P45448
PR
Gene name |
Nr5a2 (Lrh1) |
Protein name |
Nuclear receptor subfamily 5 group A member 2 |
Names |
Liver receptor homolog 1, LRH-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:26424 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P45448
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1PK5 | X-ray | 240 A | A/B | 313-560 | PDB |
| 1ZH7 | X-ray | 250 A | A/B | 318-560 | PDB |
| 3F5C | X-ray | 300 A | A | 313-560 | PDB |
| AF-P45448-F1 | Predicted | AlphaFoldDB |
24 variants for P45448
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3390537696 | 4 | S>* | No | EVA | |
| rs3388505880 | 12 | E>D | No | EVA | |
| rs16785560 | 35 | R>L | No | EVA | |
| rs3388505078 | 42 | K>N | No | EVA | |
| rs3388502367 | 74 | V>I | No | EVA | |
| rs3388499108 | 88 | Q>H | No | EVA | |
| rs3388503388 | 166 | K>I | No | EVA | |
| rs3412787095 | 167 | C>S | No | EVA | |
| rs3388499131 | 210 | N>D | No | EVA | |
| rs3388499374 | 224 | M>K | No | EVA | |
| rs1133021745 | 279 | P>A | No | EVA | |
| rs1132219744 | 281 | G>D | No | EVA | |
| rs3388503961 | 313 | Q>H | No | EVA | |
| rs215514481 | 319 | S>T | No | EVA | |
| rs3388504766 | 481 | K>E | No | EVA | |
| rs3388502289 | 481 | K>SDG* | No | EVA | |
| rs3388503360 | 482 | N>D | No | EVA | |
| rs3388504680 | 482 | N>I | No | EVA | |
| rs3410818988 | 483 | L>M | No | EVA | |
| rs3388505953 | 484 | E>G | No | EVA | |
| rs3388504140 | 524 | E>* | No | EVA | |
| rs3388503527 | 537 | Y>F | No | EVA | |
| rs3388505140 | 544 | D>N | No | EVA | |
| rs3388505899 | 557 | A>T | No | EVA |
No associated diseases with P45448
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA polymerase II transcription regulator complex | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. |
13 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| double-stranded DNA binding | Binding to double-stranded DNA. |
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| transcription coregulator binding | Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. |
| zinc ion binding | Binding to a zinc ion (Zn). |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| acinar cell differentiation | The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. |
| bile acid metabolic process | The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. |
| calcineurin-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. |
| cellular response to leukemia inhibitory factor | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. |
| cholesterol homeostasis | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. |
| hormone-mediated signaling pathway | The series of molecular signals mediated by the detection of a hormone. |
| pancreas morphogenesis | Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| positive regulation of viral genome replication | Any process that activates or increases the frequency, rate or extent of viral genome replication. |
| regulation of cell population proliferation | Any process that modulates the frequency, rate or extent of cell proliferation. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| tissue development | The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04752 | NR5A1 | Steroidogenic factor 1 | Bos taurus (Bovine) | PR |
| O42101 | NR5A2 | Nuclear receptor subfamily 5 group A member 2 | Gallus gallus (Chicken) | PR |
| Q13285 | NR5A1 | Steroidogenic factor 1 | Homo sapiens (Human) | PR |
| O00482 | NR5A2 | Nuclear receptor subfamily 5 group A member 2 | Homo sapiens (Human) | PR |
| P33242 | Nr5a1 | Steroidogenic factor 1 | Mus musculus (Mouse) | PR |
| P79387 | NR5A1 | Steroidogenic factor 1 | Sus scrofa (Pig) | PR |
| P50569 | Nr5a1 | Steroidogenic factor 1 | Rattus norvegicus (Rat) | PR |
| Q9QWM1 | Nr5a2 | Nuclear receptor subfamily 5 group A member 2 | Rattus norvegicus (Rat) | PR |
| Q19345 | nhr-25 | Nuclear hormone receptor family member nhr-25 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASLDTGDF | QEFLKHGLTA | IASAPGSETR | HSPKREEQLR | EKRAGLPDRH | RRPIPARSRL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VMLPKVETEA | PGLVRSHGEQ | GQMPENMQVS | QFKMVNYSYD | EDLEELCPVC | GDKVSGYHYG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLTCESCKGF | FKRTVQNQKR | YTCIENQNCQ | IDKTQRKRCP | YCRFKKCIDV | GMKLEAVRAD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RMRGGRNKFG | PMYKRDRALK | QQKKALIRAN | GLKLEAMSQV | IQAMPSDLTS | AIQNIHSASK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GLPLSHVALP | PTDYDRSPFV | TSPISMTMPP | HSSLHGYQPY | GHFPSRAIKS | EYPDPYSSSP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESMMGYSYMD | GYQTNSPASI | PHLILELLKC | EPDEPQVQAK | IMAYLQQEQS | NRNRQEKLSA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FGLLCKMADQ | TLFSIVEWAR | SSIFFRELKV | DDQMKLLQNC | WSELLILDHI | YRQVAHGKEG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TIFLVTGEHV | DYSTIISHTE | VAFNNLLSLA | QELVVRLRSL | QFDQREFVCL | KFLVLFSSDV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KNLENLQLVE | GVQEQVNAAL | LDYTVCNYPQ | QTEKFGQLLL | RLPEIRAISK | QAEDYLYYKH |
| 550 | |||||
| VNGDVPYNNL | LIEMLHAKRA |