Q04602
Gene name |
VBA4 (YDR119W) |
Protein name |
Vacuolar basic amino acid transporter 4 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR119W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q04602
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q04602-F1 | Predicted | AlphaFoldDB |
29 variants for Q04602
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-688350 | 43 | R>G | No | SGRP | |
| s04-688429 | 69 | S>N | No | SGRP | |
| s04-688434 | 71 | Q>K | No | SGRP | |
| s04-688471 | 83 | D>G | No | SGRP | |
| s04-688510 | 96 | I>T | No | SGRP | |
| s04-688515 | 98 | D>N | No | SGRP | |
| s04-688527 | 102 | D>N | No | SGRP | |
| s04-688582 | 120 | L>H | No | SGRP | |
| s04-688599 | 126 | H>N | No | SGRP | |
| s04-688605 | 128 | A>T | No | SGRP | |
| s04-688686 | 155 | C>G | No | SGRP | |
| s04-688716 | 165 | P>S | No | SGRP | |
| s04-688782 | 187 | T>P | No | SGRP | |
| s04-688785 | 188 | S>T | No | SGRP | |
| s04-688797 | 192 | S>P | No | SGRP | |
| s04-688802 | 193 | L>F | No | SGRP | |
| s04-688816 | 198 | P>L | No | SGRP | |
| s04-688818 | 199 | S>P | No | SGRP | |
| s04-689094 | 291 | S>T | No | SGRP | |
| s04-689334 | 371 | S>G | No | SGRP | |
| s04-689400 | 393 | M>V | No | SGRP | |
| s04-689443 | 407 | A>V | No | SGRP | |
| s04-689523 | 434 | Y>H | No | SGRP | |
| s04-689529 | 436 | R>G | No | SGRP | |
| s04-689539 | 439 | P>L | No | SGRP | |
| s04-689737 | 505 | S>N | No | SGRP | |
| s04-690264 | 681 | L>I | No | SGRP | |
| s04-690500 | 759 | C>* | No | SGRP | |
| s04-690526 | 768 | S>F | No | SGRP |
No associated diseases with Q04602
1 regional properties for Q04602
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 251 - 758 | IPR020846 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| basic amino acid transmembrane transporter activity | Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| basic amino acid transport | The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P33335 | SGE1 | Protein SGE1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P25596 | GEX1 | Glutathione exchanger 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q08299 | ENB1 | Siderophore iron transporter ENB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P36173 | GEX2 | Glutathione exchanger 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P38731 | ARN1 | Siderophore iron transporter ARN1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q04301 | VBA1 | Vacuolar basic amino acid transporter 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKKDRQRKK | LREFAKLKNR | QRNLRKSVQT | LKNEVQREAK | VPRTSNQIAL | GNDKIEEINE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NSPLLSAPSK | QEEVSIPKAV | DIDTIDAQPL | HEGPKIDDSP | QDEVNSIKGK | PADKANEDDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPPSQHEACG | NSALQSSITD | FSDRSVSPLQ | SITSCNTPMS | EHELPVSSSN | SFERADDMPV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VQADNQTSSS | KSLHIVAPSP | EVPVSGDEIT | SYGYGSIPQS | IGDVENGLNP | PYVENTSSDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVHDLTRRRI | FSSCMCTYLF | FIAMDSSIIL | VIASKIASEF | HELWRLSLVI | SAYLLSNAIG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QLVFLKLSLI | SSVKLLLCIA | QFSFILGGYL | SWSSAHFWTF | IFARCVTGFG | GGSLIALKST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IMNRFSQKND | SRYSLSASMI | TFAMGVVIGP | FMMNLFDSSH | GSGWRNAFLI | PVPFCLVNAS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IMLADMYSVK | STLYGRPTPT | LWKRFKNTLL | SPDLYEILTL | TLFLLCFVQV | TSLDLTGLKN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NTMIQALLFS | VIIVCGILFF | LIETSDTYMN | SVISMSLQGD | KRLIWTMIGI | SFCFAALMCI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IPFGTTYFII | VLNLSTLQLA | ERLSPFFFSI | VLGYFSVSYF | WKSKGQNFLL | KFVLSGATLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LYVALMGVSL | NLPVWKQYIC | LSLPFLGSSM | ILTLLSNLYH | EYHEQRKSPI | SGSIVYCFGA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VGGTVGISLG | GYVFHKTLIK | LMHEKVMPFS | KQGYLKKDLL | KIIKHATESS | DWVHESAPKF |
| 730 | 740 | 750 | 760 | ||
| VFQTLIECYL | QACRNVFKLS | TLFFTITVVA | IFIFNRIHCR | SQNCLSLS |