Q9GKL2
Gene name |
NR5A1 (SF1) |
Protein name |
Steroidogenic factor 1 |
Names |
SF-1, STF-1, Nuclear receptor subfamily 5 group A member 1 |
Species |
Equus caballus (Horse) |
KEGG Pathway |
ecb:100033902 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9GKL2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9GKL2-F1 | Predicted | AlphaFoldDB |
No variants for Q9GKL2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9GKL2 | |||||
No associated diseases with Q9GKL2
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| female gonad development | The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. |
| male gonad development | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| sex determination | Any process that establishes and transmits the specification of sexual status of an individual organism. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04752 | NR5A1 | Steroidogenic factor 1 | Bos taurus (Bovine) | PR |
| Q13285 | NR5A1 | Steroidogenic factor 1 | Homo sapiens (Human) | PR |
| P33242 | Nr5a1 | Steroidogenic factor 1 | Mus musculus (Mouse) | PR |
| P79387 | NR5A1 | Steroidogenic factor 1 | Sus scrofa (Pig) | PR |
| P50569 | Nr5a1 | Steroidogenic factor 1 | Rattus norvegicus (Rat) | PR |
| Q19345 | nhr-25 | Nuclear hormone receptor family member nhr-25 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDYSYDEDLD | ELCPVCGDKV | SGYHYGLLTC | ESCKGFFKRT | VQNNKHYTCT | ESQSCKIDKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRKRCPFCRF | QKCLTVGMRL | EAVRADRMRG | GRNKFGPMYK | RDRALKQQKK | AQIRANGFKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETGPPMGVPP | PPPPPPDYML | PPGLHVPEPK | GLASGPPAGP | LGDFGAPALP | MAVPSTNGPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AGYLYPAFPG | RAIKSEYPEP | YASPPQPGPP | YGYPEPFSGG | PGVPELILQL | LQLEPDEDQV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RARIIGCLQE | PAKGRPDQPA | SFNLLCRMAD | QTFISIVDWA | RRCMVFKELE | VADQMTLLQN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CWSELLVFDH | IYRQVQHGKE | GSTLLVTGQE | VELTTVAAQA | GSLLHGLVLR | AQELVLQMHA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LQLDRQEFVC | LKFLILFSLD | VKFLNNHSLV | KDAQEKANTA | LLDYTLCHYP | HCGDKFQQLL |
| 430 | 440 | 450 | 460 | ||
| LCLVEVRALS | MQAKEYLYHK | HLGNEMPRNN | LLIEMLQAKQ | T |