Q06327
PR
Gene name |
LOX1 |
Protein name |
Linoleate 9S-lipoxygenase 1 |
Names |
Lipoxygenase 1, AtLOX1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G55020 |
EC number |
1.13.11.58: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q06327
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8I6Y | X-ray | 326 A | A/B | 1-859 | PDB |
| AF-Q06327-F1 | Predicted | AlphaFoldDB |
68 variants for Q06327
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH04965612 | 2 | F>I | No | 1000Genomes | |
| ENSVATH04965613 | 6 | R>G | No | 1000Genomes | |
| ENSVATH04965614 | 6 | R>M | No | 1000Genomes | |
| ENSVATH04965615 | 9 | L>F | No | 1000Genomes | |
| ENSVATH13576571 | 12 | G>S | No | 1000Genomes | |
| tmp_1_20525840_G_A | 15 | E>K | No | 1000Genomes | |
| ENSVATH04965617 | 22 | K>E | No | 1000Genomes | |
| tmp_1_20525915_G_A | 40 | A>T | No | 1000Genomes | |
| tmp_1_20525945_C_A | 50 | L>I | No | 1000Genomes | |
| tmp_1_20525953_C_A | 52 | N>K | No | 1000Genomes | |
| tmp_1_20525978_T_A | 61 | S>T | No | 1000Genomes | |
| tmp_1_20525988_C_T | 64 | T>I | No | 1000Genomes | |
| tmp_1_20525990_G_T | 65 | D>Y | No | 1000Genomes | |
| ENSVATH14319975 | 76 | K>N | No | 1000Genomes | |
| tmp_1_20527298_C_A | 86 | T>K | No | 1000Genomes | |
| ENSVATH13576641 | 89 | S>L | No | 1000Genomes | |
| ENSVATH04965660 | 105 | T>S | No | 1000Genomes | |
| ENSVATH14319976 | 107 | F>I | No | 1000Genomes | |
| tmp_1_20527373_G_A | 111 | G>E | No | 1000Genomes | |
| ENSVATH13576642 | 114 | L>V | No | 1000Genomes | |
| tmp_1_20527408_T_G | 123 | F>V | No | 1000Genomes | |
| ENSVATH04965661 | 140 | H>N | No | 1000Genomes | |
| ENSVATH04965661 | 140 | H>Y | No | 1000Genomes | |
| tmp_1_20527496_A_G | 152 | H>R | No | 1000Genomes | |
| tmp_1_20527680_G_C | 181 | E>Q | No | 1000Genomes | |
| ENSVATH14319977 | 204 | Y>F | No | 1000Genomes | |
| tmp_1_20527776_A_C | 213 | K>Q | No | 1000Genomes | |
| tmp_1_20527791_G_A | 218 | V>I | No | 1000Genomes | |
| ENSVATH13576655 | 236 | K>Q | No | 1000Genomes | |
| ENSVATH04965676 | 254 | L>I | No | 1000Genomes | |
| tmp_1_20527971_A_T | 278 | K>* | No | 1000Genomes | |
| ENSVATH13576657 | 311 | E>D | No | 1000Genomes | |
| ENSVATH13576658 | 324 | I>L | No | 1000Genomes | |
| ENSVATH04965686 | 345 | L>I | No | 1000Genomes | |
| tmp_1_20528307_C_A | 362 | T>K | No | 1000Genomes | |
| ENSVATH13576662 | 408 | I>M | No | 1000Genomes | |
| tmp_1_20528556_A_C | 416 | T>P | No | 1000Genomes | |
| tmp_1_20528659_G_A | 425 | R>K | No | 1000Genomes | |
| tmp_1_20528719_C_G | 445 | T>S | No | 1000Genomes | |
| ENSVATH00098120 | 473 | L>F | No | 1000Genomes | |
| tmp_1_20528844_G_C | 487 | V>L | No | 1000Genomes | |
| tmp_1_20528871_G_A | 496 | D>N | No | 1000Genomes | |
| ENSVATH04965709 | 553 | R>C | No | 1000Genomes | |
| tmp_1_20529150_G_T | 562 | A>S | No | 1000Genomes | |
| ENSVATH04965714 | 593 | N>H | No | 1000Genomes | |
| tmp_1_20529247_A_G | 594 | H>R | No | 1000Genomes | |
| ENSVATH14319979 | 598 | P>S | No | 1000Genomes | |
| ENSVATH00098127 | 613 | V>I | No | 1000Genomes | |
| ENSVATH13576697 | 616 | P>L | No | 1000Genomes | |
| ENSVATH01372271 | 656 | I>T | No | 1000Genomes | |
| ENSVATH04965723 | 662 | T>S | No | 1000Genomes | |
| ENSVATH14319980 | 671 | K>R | No | 1000Genomes | |
| tmp_1_20529589_G_A | 676 | E>K | No | 1000Genomes | |
| tmp_1_20529592_G_A | 677 | G>S | No | 1000Genomes | |
| ENSVATH04965725 | 682 | K>M | No | 1000Genomes | |
| tmp_1_20529610_T_G | 683 | S>A | No | 1000Genomes | |
| tmp_1_20529611_C_T | 683 | S>L | No | 1000Genomes | |
| ENSVATH04965726 | 685 | P>T | No | 1000Genomes | |
| ENSVATH04965727 | 697 | V>A | No | 1000Genomes | |
| tmp_1_20529734_A_T | 724 | Y>F | No | 1000Genomes | |
| tmp_1_20529748_C_G | 729 | P>A | No | 1000Genomes | |
| tmp_1_20529778_G_A | 739 | E>K | No | 1000Genomes | |
| ENSVATH14319982 | 765 | T>A | No | 1000Genomes | |
| tmp_1_20529910_G_A | 783 | V>I | No | 1000Genomes | |
| ENSVATH13576700 | 801 | E>D | No | 1000Genomes | |
| tmp_1_20530051_A_G | 830 | T>A | No | 1000Genomes | |
| ENSVATH04965735 | 843 | S>T | No | 1000Genomes | |
| tmp_1_20530112_G_T | 850 | G>V | No | 1000Genomes |
No associated diseases with Q06327
5 regional properties for Q06327
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PLAT/LH2 domain | 19 - 162 | IPR001024 |
| domain | Lipoxygenase, C-terminal | 164 - 859 | IPR013819 |
| binding_site | Lipoxygenase, iron binding site | 514 - 528 | IPR020833 |
| conserved_site | Lipoxygenase, conserved site | 541 - 551 | IPR020834 |
| domain | Plant lipoxygenase, PLAT/LH2 domain | 19 - 162 | IPR042057 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.58 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| linoleate 9S-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate. |
| metal ion binding | Binding to a metal ion. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| lateral root formation | The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper. |
| lipid oxidation | The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. |
| oxylipin biosynthetic process | The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. |
| response to abscisic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. |
| response to jasmonic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. |
| root development | The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P16050 | ALOX15 | Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (Human) | PR |
| P38419 | CM-LOX1 | Lipoxygenase 7, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| P09186 | LOX1.3 | Seed linoleate 9S-lipoxygenase-3 | Glycine max (Soybean) (Glycine hispida) | PR |
| P38418 | LOX2 | Lipoxygenase 2, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNX8 | LOX4 | Lipoxygenase 4, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUW0 | LOX5 | Linoleate 9S-lipoxygenase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P38415 | LOX1.1 | Linoleate 9S-lipoxygenase A | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFGELRDLLT | GGGNETTTKK | VKGTVVLMKK | NVLDFNDFNA | SFLDRLHEFL | GNKITLRLVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SDVTDSENGS | KGKLGKAAHL | EDWITTITSL | TAGESAFKVT | FDYETDFGYP | GAFLIRNSHF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEFLLKSLTL | EDVPGHGRVH | YICNSWIYPA | KHYTTDRVFF | SNKTYLPHET | PATLLKYREE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELVSLRGTGE | GELKEWDRVY | DYAYYNDLGV | PPKNPRPVLG | GTQEYPYPRR | GRTGRKPTKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DPQTESRLPI | TSSLDIYVPR | DERFGHLKMS | DFLAYALKAI | AQFIQPALEA | VFDDTPKEFD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SFEDVLKIYE | EGIDLPNQAL | IDSIVKNIPL | EMLKEIFRTD | GQKFLKFPVP | QVIKEDKTAW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RTDEEFAREM | LAGLNPVVIQ | LLKEFPPKSK | LDSESYGNQN | STITKSHIEH | NLDGLTVEEA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LEKERLFILD | HHDTLMPYLG | RVNTTTTKTY | ASRTLLFLKD | DGTLKPLVIE | LSLPHPNGDK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FGAVSEVYTP | GEGVYDSLWQ | LAKAFVGVND | SGNHQLISHW | MQTHASIEPF | VIATNRQLSV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LHPVFKLLEP | HFRDTMNINA | LARQILINGG | GIFEITVFPS | KYAMEMSSFI | YKNHWTFPDQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ALPAELKKRG | MAVEDPEAPH | GLRLRIKDYP | YAVDGLEVWY | AIESWVRDYI | FLFYKIEEDI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QTDTELQAWW | KEVREEGHGD | KKSEPWWPKM | QTREELVESC | TIIIWVASAL | HAAVNFGQYP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VAGYLPNRPT | ISRQYMPKEN | TPEFEELEKN | PDKVFLKTIT | AQLQTLLGIS | LIEILSTHSS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DEVYLGQRDS | KEWAAEKEAL | EAFEKFGEKV | KEIEKNIDER | NDDETLKNRT | GLVKMPYTLL |
| 850 | |||||
| FPSSEGGVTG | RGIPNSVSI |