Q04752

PR
Gene name
NR5A1 (AD4BP, FTZF1)
Protein name
Steroidogenic factor 1
Names
SF-1, STF-1, Adrenal 4-binding protein, Fushi tarazu factor homolog 1, Nuclear receptor subfamily 5 group A member 1, Steroid hormone receptor Ad4BP
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281948
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-286 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q04752

Entry ID Method Resolution Chain Position Source
AF-Q04752-F1 Predicted AlphaFoldDB

211 variants for Q04752

Variant ID(s) Position Change Description Diseaes Association Provenance
rs435771693 3 Y>F No EVA
rs468763192 18 D>G No EVA
rs447105562 25 Y>D No EVA
rs480100260 33 C>F No EVA
rs457287999 49 C>R No EVA
rs435635451 50 T>P No EVA
rs476348631 83 V>G No EVA
rs454597544 84 R>P No EVA
rs436214543 86 D>A No EVA
rs472394785 88 M>R No EVA
rs465260678 91 G>A No EVA
rs450145366 92 R>G No EVA
rs450145366 92 R>W No EVA
rs437974492 93 N>K No EVA
rs467868098 94 K>N No EVA
rs460540927 95 F>L No EVA
rs449337852 95 F>V No EVA
rs479270262 95 F>Y No EVA
rs478359972 97 P>A No EVA
rs463077809 97 P>H No EVA
rs461026568 98 M>K No EVA
rs476226508 98 M>L No EVA
rs461026568 98 M>R No EVA
rs461026568 98 M>T No EVA
rs453969826 99 Y>* No EVA
rs442466102 99 Y>D No EVA
rs442466102 99 Y>N No EVA
rs472384153 99 Y>S No EVA
rs432135077 100 K>R No EVA
rs471725735 101 R>G No EVA
rs456403881 102 D>A No EVA
rs456403881 102 D>G No EVA
rs438005907 103 R>G No EVA
rs434024094 104 A>G No EVA
rs449303933 104 A>P No EVA
rs449303933 104 A>T No EVA
rs445445022 105 L>R No EVA
rs478196055 106 K>Q No EVA
rs469537508 106 K>R No EVA
rs451152576 107 Q>K No EVA
rs482695119 107 Q>R No EVA
rs460902670 108 Q>K No EVA
rs460215881 110 K>Q No EVA
rs438644410 110 K>R No EVA
rs471562203 111 A>V No EVA
rs474213188 113 I>M No EVA
rs444283480 113 I>T No EVA
rs455769429 114 R>G No EVA
rs433966982 116 N>K No EVA
rs466938364 120 L>R No EVA
rs451670427 122 T>P No EVA
rs469374457 123 G>S No EVA
rs468841658 128 V>G No EVA
rs460254547 145 H>D No EVA
rs444190976 161 L>P No EVA
rs474168794 163 D>A No EVA
rs455537252 167 P>A No EVA
rs440393297 171 M>L No EVA
rs451708118 179 P>R No EVA
rs457579892 183 Y>* No EVA
rs469305391 183 Y>S No EVA
rs435766729 184 L>R No EVA
rs135070013 185 Y>C No EVA
rs135070013 185 Y>S No EVA
rs466525196 193 I>V No EVA
rs444954957 195 S>A No EVA
rs444954957 195 S>T No EVA
rs462617711 198 P>Q No EVA
rs480452426 205 P>S No EVA
rs1116054713 209 P>L No EVA
rs440230046 211 Y>F No EVA
rs458024213 213 Y>* No EVA
rs473216446 213 Y>S No EVA
rs475984680 215 E>K No EVA
rs457346678 216 P>T No EVA
rs475172520 223 V>A No EVA
rs475172520 223 V>G No EVA
rs453636464 227 I>N No EVA
rs453636464 227 I>T No EVA
rs435031511 228 L>P No EVA
rs464860193 229 Q>P No EVA
rs432731555 230 L>P No EVA
rs444892010 230 L>V No EVA
rs469132930 231 L>P No EVA
rs450471143 232 Q>P No EVA
rs480466054 233 L>V No EVA
rs446595668 234 E>A No EVA
rs446595668 234 E>G No EVA
rs459283992 237 E>G No EVA
rs457864442 237 E>Q No EVA
rs876411324 238 D>A No EVA
rs439590225 240 V>G No EVA
rs475776712 241 R>P No EVA
rs442051751 244 I>F No EVA
rs475237716 244 I>T No EVA
rs434968039 245 V>G No EVA
rs453577492 245 V>L No EVA
rs471330870 247 C>G No EVA
rs452808322 249 Q>H No EVA
rs432790440 250 E>A No EVA
rs468917375 250 E>D No EVA
rs457034133 255 R>P No EVA
rs445525729 257 D>N No EVA
rs208359344 260 A>V No EVA
rs446634187 268 M>I No EVA
rs479392171 269 A>P No EVA
rs464314437 272 T>P No EVA
rs445870260 275 S>P No EVA
rs482278903 275 S>Y No EVA
rs463669769 276 I>T No EVA
rs459824361 278 D>A No EVA
rs481617373 278 D>Y No EVA
rs441470831 279 W>G No EVA
rs471161522 279 W>S No EVA
rs443853686 280 A>G No EVA
rs452843161 280 A>P No EVA
rs456917193 283 C>G No EVA
rs456917193 283 C>R No EVA
rs435157290 283 C>S No EVA
rs468134144 285 V>A No EVA
rs452861885 289 L>M No EVA
rs480002055 298 L>M No EVA
rs458213815 299 Q>P No EVA
rs458213815 299 Q>R No EVA
rs464056208 300 N>I No EVA
rs464056208 300 N>S No EVA
rs464056208 300 N>T No EVA
rs475959530 300 N>Y No EVA
rs475289431 301 C>W No EVA
rs455281330 302 W>* No EVA
rs433545664 302 W>C No EVA
rs473101860 303 S>R No EVA
rs451348017 310 H>L No EVA
rs451348017 310 H>R No EVA
rs432957076 312 Y>C No EVA
rs468961730 316 Q>E No EVA
rs450598993 317 H>Q No EVA
rs468295452 330 E>K No EVA
rs471691483 331 V>L No EVA
rs456599327 332 E>D No EVA
rs449457689 335 T>P No EVA
rs435992662 336 V>G No EVA
rs447228535 342 S>P No EVA
rs477134833 342 S>W No EVA
rs449928755 343 L>R No EVA
rs482783867 345 H>L No EVA
rs461263140 347 L>V No EVA
rs478942869 348 V>E No EVA
rs460533926 350 R>L No EVA
rs456439376 353 E>A No EVA
rs471728518 353 E>Q No EVA
rs456439376 353 E>V No EVA
rs444608122 354 L>V No EVA
rs474159413 355 V>G No EVA
rs434318924 356 L>R No EVA
rs455912667 356 L>V No EVA
rs467274824 357 Q>H No EVA
rs431925722 359 H>N No EVA
rs465080946 359 H>P No EVA
rs465080946 359 H>R No EVA
rs449765413 360 A>P No EVA
rs449765413 360 A>S No EVA
rs467592199 362 Q>E No EVA
rs449051674 362 Q>P No EVA
rs449051674 362 Q>R No EVA
rs478986074 363 L>V No EVA
rs438783564 364 D>A No EVA
rs477961333 365 R>G No EVA
rs462897848 365 R>L No EVA
rs462897848 365 R>P No EVA
rs444540552 366 Q>E No EVA
rs455890780 367 E>D No EVA
rs474321384 367 E>G No EVA
rs440572150 368 F>V No EVA
rs431950406 377 F>C No EVA
rs432637683 380 D>G No EVA
rs464168191 381 V>G No EVA
rs445611620 382 K>N No EVA
rs481993475 383 F>L No EVA
rs481993475 383 F>V No EVA
rs469873245 384 L>P No EVA
rs481173635 386 N>K No EVA
rs459533405 387 H>R No EVA
rs441189857 388 S>I No EVA
rs477280373 388 S>R No EVA
rs441189857 388 S>T No EVA
rs458914424 389 L>M No EVA
rs443578859 389 L>Q No EVA
rs454972442 390 V>A No EVA
rs454972442 390 V>G No EVA
rs476753641 390 V>M No EVA
rs442984850 391 K>N No EVA
rs472645600 392 E>* No EVA
rs472093887 394 Q>H No EVA
rs432681696 394 Q>P No EVA
rs452035576 398 N>I No EVA
rs469876194 411 H>P No EVA
rs461619504 422 C>Y No EVA
rs436073132 424 V>G No EVA
rs465994663 425 E>* No EVA
rs447465448 434 K>N No EVA
rs458821477 435 E>A No EVA
rs450006022 435 E>D No EVA
rs477361219 435 E>K No EVA
rs876362060 438 Y>S No EVA
rs483023354 439 H>N No EVA
rs461168914 446 M>I No EVA
rs442923385 448 R>L No EVA
rs441474744 456 L>R No EVA
rs472481758 457 Q>E No EVA
rs460597860 460 Q>E No EVA

No associated diseases with Q04752

2 regional properties for Q04752

Type Name Position InterPro Accession
domain Nuclear hormone receptor, ligand-binding domain 222 - 459 IPR000536
domain Zinc finger, nuclear hormone receptor-type 10 - 85 IPR001628

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.

10 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
enzyme binding Binding to an enzyme, a protein with catalytic activity.
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
nuclear steroid receptor activity Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
transcription corepressor binding Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
zinc ion binding Binding to a zinc ion (Zn).

18 GO annotations of biological process

Name Definition
adrenal gland development The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.
female gonad development The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
hormone-mediated signaling pathway The series of molecular signals mediated by the detection of a hormone.
Leydig cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.
luteinization The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.
maintenance of protein location in nucleus Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
male sex determination The specification of male sex of an individual organism.
multicellular organism aging An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
negative regulation of female gonad development Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of male gonad development Any process that activates or increases the frequency, rate or extent of male gonad development.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
Sertoli cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
sex determination Any process that establishes and transmits the specification of sexual status of an individual organism.
tissue development The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O42101 NR5A2 Nuclear receptor subfamily 5 group A member 2 Gallus gallus (Chicken) PR
Q9GKL2 NR5A1 Steroidogenic factor 1 Equus caballus (Horse) PR
O00482 NR5A2 Nuclear receptor subfamily 5 group A member 2 Homo sapiens (Human) PR
Q13285 NR5A1 Steroidogenic factor 1 Homo sapiens (Human) PR
P45448 Nr5a2 Nuclear receptor subfamily 5 group A member 2 Mus musculus (Mouse) PR
P33242 Nr5a1 Steroidogenic factor 1 Mus musculus (Mouse) PR
P79387 NR5A1 Steroidogenic factor 1 Sus scrofa (Pig) PR
Q9QWM1 Nr5a2 Nuclear receptor subfamily 5 group A member 2 Rattus norvegicus (Rat) PR
P50569 Nr5a1 Steroidogenic factor 1 Rattus norvegicus (Rat) PR
Q19345 nhr-25 Nuclear hormone receptor family member nhr-25 Caenorhabditis elegans PR
10 20 30 40 50 60
MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT ESQSCKIDKT
70 80 90 100 110 120
QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK RDRALKQQKK AQIRANGFKL
130 140 150 160 170 180
ETGPPVGVPP PPPPPPDYML PHGLHASEPK GLASGPPAGP LGDFGAPALP MAVPSAHGPL
190 200 210 220 230 240
AGYLYPAFPG RAIKSEYPEP YASPPQPGPP YGYPEPFSGG PGVPELILQL LQLEPDEDQV
250 260 270 280 290 300
RARIVGCLQE PAKGRPDQPA PFSLLCRMAD QTFISIVDWA RRCMVFKELE VADQMTLLQN
310 320 330 340 350 360
CWSELLVFDH IYRQIQHGKE GSILLVTGQE VELTTVAAQA GSLLHSLVLR AQELVLQLHA
370 380 390 400 410 420
LQLDRQEFVC LKFLILFSLD VKFLNNHSLV KEAQEKANAA LLDYTLCHYP HCGDKFQQLL
430 440 450 460
LCLVEVRALS MQAKEYLYHK HLGNEMPRNN LLIEMLQAKQ T