AiPD: Autoinhibited Protein Database

Gene name	GEX1 (YCL073C, YCL70C/YCL71C/YCL73C)
Protein name	Glutathione exchanger 1
Names
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YCL073C
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-81 (Predicted disordered autoinhibitory region) PR

1-81 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P25596-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s03-8254	25	R>*	No	SGRP
s03-8229	33	T>M	No	SGRP
s03-8226	34	Y>F	No	SGRP
s03-8113	72	G>R	No	SGRP
s03-8008	107	V>I	No	SGRP
s03-7824	168	L>P	No	SGRP
s03-7633	232	I>V	No	SGRP
s03-7626	234	L>P	No	SGRP
s03-7486	281	L>V	No	SGRP
s03-7476	284	V>A	No	SGRP
s03-7396	311	T>P	No	SGRP
s03-7254	358	T>I	No	SGRP
s03-6873	485	G>A	No	SGRP
s03-6808	507	K>*	No	SGRP
s03-6747	527	S>N	No	SGRP
s03-6726	534	P>L	No	SGRP
s03-6633	565	T>K	No	SGRP
s03-6573	585	D>A	No	SGRP
s03-6540	596	I>T	No	SGRP
s03-6513	605	R>K	No	SGRP
s03-6499	610	N>D	No	SGRP
s03-6493	612	K>E	No	SGRP
s03-6489	613	L>S	No	SGRP

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P25596

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Vacuole membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell periphery	The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
vacuolar membrane	The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

Name	Definition
siderophore transmembrane transporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).
solute:proton antiporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out).
transmembrane transporter activity	Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Name	Definition
cellular iron ion homeostasis	Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
glutathione transmembrane transport	A process in which glutathione is transported across a membrane.
transmembrane transport	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P33335	SGE1	Protein SGE1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q08299	ENB1	Siderophore iron transporter ENB1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P36173	GEX2	Glutathione exchanger 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P38731	ARN1	Siderophore iron transporter ARN1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q04301	VBA1	Vacuolar basic amino acid transporter 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q04602	VBA4	Vacuolar basic amino acid transporter 4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR