P38418
PR
Gene name |
LOX2 (At3g45140, T14D3.80) |
Protein name |
Lipoxygenase 2, chloroplastic |
Names |
AtLOX2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G45140 |
EC number |
1.13.11.12: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38418
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38418-F1 | Predicted | AlphaFoldDB |
75 variants for P38418
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00399390 | 14 | N>S | No | 1000Genomes | |
| ENSVATH12493335 | 20 | S>R | No | 1000Genomes | |
| ENSVATH06223791 | 23 | F>L | No | 1000Genomes | |
| tmp_3_16525512_C_A | 26 | Q>K | No | 1000Genomes | |
| ENSVATH02430490 | 28 | A>T | No | 1000Genomes | |
| tmp_3_16525525_T_C | 30 | I>T | No | 1000Genomes | |
| ENSVATH02430491 | 32 | P>S | No | 1000Genomes | |
| tmp_3_16525584_T_A | 50 | C>S | No | 1000Genomes | |
| tmp_3_16525596_G_A | 54 | A>T | No | 1000Genomes | |
| ENSVATH02430492 | 64 | N>S | No | 1000Genomes | |
| ENSVATH02430493 | 65 | T>I | No | 1000Genomes | |
| ENSVATH12493338 | 78 | Y>C | No | 1000Genomes | |
| tmp_3_16525678_C_T | 81 | A>V | No | 1000Genomes | |
| ENSVATH02430494 | 111 | I>V | No | 1000Genomes | |
| ENSVATH06223794 | 113 | A>T | No | 1000Genomes | |
| ENSVATH02430495 | 114 | K>T | No | 1000Genomes | |
| tmp_3_16526124_C_T | 120 | T>M | No | 1000Genomes | |
| tmp_3_16526129_G_A | 122 | E>K | No | 1000Genomes | |
| tmp_3_16526154_C_T | 130 | A>V | No | 1000Genomes | |
| ENSVATH06223801 | 131 | E>D | No | 1000Genomes | |
| ENSVATH00399393 | 140 | E>V | No | 1000Genomes | |
| ENSVATH00399395 | 151 | G>E | No | 1000Genomes | |
| ENSVATH12493399 | 167 | G>V | No | 1000Genomes | |
| ENSVATH02430531 | 177 | I>L | No | 1000Genomes | |
| ENSVATH02430531 | 177 | I>V | No | 1000Genomes | |
| tmp_3_16526324_C_T | 187 | P>S | No | 1000Genomes | |
| ENSVATH06223809 | 190 | V>A | No | 1000Genomes | |
| tmp_3_16526336_G_A | 191 | D>N | No | 1000Genomes | |
| tmp_3_16526382_C_T | 206 | S>F | No | 1000Genomes | |
| ENSVATH00399400 | 207 | Q>E | No | 1000Genomes | |
| ENSVATH12493403 | 221 | E>K | No | 1000Genomes | |
| ENSVATH06223815 | 244 | D>H | No | 1000Genomes | |
| ENSVATH00399405 | 256 | P>L | No | 1000Genomes | |
| ENSVATH00399406 | 267 | T>A | No | 1000Genomes | |
| ENSVATH12493468 | 277 | G>D | No | 1000Genomes | |
| tmp_3_16526615_G_A | 284 | D>N | No | 1000Genomes | |
| tmp_3_16526622_C_T | 286 | S>F | No | 1000Genomes | |
| ENSVATH06223823 | 363 | L>M | No | 1000Genomes | |
| ENSVATH14363557 | 376 | D>N | No | 1000Genomes | |
| tmp_3_16526918_G_A | 385 | V>I | No | 1000Genomes | |
| ENSVATH02430553 | 389 | R>K | No | 1000Genomes | |
| ENSVATH12493586 | 423 | S>C | No | 1000Genomes | |
| tmp_3_16527483_C_T | 427 | P>S | No | 1000Genomes | |
| tmp_3_16527489_G_A | 429 | V>I | No | 1000Genomes | |
| ENSVATH12493588 | 449 | N>T | No | 1000Genomes | |
| tmp_3_16527677_G_A | 463 | V>M | No | 1000Genomes | |
| ENSVATH02430589 | 481 | N>D | No | 1000Genomes | |
| tmp_3_16528323_G_C | 627 | G>A | No | 1000Genomes | |
| ENSVATH12493664 | 629 | L>Q | No | 1000Genomes | |
| tmp_3_16528343_C_G | 634 | Q>E | No | 1000Genomes | |
| ENSVATH12493704 | 651 | K>R | No | 1000Genomes | |
| tmp_3_16528499_G_A | 653 | A>T | No | 1000Genomes | |
| tmp_3_16528579_A_C | 679 | E>D | No | 1000Genomes | |
| tmp_3_16528600_A_C | 686 | K>N | No | 1000Genomes | |
| ENSVATH06223894 | 687 | H>Y | No | 1000Genomes | |
| ENSVATH06223897 | 692 | E>D | No | 1000Genomes | |
| ENSVATH06223898 | 693 | E>G | No | 1000Genomes | |
| ENSVATH00399425 | 709 | R>Q | No | 1000Genomes | |
| tmp_3_16528697_G_A | 719 | E>K | No | 1000Genomes | |
| ENSVATH06223901 | 724 | V>I | No | 1000Genomes | |
| ENSVATH12493708 | 726 | K>R | No | 1000Genomes | |
| ENSVATH06223907 | 769 | I>T | No | 1000Genomes | |
| tmp_3_16528855_G_A | 771 | M>I | No | 1000Genomes | |
| tmp_3_16528880_G_A | 780 | A>T | No | 1000Genomes | |
| ENSVATH12493713 | 787 | S>T | No | 1000Genomes | |
| ENSVATH06223910 | 794 | K>R | No | 1000Genomes | |
| ENSVATH06223913 | 826 | Q>K | No | 1000Genomes | |
| ENSVATH12493747 | 828 | A>P | No | 1000Genomes | |
| ENSVATH12493748 | 834 | P>H | No | 1000Genomes | |
| ENSVATH06223915 | 835 | V>A | No | 1000Genomes | |
| ENSVATH12493749 | 835 | V>I | No | 1000Genomes | |
| tmp_3_16529058_C_T | 839 | A>V | No | 1000Genomes | |
| ENSVATH06223916 | 842 | R>K | No | 1000Genomes | |
| tmp_3_16529118_T_C | 859 | V>A | No | 1000Genomes | |
| ENSVATH12493751 | 883 | H>Y | No | 1000Genomes |
No associated diseases with P38418
4 regional properties for P38418
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aldo/keto reductase, conserved site | 39 - 56 | IPR018170-1 |
| conserved_site | Aldo/keto reductase, conserved site | 145 - 162 | IPR018170-2 |
| conserved_site | Aldo/keto reductase, conserved site | 261 - 276 | IPR018170-3 |
| domain | NADP-dependent oxidoreductase domain | 17 - 291 | IPR023210 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.12 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast envelope | The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| chloroplast thylakoid membrane | The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| linoleate 13S-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. |
| metal ion binding | Binding to a metal ion. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
| salicylic acid binding | Binding to salicylic acid. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| green leaf volatile biosynthetic process | The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid. |
| jasmonic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative. |
| lipid oxidation | The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. |
| oxylipin biosynthetic process | The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. |
| response to bacterium | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
| response to fungus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. |
| response to herbivore | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore. |
| response to jasmonic acid | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P16050 | ALOX15 | Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (Human) | PR |
| P38419 | CM-LOX1 | Lipoxygenase 7, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| P09186 | LOX1.3 | Seed linoleate 9S-lipoxygenase-3 | Glycine max (Soybean) (Glycine hispida) | PR |
| Q06327 | LOX1 | Linoleate 9S-lipoxygenase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNX8 | LOX4 | Lipoxygenase 4, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LUW0 | LOX5 | Linoleate 9S-lipoxygenase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYCRESLSSL | QTLNVAKSLS | SLFPKQSALI | NPISAGRRNN | LPRPNLRRRC | KVTASRANIE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QEGNTVKEPI | QNIKVKGYIT | AQEEFLEGIT | WSRGLDDIAD | IRGRSLLVEL | ISAKTDQRIT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VEDYAQRVWA | EAPDEKYECE | FEMPEDFGPV | GAIKIQNQYH | RQLFLKGVEL | KLPGGSITFT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CESWVAPKSV | DPTKRIFFSD | KSYLPSQTPE | PLKKYRKEEL | ETLQGKNREE | VGEFTKFERI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YDYDVYNDVG | DPDNDPELAR | PVIGGLTHPY | PRRCKTGRKP | CETDPSSEQR | YGGEFYVPRD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EEFSTAKGTS | FTGKAVLAAL | PSIFPQIESV | LLSPQEPFPH | FKAIQNLFEE | GIQLPKDAGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPLLPRIIKA | LGEAQDDILQ | FDAPVLINRD | RFSWLRDDEF | ARQTLAGLNP | YSIQLVEEWP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LISKLDPAVY | GDPTSLITWE | IVEREVKGNM | TVDEALKNKR | LFVLDYHDLL | LPYVNKVREL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NNTTLYASRT | LFFLSDDSTL | RPVAIELTCP | PNINKPQWKQ | VFTPGYDATS | CWLWNLAKTH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AISHDAGYHQ | LISHWLRTHA | CTEPYIIAAN | RQLSAMHPIY | RLLHPHFRYT | MEINARARQS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LVNGGGIIET | CFWPGKYALE | LSSAVYGKLW | RFDQEGLPAD | LIKRGLAEED | KTAEHGVRLT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IPDYPFANDG | LILWDAIKEW | VTDYVKHYYP | DEELITSDEE | LQGWWSEVRN | IGHGDKKDEP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| WWPVLKTQDD | LIGVVTTIAW | VTSGHHAAVN | FGQYGYGGYF | PNRPTTTRIR | MPTEDPTDEA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LKEFYESPEK | VLLKTYPSQK | QATLVMVTLD | LLSTHSPDEE | YIGEQQEASW | ANEPVINAAF |
| 850 | 860 | 870 | 880 | 890 | |
| ERFKGKLQYL | EGVIDERNVN | ITLKNRAGAG | VVKYELLKPT | SEHGVTGMGV | PYSISI |