O42101

PR
Gene name
NR5A2
Protein name
Nuclear receptor subfamily 5 group A member 2
Names
FTF/LRH-1, OR2.0
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395961
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O42101

Entry ID Method Resolution Chain Position Source
AF-O42101-F1 Predicted AlphaFoldDB

No variants for O42101

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O42101

No associated diseases with O42101

2 regional properties for O42101

Type Name Position InterPro Accession
domain Nuclear hormone receptor, ligand-binding domain 260 - 499 IPR000536
domain Zinc finger, nuclear hormone receptor-type 43 - 118 IPR001628

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
RNA polymerase II transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.

3 GO annotations of molecular function

Name Definition
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
hormone-mediated signaling pathway The series of molecular signals mediated by the detection of a hormone.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
tissue development The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04752 NR5A1 Steroidogenic factor 1 Bos taurus (Bovine) PR
Q13285 NR5A1 Steroidogenic factor 1 Homo sapiens (Human) PR
O00482 NR5A2 Nuclear receptor subfamily 5 group A member 2 Homo sapiens (Human) PR
P33242 Nr5a1 Steroidogenic factor 1 Mus musculus (Mouse) PR
P45448 Nr5a2 Nuclear receptor subfamily 5 group A member 2 Mus musculus (Mouse) PR
P79387 NR5A1 Steroidogenic factor 1 Sus scrofa (Pig) PR
P50569 Nr5a1 Steroidogenic factor 1 Rattus norvegicus (Rat) PR
Q9QWM1 Nr5a2 Nuclear receptor subfamily 5 group A member 2 Rattus norvegicus (Rat) PR
Q19345 nhr-25 Nuclear hormone receptor family member nhr-25 Caenorhabditis elegans PR
10 20 30 40 50 60
MLPKVETEAL GLARSNGEQG QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL
70 80 90 100 110 120
LTCESCKGFF KRTVQNNKRY TCIENQNCQI DKTQRKRCPY CRFQKCLSVG MKLEAVRADR
130 140 150 160 170 180
MRGGRNKFGP MYKRDRALKQ QKKALIRANG LKLEAMTQVI QAMPTDLTIS SAIQNIHSAS
190 200 210 220 230 240
KGLPLNHTAL PPTDYDRSPF VTSPISMTMP PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS
250 260 270 280 290 300
PESIMGYSYM DGYQTSSPAS IPHLILELQK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLN
310 320 330 340 350 360
TFGLMCKMAD QTLFSIVEWA RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHVKE
370 380 390 400 410 420
GSILLVTGQQ VDYSVIASQA GATLNNLMSH AQELVAKLRS LQFDLREFVC LKFLVLFSLD
430 440 450 460 470 480
VKNLENFQLV EGVQEQVNAA LLDYTMCNYP QQTDKFGQLL LRLPEIRAIS MQAEEYLYCK
490 500
HLNGDVPCNN LLIEMLHAKR A