AiPD: Autoinhibited Protein Database

Gene name	LOX1.1 (LOXA)
Protein name	Linoleate 9S-lipoxygenase A
Names	Lipoxygenase A
Species	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway	sly:543994
EC number	1.13.11.58: With incorporation of two atoms of oxygen
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

183-272 (Predicted disordered autoinhibitory region) PR

183-272 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P38415-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
vcZ1M0EKY	10	I>L	No	Ensembl
vcZ1M0EKX	14	H>N	No	Ensembl
vcZ1M0EDK	140	V>I	No	Ensembl
vcZ1M0EAL	181	V>L	No	Ensembl
vcZ1M0EAK	188	T>A	No	Ensembl
vcZ1M0EAG	212	G>S	No	Ensembl
vcZ1M0EAF	213	K>I	No	Ensembl
vcZ1M0EAA	240	R>G	No	Ensembl
vcZ1M0EA9	241	T>K	No	Ensembl
vcZ1M0E96	381	S>T	No	Ensembl
vcZ1M0E8N	408	H>Q	No	Ensembl
vcZ1M0E8M	411	G>D	No	Ensembl
vcZ1M0E8L	412	K>N	No	Ensembl
vcZ1M0E8K	416	L>I	No	Ensembl
vcZ1M0E83	458	F>L	No	Ensembl
vcZ1M0E80	469	A>V	No	Ensembl
vcZ1M0E7Z	482	F>S	No	Ensembl
vcZ1M0E7W	498	G>S	No	Ensembl
vcZ1M0E6L	551	Y>N	No	Ensembl
vcZ1M0E6J	556	D>G	No	Ensembl
vcZ1M0E6I	577	S>T	No	Ensembl
vcZ1M0E6G	592	V>I	No	Ensembl
vcZ1M0E5W	645	S>N	No	Ensembl
vcZ1M0E5T	665	N>D	No	Ensembl
vcZ1M0E5Q	686	P>A	No	Ensembl
vcZ1M0E5P	689	A>P	No	Ensembl
vcZ1M0E5O	693	T>S	No	Ensembl
vcZ1M0E5H	729	R>H	No	Ensembl
vcZ1M0E5F	742	T>S	No	Ensembl
vcZ1M0E58	802	A>T	No	Ensembl
vcZ1M0E55	805	E>V	No	Ensembl
vcZ1M0E54	809	N>K	No	Ensembl
vcZ1M0E52	820	Q>E	No	Ensembl
vcZ1M0E51	826	I>L	No	Ensembl
vcZ1M0E4W	844	T>S	No	Ensembl
vcZ1M0E4U	846	E>G	No	Ensembl

Type	Name	Position	InterPro Accession
domain	PLAT/LH2 domain	17 - 160	IPR001024
domain	Lipoxygenase, C-terminal	162 - 860	IPR013819
binding_site	Lipoxygenase, iron binding site	516 - 530	IPR020833
conserved_site	Lipoxygenase, conserved site	543 - 553	IPR020834
domain	Plant lipoxygenase, PLAT/LH2 domain	17 - 160	IPR042057

		Description
EC Number	1.13.11.58	With incorporation of two atoms of oxygen
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
linoleate 9S-lipoxygenase activity	Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
metal ion binding	Binding to a metal ion.
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.

Name	Definition
fatty acid biosynthetic process	The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
lipid oxidation	The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
oxylipin biosynthetic process	The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P16050	ALOX15	Polyunsaturated fatty acid lipoxygenase ALOX15	Homo sapiens (Human)	PR
P09186	LOX1.3	Seed linoleate 9S-lipoxygenase-3	Glycine max (Soybean) (Glycine hispida)	PR
Q06327	LOX1	Linoleate 9S-lipoxygenase 1	Arabidopsis thaliana (Mouse-ear cress)	PR