinGen gnomAD
CA8086211 rs774365294	5	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1396273832 CA396143149	11	R>Q		No	ClinGen gnomAD
rs763134466 CA8086209	12	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	14	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396143058 rs1474767631	18	S>G		No	ClinGen gnomAD
rs576968089 CA8086208	18	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1195162965 CA396143034	20	R>K		No	ClinGen gnomAD
rs1165057931 CA396143005	22	R>C		No	ClinGen gnomAD
rs1597130691 CA396142982	23	E>D		No	ClinGen Ensembl
CA281656792 rs867887217 COSM1189284	25	W>C	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
CA8086206 rs745740318	26	D>Y		No	ClinGen ExAC gnomAD
CA396142902 rs1256338649	29	A>G		No	ClinGen gnomAD
rs1304897203 CA396142866	32	P>S		No	ClinGen TOPMed
rs747744716 CA8086178	36	N>D		No	ClinGen ExAC gnomAD
TCGA novel	38	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396142676 rs1489690587	40	Y>*		No	ClinGen TOPMed
rs1470616474 CA396142622	46	L>F		No	ClinGen gnomAD
rs113595783 CA281656414	48	R>W		No	ClinGen Ensembl
rs746222418 CA8086175	50	K>R		No	ClinGen ExAC gnomAD
CA396142543 rs1434461489	53	E>D		No	ClinGen TOPMed
CA281656409 rs755082916	55	F>L		No	ClinGen Ensembl
TCGA novel	56	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA281656404 rs749158672	59	N>S		No	ClinGen TOPMed gnomAD
rs757751451 CA8086173	60	I>T		No	ClinGen ExAC gnomAD
rs752039831 CA8086172	62	N>S		No	ClinGen ExAC gnomAD
rs141110736 CA8086171	63	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758554247 CA8086169	64	E>D		No	ClinGen ExAC gnomAD
TCGA novel	66	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8086145 rs766137540	79	I>K		No	ClinGen ExAC gnomAD
rs922058971 CA281649217	81	R>Q		No	ClinGen Ensembl
CA396139703 rs1321409878	83	V>F		No	ClinGen gnomAD
CA396139668 rs1461119155	84	K>N		No	ClinGen gnomAD
rs1395549018 CA396139654	85	I>V		No	ClinGen gnomAD
CA396139608 rs1187368784	87	E>G		No	ClinGen TOPMed
rs1431525244 CA396139511	90	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8086143 rs750301809	90	R>H		No	ClinGen ExAC TOPMed gnomAD
CA396139502 rs750301809	90	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1395763592 CA396139406	94	N>S		No	ClinGen TOPMed
rs1437189490 CA396139390	95	I>V		No	ClinGen TOPMed
CA396139315 rs1187552611	98	L>M		No	ClinGen gnomAD
CA396139190 rs1597122741	101	T>I		No	ClinGen Ensembl
rs968510502 CA281649203	106	V>M		No	ClinGen TOPMed gnomAD
TCGA novel	108	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750167395 CA8086125	114	F>L		No	ClinGen ExAC TOPMed gnomAD
CA8086124 rs138081655	115	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs547345655 CA281646826	116	Y>C		No	ClinGen 1000Genomes
CA8086122 rs751520619	117	I>F		No	ClinGen ExAC gnomAD
CA396138174 rs1305423634	118	N>S		No	ClinGen gnomAD
CA396138138 rs1389880598	120	T>R		No	ClinGen gnomAD
rs1433940583 CA396135488	124	Q>H		No	ClinGen gnomAD
rs769274520 CA8086112	125	L>F		No	ClinGen ExAC gnomAD
rs749317833 CA8086111	128	I>F		No	ClinGen ExAC TOPMed gnomAD
rs749317833 CA396135424	128	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8086110 rs780233214	131	D>A		No	ClinGen ExAC gnomAD
CA8086109 rs769880764	132	F>L		No	ClinGen ExAC gnomAD
CA8086108 rs144995982	132	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA396135333 rs1377840811	133	D>G		No	ClinGen gnomAD
rs1336128000 CA396135319	134	I>T		No	ClinGen TOPMed
CA8086107 rs780916581	135	R>Q		No	ClinGen ExAC gnomAD
CA396135235 rs1453441068	139	Y>C		No	ClinGen gnomAD
rs746032185 CA8086091	146	D>H		No	ClinGen ExAC gnomAD
rs879123154 CA281633510	151	K>Q		No	ClinGen Ensembl
CA8086090 rs781398318	153	I>V		No	ClinGen ExAC gnomAD
TCGA novel	164	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396134241 rs1419394704	170	K>R		No	ClinGen gnomAD
TCGA novel	171	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	172	L>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396134104 rs1351945441	178	G>V		No	ClinGen gnomAD
VAR_040416 rs55911801 CA281632955	188	E>A		No	ClinGen UniProt dbSNP gnomAD
TCGA novel	188	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1195346315 CA396133844	196	R>G		No	ClinGen gnomAD
TCGA novel	203	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA281632938 rs964390881	206	D>E		No	ClinGen Ensembl
rs974586708 CA281632680	213	S>N		No	ClinGen Ensembl
CA396132825 rs1374823589	219	L>F		No	ClinGen gnomAD
CA281632672 rs914498045	219	L>V		No	ClinGen Ensembl
CA8086046 rs150003385	219	L>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA396132764 rs1174571175	224	A>G		No	ClinGen TOPMed
rs201815819 CA281632638	229	R>Q		No	ClinGen TOPMed gnomAD
rs1486182360 CA396132698	230	R>K		No	ClinGen gnomAD
CA396132634 rs1158151383	235	H>R		No	ClinGen gnomAD
TCGA novel	236	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755699042 CA8086043	238	D>N		No	ClinGen ExAC TOPMed gnomAD
CA8086042 rs527723255	240	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1214155978 CA396132581	240	Y>H		No	ClinGen TOPMed gnomAD
rs1367136506 CA396132469	246	I>V		No	ClinGen gnomAD
rs371309575 CA8086020	248	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1567463706 CA396132430	252	T>K		No	ClinGen Ensembl
CA8086018 rs754263768	257	G>V		No	ClinGen ExAC gnomAD
rs1419361114 CA396132289	264	I>V		No	ClinGen gnomAD
COSM386740 CA396132250 rs1451645931	267	D>N	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs756627324 CA396132212	269	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA396132218 rs1251533091	269	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA281632177 rs760578490	270	F>L		No	ClinGen gnomAD
rs375864630 CA8086015	271	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1435591271 CA396132178	272	D>G		No	ClinGen gnomAD
CA281631618 rs998635769	278	S>L		No	ClinGen Ensembl
rs752511537 CA8085985	279	R>Q		No	ClinGen ExAC gnomAD
rs1289137648 CA396132051	279	R>W		No	ClinGen gnomAD
CA396132030 rs1374223667	281	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA396132027 rs1465113121	281	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs951500034 CA281631594	289	E>D		No	ClinGen TOPMed
rs1398029204 CA396131880	294	V>I		No	ClinGen TOPMed
rs1243143862 CA396131865	295	S>T		No	ClinGen TOPMed gnomAD
CA8085983 rs759457020	296	P>L	Variant assessed as Somatic; 9.24e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs201664709 CA8085982	298	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs550840644 CA281631588	305	L>P		No	ClinGen 1000Genomes
TCGA novel	305	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396131753 rs1597109046	307	R>*		No	ClinGen Ensembl
CA8085981 rs755124535	307	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1310591338 CA396131726	309	D>N		No	ClinGen TOPMed
rs772756341 CA8085979	311	Q>R		No	ClinGen ExAC gnomAD
CA396131580 rs1255264484	315	T>A		No	ClinGen gnomAD
CA396131579 rs1255264484	315	T>S		No	ClinGen gnomAD
rs747830904 CA8085977	317	K>R		No	ClinGen ExAC TOPMed gnomAD
rs775784514 CA8085976	322	H>Q		No	ClinGen ExAC gnomAD
TCGA novel	326	Y>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs965309455 CA281630731	327	P>R		No	ClinGen Ensembl
rs539754676 CA8085955	327	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA396131318 rs1351765884	329	V>L		No	ClinGen TOPMed gnomAD
CA8085953 rs747552329	332	Q>H		No	ClinGen ExAC gnomAD
CA396131287 rs1162169662	333	S>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8085952 rs777939766	335	P>S		No	ClinGen ExAC gnomAD
rs1370067990 CA396131268	336	C>R		No	ClinGen gnomAD
CA8085951 rs772280375	336	C>Y		No	ClinGen ExAC gnomAD
CA8085950 rs748302134	338	D>Y		No	ClinGen ExAC gnomAD
rs1006567762 CA281630712	339	N>S		No	ClinGen TOPMed
CA396131243 rs1390575356	340	A>T		No	ClinGen gnomAD
rs755276523 CA8085948	344	S>T		No	ClinGen ExAC gnomAD
CA396131185 rs1409707784	346	L>F		No	ClinGen gnomAD
CA396131173 rs753544192	347	T>K		No	ClinGen ExAC gnomAD
CA8085947 rs753544192	347	T>M		No	ClinGen ExAC gnomAD
CA396131135 rs1250089462	351	R>R		No	ClinGen gnomAD

No associated diseases with P19784

1 regional properties for P19784

Type	Name	Position	InterPro Accession
conserved_site	UDP-glycosyltransferase family, conserved site	347 - 390	IPR035595

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Nucleus Cytoplasm	Interaction with SIRT6 prevents translocation into the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein kinase CK2 complex	A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein N-terminus binding	Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

14 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cerebral cortex development	The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
liver regeneration	The regrowth of lost or destroyed liver.
negative regulation of apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
negative regulation of ubiquitin-dependent protein catabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of protein targeting to mitochondrion	Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
regulation of autophagy of mitochondrion	Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of chromosome separation	Any process that modulates the frequency, rate or extent of chromosome separation.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
Wnt signaling pathway	The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P19454	CKA2	Casein kinase II subunit alpha'	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P15790	CKA1	Casein kinase II subunit alpha	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P20427	CSNK2A2	Casein kinase II subunit alpha'	Bos taurus (Bovine)	PR
P21869		Casein kinase II subunit alpha'	Gallus gallus (Chicken)	PR
P68400	CSNK2A1	Casein kinase II subunit alpha	Homo sapiens (Human)	PR
O64816	CKA4	Casein kinase II subunit alpha-4, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
Q08466	CKA2	Casein kinase II subunit alpha-2	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MPGPAAGSRA	RVYAEVNSLR	SREYWDYEAH	VPSWGNQDDY	QLVRKLGRGK	YSEVFEAINI
70	80	90	100	110	120
TNNERVVVKI	LKPVKKKKIK	REVKILENLR	GGTNIIKLID	TVKDPVSKTP	ALVFEYINNT
130	140	150	160	170	180
DFKQLYQILT	DFDIRFYMYE	LLKALDYCHS	KGIMHRDVKP	HNVMIDHQQK	KLRLIDWGLA
190	200	210	220	230	240
EFYHPAQEYN	VRVASRYFKG	PELLVDYQMY	DYSLDMWSLG	CMLASMIFRR	EPFFHGQDNY
250	260	270	280	290	300
DQLVRIAKVL	GTEELYGYLK	KYHIDLDPHF	NDILGQHSRK	RWENFIHSEN	RHLVSPEALD
310	320	330	340
LLDKLLRYDH	QQRLTAKEAM	EHPYFYPVVK	EQSQPCADNA	VLSSGLTAAR