P36173
Gene name |
GEX2 (YKR106W) |
Protein name |
Glutathione exchanger 2 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKR106W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P36173
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P36173-F1 | Predicted | AlphaFoldDB |
18 variants for P36173
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-661152 | 25 | R>* | No | SGRP | |
| s11-661582 | 168 | L>P | No | SGRP | |
| s11-661761 | 228 | T>A | No | SGRP | |
| s11-661920 | 281 | L>V | No | SGRP | |
| s11-661930 | 284 | V>A | No | SGRP | |
| s11-662010 | 311 | T>P | No | SGRP | |
| s11-662152 | 358 | T>I | No | SGRP | |
| s11-662311 | 411 | L>H | No | SGRP | |
| s11-662323 | 415 | G>E | No | SGRP | |
| s11-662400 | 441 | I>V | No | SGRP | |
| s11-662659 | 527 | S>N | No | SGRP | |
| s11-662680 | 534 | P>L | No | SGRP | |
| s11-662766 | 563 | T>A | No | SGRP | |
| s11-662787 | 570 | N>D | No | SGRP | |
| s11-662893 | 605 | R>K | No | SGRP | |
| s11-662907 | 610 | N>D | No | SGRP | |
| s11-662913 | 612 | K>E | No | SGRP | |
| s11-662917 | 613 | S>L | No | SGRP |
No associated diseases with P36173
No regional properties for P36173
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P36173 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| siderophore transmembrane transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). |
| solute:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| glutathione transmembrane transport | A process in which glutathione is transported across a membrane. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P33335 | SGE1 | Protein SGE1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P25596 | GEX1 | Glutathione exchanger 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q08299 | ENB1 | Siderophore iron transporter ENB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P38731 | ARN1 | Siderophore iron transporter ARN1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q04301 | VBA1 | Vacuolar basic amino acid transporter 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q04602 | VBA4 | Vacuolar basic amino acid transporter 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSSVVGASS | NKKSGIRQSC | EIIERERHSN | DDTYSMTSTF | FKLKENEIMS | AQFDSLKYKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLISTAFVCG | FGISLDYTLR | STYTGYATNS | YSEHSLLSTV | QVINAVVSVG | SQVVYSRLSD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HFGRLRLFLV | ATIFYIMGTI | IQSQATRLTM | YAAGSVFYNC | GYVGTNLLLT | LILSDFSSLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WRMFYQYASY | WPYIIIPWIS | GNIITAANPQ | KNWSWNIAMW | AFIYPLSTLP | IIFLILYMKY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSSKTAEWRS | LKEQARKERT | GGLFENLVFL | FWKLDIVGIL | LITVSLGCIL | VPLTLANETS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QKWHNSKIIA | TLVSGGCLFF | IFLYWEAKFA | KSPLLPFKLL | SDRGIWAPLG | VTFFNFFTFF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISCDYLYPVL | LVSMKESSTS | AARIVNLPDF | VAATASPFYS | LLVAKTRKLK | LSVIGGCAAW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MVCMGLFYKY | RGGSGSHEGV | IAASVIMGLS | GLLCSNSVIV | ILQAMTTHSR | MAVITGIQYT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FSKLGAAIGA | SVSGAIWTQT | MPNQLYKNLG | NDTLAEIAYA | SPYTFISDYP | WGSPERDAVV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ESYRYVQRII | MTVGLACTVP | FFTFTMFMRN | PELIDKATHE | EFTEDGLVVL | PDEENIFSQI |
| 610 | |||||
| KALFRHNRSN | KKSGC |