Q08299
PR
Gene name |
ENB1 (ARN4, YOL158C) |
Protein name |
Siderophore iron transporter ENB1 |
Names |
Enterobactin permease, Siderophore iron transporter ARN4 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOL158C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08299
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08299-F1 | Predicted | AlphaFoldDB |
24 variants for Q08299
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-21293 | 6 | H>Q | No | SGRP | |
| s15-21286 | 9 | N>D | No | SGRP | |
| s15-21254 | 19 | C>W | No | SGRP | |
| s15-21249 | 21 | S>N | No | SGRP | |
| s15-21118 | 65 | A>T | No | SGRP | |
| s15-20945 | 122 | I>M | No | SGRP | |
| s15-20888 | 141 | I>M | No | SGRP | |
| s15-20890 | 141 | I>V | No | SGRP | |
| s15-20854 | 153 | S>A | No | SGRP | |
| s15-20853 | 153 | S>C | No | SGRP | |
| s15-20845 | 156 | F>L | No | SGRP | |
| s15-20733 | 193 | F>S | No | SGRP | |
| s15-20556 | 252 | S>N | No | SGRP | |
| s15-20518 | 265 | Q>K | No | SGRP | |
| s15-20515 | 266 | T>A | No | SGRP | |
| s15-20483 | 276 | D>E | No | SGRP | |
| s15-20356 | 319 | G>S | No | SGRP | |
| s15-20338 | 325 | I>L | No | SGRP | |
| s15-20316 | 332 | K>R | No | SGRP | |
| s15-20035 | 426 | I>L | No | SGRP | |
| s15-19937 | 458 | I>M | No | SGRP | |
| s15-19909 | 468 | A>T | No | SGRP | |
| s15-19897 | 472 | H>Y | No | SGRP | |
| s15-19681 | 544 | E>* | No | SGRP |
No associated diseases with Q08299
1 regional properties for Q08299
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 62 - 576 | IPR020846 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| cellular bud membrane | The portion of the plasma membrane surrounding a cellular bud. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ferric-enterobactin transmembrane transporter activity | Enables the transfer of ferric-enterobactin from one side of a membrane to the other. |
| siderophore transmembrane transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| ferric-enterobactin import into cell | A process in which ferric-enterobactin, the iron-bound form of the siderophore enterobactin, is transported into the cell by specific cell surface receptors. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P33335 | SGE1 | Protein SGE1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P25596 | GEX1 | Glutathione exchanger 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P36173 | GEX2 | Glutathione exchanger 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P38731 | ARN1 | Siderophore iron transporter ARN1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q04301 | VBA1 | Vacuolar basic amino acid transporter 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q04602 | VBA4 | Vacuolar basic amino acid transporter 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLETDHSRND | NLDDKSTVCY | SEKTDSNVEK | STTSGLRRID | AVNKVLSDYS | SFTAFGVTFS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLKTALLVAL | FLQGYCTGLG | GQISQSIQTY | AANSFGKHSQ | VGSINTVKSI | VASVVAVPYA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RISDRFGRIE | CWIFALVLYT | IGEIISAATP | TFSGLFAGIV | IQQFGYSGFR | LLATALTGDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGLRDRTFAM | NIFLIPVIIN | TWVSGNIVSS | VAGNVAPYKW | RWGYGIFCII | VPISTLILVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PYVYAQYISW | RSGKLPPLKL | KEKGQTLRQT | LWKFADDINL | IGVILFTAFL | VLVLLPLTIA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GGATSKWREG | HIIAMIVVGG | CLGFIFLIWE | LKFAKNPFIP | RVYLGDPTIY | VALLMEFVWR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LGLQIELEYL | VTVLMVAFGE | STLSAQRIAQ | LYNFLQSCTN | IVVGIMLHFY | PHPKVFVVAG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLLGVIGMGL | LYKYRVVYDG | ISGLIGAEIV | VGIAGGMIRF | PMWTLVHAST | THNEMATVTG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLMSVYQIGD | AVGASIAGAI | WTQRLAKELI | QRLGSSLGMA | IYKSPLNYLK | KYPIGSEVRV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QMIESYSKIQ | RLLIIVSISF | AAFNAVLCFF | LRGFTVNKKQ | SLSAEEREKE | KLKIKQQSWL |
| RRVIGY |