Q9LUW0
PR
Gene name |
LOX5 |
Protein name |
Linoleate 9S-lipoxygenase 5 |
Names |
Lipoxygenase 5, AtLOX5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G22400 |
EC number |
1.13.11.58: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9LUW0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LUW0-F1 | Predicted | AlphaFoldDB |
57 variants for Q9LUW0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH02178880 | 22 | T>R | No | 1000Genomes | |
| ENSVATH13968578 | 24 | E>A | No | 1000Genomes | |
| ENSVATH05885467 | 25 | E>D | No | 1000Genomes | |
| ENSVATH05885468 | 26 | D>N | No | 1000Genomes | |
| ENSVATH10858536 | 30 | T>M | No | 1000Genomes | |
| ENSVATH02178881 | 38 | E>K | No | 1000Genomes | |
| ENSVATH00339957 | 61 | N>D | No | 1000Genomes | |
| ENSVATH13968582 | 70 | L>V | No | 1000Genomes | |
| tmp_3_7927224_C_T | 72 | L>F | No | 1000Genomes | |
| tmp_3_7927249_C_T | 80 | P>L | No | 1000Genomes | |
| tmp_3_7927251_G_T | 81 | A>S | No | 1000Genomes | |
| ENSVATH10858551 | 146 | R>P | No | 1000Genomes | |
| tmp_3_7927680_G_A | 151 | G>D | No | 1000Genomes | |
| tmp_3_7927740_G_A | 171 | R>Q | No | 1000Genomes | |
| ENSVATH00339958 | 177 | V>I | No | 1000Genomes | |
| ENSVATH05885501 | 189 | T>I | No | 1000Genomes | |
| ENSVATH05885502 | 234 | G>D | No | 1000Genomes | |
| tmp_3_7928696_C_T | 240 | P>S | No | 1000Genomes | |
| ENSVATH05885504 | 260 | S>P | No | 1000Genomes | |
| tmp_3_7928854_C_A | 264 | D>E | No | 1000Genomes | |
| tmp_3_7928922_G_C | 287 | S>T | No | 1000Genomes | |
| tmp_3_7928987_G_A | 309 | E>K | No | 1000Genomes | |
| tmp_3_7928990_A_T | 310 | I>F | No | 1000Genomes | |
| ENSVATH05885507 | 313 | V>I | No | 1000Genomes | |
| ENSVATH05885515 | 378 | S>N | No | 1000Genomes | |
| ENSVATH13968642 | 392 | M>T | No | 1000Genomes | |
| tmp_3_7929477_A_C | 410 | K>T | No | 1000Genomes | |
|
ENSVATH05885531 ENSVATH05885530 |
412 | C>S | No | 1000Genomes | |
| ENSVATH05885531 | 412 | C>Y | No | 1000Genomes | |
| tmp_3_7929494_G_C | 416 | A>P | No | 1000Genomes | |
| tmp_3_7929527_A_G | 427 | T>A | No | 1000Genomes | |
| tmp_3_7929528_C_A | 427 | T>K | No | 1000Genomes | |
| ENSVATH10858701 | 428 | E>D | No | 1000Genomes | |
| ENSVATH05885534 | 432 | S>* | No | 1000Genomes | |
| ENSVATH05885533 | 432 | S>P | No | 1000Genomes | |
| ENSVATH05885535 | 438 | N>K | No | 1000Genomes | |
| tmp_3_7929561_A_G | 438 | N>S | No | 1000Genomes | |
| ENSVATH00339964 | 456 | A>T | No | 1000Genomes | |
| ENSVATH10858748 | 459 | P>R | No | 1000Genomes | |
| ENSVATH10858749 | 482 | A>E | No | 1000Genomes | |
| tmp_3_7929808_C_A | 485 | T>K | No | 1000Genomes | |
| ENSVATH05885542 | 503 | Y>H | No | 1000Genomes | |
| ENSVATH05885545 | 509 | V>I | No | 1000Genomes | |
| ENSVATH13968667 | 524 | L>H | No | 1000Genomes | |
| ENSVATH10858752 | 529 | A>G | No | 1000Genomes | |
| ENSVATH10858754 | 557 | S>F | No | 1000Genomes | |
| tmp_3_7930407_C_G | 634 | A>G | No | 1000Genomes | |
| ENSVATH13968668 | 662 | S>T | No | 1000Genomes | |
| ENSVATH10858788 | 669 | T>I | No | 1000Genomes | |
| ENSVATH00339971 | 674 | F>I | No | 1000Genomes | |
| ENSVATH02178894 | 677 | N>K | No | 1000Genomes | |
| tmp_3_7930536_A_G | 677 | N>S | No | 1000Genomes | |
| tmp_3_7930548_C_G | 681 | T>S | No | 1000Genomes | |
| tmp_3_7930559_G_A | 685 | D>N | No | 1000Genomes | |
| ENSVATH02178896 | 704 | R>Q | No | 1000Genomes | |
| tmp_3_7930777_T_A | 757 | F>L | No | 1000Genomes | |
| ENSVATH00339977 | 875 | I>L | No | 1000Genomes |
No associated diseases with Q9LUW0
5 regional properties for Q9LUW0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PLAT/LH2 domain | 33 - 181 | IPR001024 |
| domain | Lipoxygenase, C-terminal | 183 - 886 | IPR013819 |
| binding_site | Lipoxygenase, iron binding site | 537 - 551 | IPR020833 |
| conserved_site | Lipoxygenase, conserved site | 564 - 574 | IPR020834 |
| domain | Plant lipoxygenase, PLAT/LH2 domain | 33 - 181 | IPR042057 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.58 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| linoleate 9S-lipoxygenase activity | Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate. |
| metal ion binding | Binding to a metal ion. |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response | Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
| fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. |
| lateral root formation | The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper. |
| lipid oxidation | The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. |
| negative regulation of defense response to insect | Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect. |
| oxylipin biosynthetic process | The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. |
| root development | The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P16050 | ALOX15 | Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (Human) | PR |
| P38419 | CM-LOX1 | Lipoxygenase 7, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| P09186 | LOX1.3 | Seed linoleate 9S-lipoxygenase-3 | Glycine max (Soybean) (Glycine hispida) | PR |
| P38418 | LOX2 | Lipoxygenase 2, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q06327 | LOX1 | Linoleate 9S-lipoxygenase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FNX8 | LOX4 | Lipoxygenase 4, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIHTDIAEIL | CVKPKTTKKT | KTMEEDVKKT | TTMKIEGEVV | VMKKNLLDFK | DVMASLLDRV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NELLGRRVSL | HLISSHQPDP | ANEKRGRLGK | AAHLEKWVTK | IKTSVTAEET | AFGVTFDWDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SMGPPAAFVI | KNHHHSQFYL | KSLTLRGFPD | GEGGATAIHF | ICNSWIYPNH | RYRSDRVFFS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKAYLPSETP | ELIKELREEE | LKNLRGNEKG | GEFKEWDRVY | DYAYYNDLGA | PDKGPDSVRP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLGGSPELPY | PRRGKTGRKS | TKSDPKSESR | LALLNLNIYV | PRDERFSHVK | FSDFLAYALK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVTQVLVPEI | ASVCDKTINE | FDSFEDVFHL | YDGSIKLANG | HTISKLRDVI | PWEMFRELVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NDGERFLKYP | LPDILKESRS | AWRTDEEFAR | EMLAGLNPVV | ISRLQEFPPK | SCLDSAKYGN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QHSSIRTEHI | ESNMNGLNVQ | EALEQNKLYI | LDHHDALMPY | LTRINSTNTK | TYATRTLLLL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QADGTLKPLA | IELSLPHAQG | ESYGSVSKVF | TPAEKGVEGS | VWQLAKAYAA | VNDSGYHQLI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SHWLQTHAVI | EPFIIASNRQ | LSVVHPIHKL | LHPHFRDTMN | INALARHVLI | NSDGVLERTV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FPSRYAMEMS | SSIYKNWVFT | EQALPKDLLK | RGVAVEDPNS | DNGVKLLIED | YPFAVDGLEI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WSAIKTWVTE | YCTFYYNNDK | TVQTDTEIQS | WWTELRTKGH | GDKRHESWWP | SMQTRDDLIE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TCTIIIWIAS | ALHAAVNFGQ | YPYAGFLPNR | PTVSRRFMPE | PGTDEYAELE | EDADVAFLKT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ITPQLQTLLG | ISIIEILSMH | STDEIYLGQR | DSPNWTADDE | PLEAFKRFGK | ELELIENNII |
| 850 | 860 | 870 | 880 | ||
| RRNNDKRFKN | RTGPVNIPYT | LLYPNTTDYT | REGGITGKGI | PNSVSI |