O64816

PR
Gene name
CKA4
Protein name
Casein kinase II subunit alpha-4, chloroplastic
Names
CK2-alpha4, Plastid-targeted casein kinase 2 alpha, cpCK2alpha
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G23070
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

267-289 (Activation loop from InterPro)

Target domain

132-417 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O64816

Entry ID Method Resolution Chain Position Source
AF-O64816-F1 Predicted AlphaFoldDB

30 variants for O64816

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH13342540 5 P>H No 1000Genomes
ENSVATH01871994 6 C>W No 1000Genomes
tmp_2_9826852_G_A 7 T>I No 1000Genomes
tmp_2_9826829_G_T 15 R>S No 1000Genomes
tmp_2_9826822_G_C 17 A>G No 1000Genomes
tmp_2_9826790_G_A 28 L>F No 1000Genomes
ENSVATH05562751 30 F>C No 1000Genomes
tmp_2_9826759_C_T 38 R>K No 1000Genomes
ENSVATH05562749 42 L>F No 1000Genomes
tmp_2_9826663_T_A 70 H>L No 1000Genomes
ENSVATH14535955 74 Q>H No 1000Genomes
ENSVATH14535956 74 Q>K No 1000Genomes
ENSVATH05562744 76 S>L No 1000Genomes
tmp_2_9826642_C_G 77 R>P No 1000Genomes
tmp_2_9826629_T_A 81 K>N No 1000Genomes
ENSVATH00243104 99 P>Q No 1000Genomes
ENSVATH13342539 106 A>G No 1000Genomes
tmp_2_9826078_C_T 154 D>N No 1000Genomes
tmp_2_9825872_C_T 183 G>S No 1000Genomes
ENSVATH14535941 210 N>K No 1000Genomes
ENSVATH14535939 261 Q>H No 1000Genomes
ENSVATH01871990 261 Q>R No 1000Genomes
ENSVATH14535936 339 A>G No 1000Genomes
tmp_2_9824719_G_A 349 A>V No 1000Genomes
tmp_2_9824702_G_A 355 R>C No 1000Genomes
tmp_2_9824351_C_T 401 D>N No 1000Genomes
ENSVATH05562696 416 Y>F No 1000Genomes
tmp_2_9824182_G_A 427 R>C No 1000Genomes
tmp_2_9824178_G_T 428 T>K No 1000Genomes
ENSVATH05562695 430 R>H No 1000Genomes

No associated diseases with O64816

3 regional properties for O64816

Type Name Position InterPro Accession
domain Protein kinase domain 132 - 417 IPR000719
active_site Serine/threonine-protein kinase, active site 245 - 257 IPR008271
binding_site Protein kinase, ATP binding site 138 - 161 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

8 GO annotations of biological process

Name Definition
cellular response to abscisic acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
chloroplast-nucleus signaling pathway The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis.
negative regulation of seed germination Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of growth Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
regulation of photoperiodism, flowering Any process that modulates the frequency, rate or extent of photoperiodism, flowering.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19454 CKA2 Casein kinase II subunit alpha' Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P15790 CKA1 Casein kinase II subunit alpha Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P20427 CSNK2A2 Casein kinase II subunit alpha' Bos taurus (Bovine) PR
P21869 Casein kinase II subunit alpha' Gallus gallus (Chicken) PR
P19784 CSNK2A2 Casein kinase II subunit alpha' Homo sapiens (Human) PR
P68400 CSNK2A1 Casein kinase II subunit alpha Homo sapiens (Human) PR
Q08466 CKA2 Casein kinase II subunit alpha-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MALRPCTGFT ISSLRNASAA NNNLFSLLSF SSSSPAKRNL LLSSLQDNLR RFASSASLYR
70 80 90 100 110 120
QHLRNQQQQH QQQQQSRVKE KSETLAQKIG KSIRRAGAPS KARVYADVNV VRPKDYWDYE
130 140 150 160 170 180
SLAVQWGVQD DYEVVRKVGR GKYSEVFEGI HATDNEKCVI KILKPVKKKK IKREIKILQN
190 200 210 220 230 240
LCGGPNIVKL LDIVRDQQSK TPSLIFEHVN NKDFKVLYPT LSDYDVRYYI FELLKALDFC
250 260 270 280 290 300
HSRGIMHRDV KPHNVMIDHE QRKLRLIDWG LAEFYHPGKE YNVRVASRYF KGPELLVDLQ
310 320 330 340 350 360
DYDYSLDLWS LGCMFAGMIF RKEPFFYGHD NYDQLVKIAK VLGTDELNAY LNKYRIELDP
370 380 390 400 410 420
NLTSLVGRHS RKPWTKFINS ENQHLAVPEA VDFVDKLLRY DHQERPTAKE AMAHPYFYPI
430
RNAESSRTPR SQ