Q04301
Gene name |
VBA1 (YMR088C, YM9582.13C) |
Protein name |
Vacuolar basic amino acid transporter 1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR088C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q04301
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q04301-F1 | Predicted | AlphaFoldDB |
4 variants for Q04301
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-444318 | 262 | A>S | No | SGRP | |
| s13-444279 | 275 | V>I | No | SGRP | |
| s13-443953 | 383 | F>L | No | SGRP | |
| s13-443519 | 528 | K>R | No | SGRP |
No associated diseases with Q04301
1 regional properties for Q04301
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 38 - 556 | IPR020846 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| basic amino acid transmembrane transporter activity | Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| basic amino acid transport | The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P33335 | SGE1 | Protein SGE1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P25596 | GEX1 | Glutathione exchanger 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q08299 | ENB1 | Siderophore iron transporter ENB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P36173 | GEX2 | Glutathione exchanger 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P38731 | ARN1 | Siderophore iron transporter ARN1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q04602 | VBA4 | Vacuolar basic amino acid transporter 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQTLDETSNL | LPPPEEAEAP | PLEQKFHEYN | LALPKFPILF | SLWLGSFLSS | LDSTIVANIM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRVAEEFSES | SKKQWIATSF | LLTNTAFQPL | YGKLSDITGR | KSALLTAQFF | FGLGCLLTCF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ARNVTEFSIA | RAICGIGAGG | LNAISSIAVS | DICTARERGV | YQGYANIVFG | FGQLLGAPLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVFIETIGWR | ALFGIQVPVI | MLCSVLAIKN | INIKLFHVPP | MKERYTLKNL | SRIDIFGSLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVATISGVLF | LCSSQLNKLY | LALFTIGSFI | VFILVERYYA | TEKILPFELL | TRSFCLSSAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TVISSFVVFG | EIFRSPIYLQ | LLQNISVTKT | GLFLIFPSIS | VAVGSLVTGW | VLRNTKINLA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HCAYQIIFGG | MIMQLLGLGL | GYFLLSHLNP | DYTIYDMLES | ITFRSNSIWW | KLIYVFASVL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VSFGYACLLV | ATLVSIVFTV | EKSQQGTMTG | VFYLWRSIGN | VLGASLTLVS | YENSLSSMLW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NYMFKTKRDD | EYHFTKKQYY | SLINDSSYLR | GPNFPTDIFV | RILDVYKKAF | LISYIPNIAL |
| 550 | 560 | ||||
| AAVGIVLSLY | LVKHTYKRSS | SS |