Q9FNX8
PR
Gene name |
LOX4 (LOX3, At1g72520, F28P22.29, T10D10.1) |
Protein name |
Lipoxygenase 4, chloroplastic |
Names |
AtLOX4, LOX3-like protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G72520 |
EC number |
1.13.11.12: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FNX8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FNX8-F1 | Predicted | AlphaFoldDB |
65 variants for Q9FNX8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05132914 | 23 | P>S | No | 1000Genomes | |
| ENSVATH00139419 | 25 | H>Q | No | 1000Genomes | |
| ENSVATH05132915 | 31 | K>N | No | 1000Genomes | |
| ENSVATH01525699 | 33 | K>R | No | 1000Genomes | |
| ENSVATH01525700 | 40 | S>T | No | 1000Genomes | |
| ENSVATH05132916 | 47 | R>T | No | 1000Genomes | |
| ENSVATH01525701 | 49 | M>L | No | 1000Genomes | |
| ENSVATH05132917 | 54 | S>P | No | 1000Genomes | |
| tmp_1_27308777_G_A | 56 | G>D | No | 1000Genomes | |
| ENSVATH00139420 | 62 | S>T | No | 1000Genomes | |
| ENSVATH05132918 | 68 | T>A | No | 1000Genomes | |
| tmp_1_27308833_G_T | 75 | G>C | No | 1000Genomes | |
| ENSVATH01525703 | 81 | E>Q | No | 1000Genomes | |
| tmp_1_27308860_G_A | 84 | E>K | No | 1000Genomes | |
| ENSVATH13797717 | 94 | A>V | No | 1000Genomes | |
| ENSVATH00139422 | 130 | M>I | No | 1000Genomes | |
| tmp_1_27309002_G_A | 131 | S>N | No | 1000Genomes | |
| ENSVATH14473425 | 148 | V>D | No | 1000Genomes | |
| tmp_1_27309188_G_T | 149 | L>F | No | 1000Genomes | |
| tmp_1_27309268_G_A | 176 | G>D | No | 1000Genomes | |
| tmp_1_27309267_G_A | 176 | G>S | No | 1000Genomes | |
| tmp_1_27309279_G_A | 180 | A>T | No | 1000Genomes | |
| ENSVATH05132926 | 181 | I>M | No | 1000Genomes | |
| ENSVATH05132928 | 204 | G>A | No | 1000Genomes | |
| ENSVATH13797722 | 225 | I>F | No | 1000Genomes | |
| ENSVATH01525713 | 226 | L>F | No | 1000Genomes | |
| ENSVATH13797725 | 257 | K>N | No | 1000Genomes | |
| ENSVATH05132934 | 291 | G>S | No | 1000Genomes | |
| ENSVATH05132935 | 294 | F>Y | No | 1000Genomes | |
| ENSVATH01525726 | 313 | S>A | No | 1000Genomes | |
| tmp_1_27310065_A_C | 381 | K>T | No | 1000Genomes | |
| ENSVATH01525728 | 384 | F>L | No | 1000Genomes | |
| tmp_1_27310778_G_C | 458 | E>Q | No | 1000Genomes | |
| ENSVATH01525735 | 472 | H>Q | No | 1000Genomes | |
| ENSVATH14473432 | 473 | I>N | No | 1000Genomes | |
| ENSVATH01525736 | 474 | I>T | No | 1000Genomes | |
| ENSVATH01525737 | 481 | T>N | No | 1000Genomes | |
| ENSVATH13797739 | 484 | Q>E | No | 1000Genomes | |
| ENSVATH00139435 | 488 | T>M | No | 1000Genomes | |
| ENSVATH05132952 | 492 | F>L | No | 1000Genomes | |
| ENSVATH05132953 | 493 | M>I | No | 1000Genomes | |
| ENSVATH13797749 | 498 | D>E | No | 1000Genomes | |
| ENSVATH01525742 | 546 | N>K | No | 1000Genomes | |
| tmp_1_27311142_G_C | 548 | K>N | No | 1000Genomes | |
| tmp_1_27311143_T_G | 549 | S>A | No | 1000Genomes | |
| ENSVATH00139436 | 561 | S>F | No | 1000Genomes | |
| tmp_1_27311255_G_T | 586 | W>L | No | 1000Genomes | |
| ENSVATH01525746 | 648 | Y>F | No | 1000Genomes | |
| tmp_1_27311843_G_A | 679 | V>I | No | 1000Genomes | |
| ENSVATH05132964 | 686 | H>L | No | 1000Genomes | |
| tmp_1_27311873_A_C | 689 | K>Q | No | 1000Genomes | |
| ENSVATH00139441 | 693 | E>A | No | 1000Genomes | |
| ENSVATH05132965 | 693 | E>D | No | 1000Genomes | |
| tmp_1_27311948_A_G | 714 | T>A | No | 1000Genomes | |
| ENSVATH13797756 | 717 | E>D | No | 1000Genomes | |
| ENSVATH01525762 | 721 | A>P | No | 1000Genomes | |
| ENSVATH13797757 | 722 | N>S | No | 1000Genomes | |
| ENSVATH13797759 | 745 | A>G | No | 1000Genomes | |
| ENSVATH01525765 | 765 | V>I | No | 1000Genomes | |
| ENSVATH14473475 | 857 | P>L | No | 1000Genomes | |
| ENSVATH00139445 | 875 | A>V | No | 1000Genomes | |
| ENSVATH05132969 | 876 | E>D | No | 1000Genomes | |
| tmp_1_27312482_A_T | 892 | S>C | No | 1000Genomes | |
| ENSVATH00139446 | 892 | S>R | No | 1000Genomes | |
| ENSVATH05132971 | 893 | R>C | No | 1000Genomes |
No associated diseases with Q9FNX8
1 regional properties for Q9FNX8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 45 - 472 | IPR017452 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.12 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| linoleate 13S-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. |
| metal ion binding | Binding to a metal ion. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| anther dehiscence | The dehiscence of an anther to release the pollen grains contained within it. |
| anther development | The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure. |
| fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| lipid oxidation | The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. |
| oxylipin biosynthetic process | The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. |
| pollen development | The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| response to ozone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
| stamen filament development | The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P16050 | ALOX15 | Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (Human) | PR |
| P38419 | CM-LOX1 | Lipoxygenase 7, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| P09186 | LOX1.3 | Seed linoleate 9S-lipoxygenase-3 | Glycine max (Soybean) (Glycine hispida) | PR |
| P38418 | LOX2 | Lipoxygenase 2, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q06327 | LOX1 | Linoleate 9S-lipoxygenase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUW0 | LOX5 | Linoleate 9S-lipoxygenase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALANEIMGS | RLIFERSSSL | ASPFHSRFSI | KKKTQRTQFS | INPFDPRPMR | AVNSSGVVAA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ISEDLVKTLR | ISTVGRKQEK | EEEEEKSVKF | KVRAVATVRN | KNKEDFKETL | VKHLDAFTDK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IGRNVVLELM | STQVDPKTNE | PKKSKAAVLK | DWSKKSNSKA | ERVHYTAEFT | VDSAFGSPGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ITVTNKHQKE | FFLESITIEG | FACGPVHFPC | NSWVQSQKDH | PSKRILFTNQ | PYLPSETPSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRTLREKELE | NLRGNGKGER | KLSDRIYDYD | VYNDIGNPDI | SRELARPTLG | GREFPYPRRC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RTGRSSTDTD | MMSERRVEKP | LPMYVPRDEQ | FEESKQNTFA | ACRLKAVLHN | LIPSLKASIL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEDFANFGEI | DSLYKEGLLL | KLGFQDDMFK | KFPLPKIVTT | LQKSSEGLLR | YDTPKIVSKD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KYAWLRDDEF | ARQAIAGINP | VNIERVTSYP | PVSNLDPEIY | GPGLHSALTE | DHIIGQLDGL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TVQQALETNR | LFMVDYHDIY | LPFLDRINAL | DGRKAYATRT | ILFLTRLGTL | KPIAIELSLP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SQSSSNQKSK | RVVTPPVDAT | SNWMWQLAKA | HVGSNDAGVH | QLVNHWLRTH | ACLEPFILAA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HRQLSAMHPI | FKLLDPHMRY | TLEINAVARQ | TLISADGVIE | SCFTAGQYGL | EISSAAYKNK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WRFDMEGLPA | DLIRRGMAVP | DPTQPHGLKL | LVEDYPYAND | GLLLWSAIQT | WVRTYVERYY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ANSNLIQTDT | ELQAWYSESI | NVGHADHRDA | EWWPKLSTVE | DLVSVITTII | WLASAQHAAL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NFGQYPYGGY | VPNRPPLMRR | LIPDESDPEF | TSFIEDPQKY | FFSSMPSLLQ | TTKFMAVVDT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LSTHSPDEEY | IGERQQPSIW | TGDAEIVDAF | YGFSAEIGRI | EKEIDKRNRD | PSRRNRCGAG |
| 910 | 920 | ||||
| VLPYELMAPS | SEPGVTCRGV | PNSVSI |