P33335
Gene name |
SGE1 (NOR1, YPR198W, P9677.3) |
Protein name |
Protein SGE1 |
Names |
10-N-nonyl acridine orange resistance protein, Crystal violet resistance protein |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPR198W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P33335
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P33335-F1 | Predicted | AlphaFoldDB |
10 variants for P33335
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-934319 | 97 | A>V | No | SGRP | |
| s16-934645 | 206 | Y>H | No | SGRP | |
| s16-934730 | 234 | S>C | No | SGRP | |
| s16-934873 | 282 | S>P | No | SGRP | |
| s16-934880 | 284 | S>L | No | SGRP | |
| s16-934918 | 297 | L>M | No | SGRP | |
| s16-935179 | 384 | V>I | No | SGRP | |
| s16-935316 | 429 | D>E | No | SGRP | |
| s16-935428 | 467 | K>E | No | SGRP | |
| s16-935545 | 506 | N>D | No | SGRP |
No associated diseases with P33335
1 regional properties for P33335
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 10 - 535 | IPR020846 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P25596 | GEX1 | Glutathione exchanger 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q08299 | ENB1 | Siderophore iron transporter ENB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P36173 | GEX2 | Glutathione exchanger 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P38731 | ARN1 | Siderophore iron transporter ARN1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q04301 | VBA1 | Vacuolar basic amino acid transporter 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q04602 | VBA4 | Vacuolar basic amino acid transporter 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSTLSLTLC | VISLLLTLFL | AALDIVIVVT | LYDTIGIKFH | DFGNIGWLVT | GYALSNAVFM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLWGRLAEIL | GTKECLMISV | IVFEIGSLIS | ALSNSMATLI | SGRVVAGFGG | SGIESLAFVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTSIVRENHR | GIMITALAIS | YVIAEGVGPF | IGGAFNEHLS | WRWCFYINLP | IGAFAFIILA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FCNTSGEPHQ | KMWLPSKIKK | IMNYDYGELL | KASFWKNTFE | VLVFKLDMVG | IILSSAGFTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LMLGLSFGGN | NFPWNSGIII | CFFTVGPILL | LLFCAYDFHF | LSLSGLHYDN | KRIKPLLTWN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IASNCGIFTS | SITGFLSCFA | YELQSAYLVQ | LYQLVFKKKP | TLASIHLWEL | SIPAMIATMA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IAYLNSKYGI | IKPAIVFGVL | CGIVGSGLFT | LINGELSQSI | GYSILPGIAF | GSIFQATLLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SQVQITSDDP | DFQNKFIEVT | AFNSFAKSLG | FAFGGNMGAM | IFTASLKNQM | RSSQLNIPQF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TSVETLLAYS | TEHYDGPQSS | LSKFINTAIH | DVFYCALGCY | ALSFFFGIFT | SSKKTTISAK |
| KQQ |