P97784
PR
Gene name |
Cry1 |
Protein name |
Cryptochrome-1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12952 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
15 structures for P97784
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4CT0 | X-ray | 245 A | A | 1-496 | PDB |
| 4K0R | X-ray | 265 A | A | 1-606 | PDB |
| 5T5X | X-ray | 184 A | A | 1-491 | PDB |
| 6KX4 | X-ray | 200 A | A | 1-496 | PDB |
| 6KX5 | X-ray | 200 A | A | 1-496 | PDB |
| 6KX6 | X-ray | 200 A | A/B | 1-496 | PDB |
| 6KX7 | X-ray | 210 A | A | 1-496 | PDB |
| 6LUE | X-ray | 210 A | A/B | 1-496 | PDB |
| 6OF7 | X-ray | 311 A | A | 1-491 | PDB |
| 7D0M | X-ray | 195 A | A | 1-496 | PDB |
| 7D19 | X-ray | 235 A | A/B | 1-496 | PDB |
| 7D1C | X-ray | 191 A | A | 1-496 | PDB |
| 7DLI | X-ray | 220 A | A/B/C | 1-496 | PDB |
| 7WVA | X-ray | 205 A | A | 1-496 | PDB |
| AF-P97784-F1 | Predicted | AlphaFoldDB |
27 variants for P97784
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs261256147 | 92 | N>S | No | EVA | |
| rs3389119056 | 131 | T>I | No | EVA | |
| rs3401663204 | 132 | L>V | No | EVA | |
| rs3401462643 | 175 | I>M | No | EVA | |
| rs3401390789 | 254 | Y>C | No | EVA | |
| rs3401302063 | 255 | L>H | No | EVA | |
| rs3400792784 | 256 | R>S | No | EVA | |
| rs3389119898 | 260 | L>S | No | EVA | |
| rs3401550993 | 269 | L>I | No | EVA | |
| rs3389119081 | 306 | F>S | No | EVA | |
| rs3389119287 | 336 | G>S | No | EVA | |
| rs3389119903 | 337 | F>S | No | EVA | |
| rs3389129699 | 354 | H>Y | No | EVA | |
| rs3389060335 | 369 | D>E | No | EVA | |
| rs3389119878 | 372 | I>M | No | EVA | |
| rs3389112460 | 372 | I>S | No | EVA | |
| rs3389092727 | 373 | S>G | No | EVA | |
| rs3389112458 | 399 | W>* | No | EVA | |
| rs3389097009 | 403 | S>R | No | EVA | |
| rs3389128747 | 420 | R>M | No | EVA | |
| rs3389121983 | 424 | P>S | No | EVA | |
| rs3389115214 | 428 | Y>N | No | EVA | |
| rs30137262 | 527 | S>G | No | EVA | |
| rs3413135566 | 557 | L>S | No | EVA | |
| rs216435432 | 557 | L>V | No | EVA | |
| rs251670575 | 560 | A>T | No | EVA | |
| rs3389060348 | 600 | V>F | No | EVA |
No associated diseases with P97784
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
11 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| double-stranded DNA binding | Binding to double-stranded DNA. |
| E-box binding | Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
| FAD binding | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. |
| histone deacetylase binding | Binding to histone deacetylase. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| nuclear receptor binding | Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. |
| phosphatase binding | Binding to a phosphatase. |
| photoreceptor activity | The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
22 GO annotations of biological process
| Name | Definition |
|---|---|
| circadian regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| DNA damage induced protein phosphorylation | The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage. |
| entrainment of circadian clock by photoperiod | The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). |
| gluconeogenesis | The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. |
| glucose homeostasis | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. |
| lipid storage | The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
| negative regulation of circadian rhythm | Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of G protein-coupled receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway. |
| negative regulation of glucocorticoid receptor signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway. |
| negative regulation of glucocorticoid secretion | Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion. |
| negative regulation of gluconeogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. |
| negative regulation of protein ubiquitination | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of protein ubiquitination | Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| regulation of circadian rhythm | Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. |
| regulation of DNA damage checkpoint | Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. |
| response to activity | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. |
| response to glucagon | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. |
| response to insulin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| response to light stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8QG60 | CRY2 | Cryptochrome-2 | Gallus gallus (Chicken) | PR |
| Q49AN0 | CRY2 | Cryptochrome-2 | Homo sapiens (Human) | PR |
| Q16526 | CRY1 | Cryptochrome-1 | Homo sapiens (Human) | PR |
| Q9R194 | Cry2 | Cryptochrome-2 | Mus musculus (Mouse) | PR |
| Q923I8 | Cry2 | Cryptochrome-2 | Rattus norvegicus (Rat) | PR |
| Q0E2Y1 | UVR3 | (6-4)DNA photolyase | Oryza sativa subsp japonica (Rice) | PR |
| Q96524 | CRY2 | Cryptochrome-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48652 | UVR3 | (6-4)DNA photolyase | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGVNAVHWFR | KGLRLHDNPA | LKECIQGADT | IRCVYILDPW | FAGSSNVGIN | RWRFLLQCLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DLDANLRKLN | SRLFVIRGQP | ADVFPRLFKE | WNITKLSIEY | DSEPFGKERD | AAIKKLATEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVEVIVRISH | TLYDLDKIIE | LNGGQPPLTY | KRFQTLVSKM | EPLEMPADTI | TSDVIGKCMT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLSDDHDEKY | GVPSLEELGF | DTDGLSSAVW | PGGETEALTR | LERHLERKAW | VANFERPRMN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ANSLLASPTG | LSPYLRFGCL | SCRLFYFKLT | DLYKKVKKNS | SPPLSLYGQL | LWREFFYTAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TNNPRFDKME | GNPICVQIPW | DKNPEALAKW | AEGRTGFPWI | DAIMTQLRQE | GWIHHLARHA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VACFLTRGDL | WISWEEGMKV | FEELLLDADW | SINAGSWMWL | SCSSFFQQFF | HCYCPVGFGR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RTDPNGDYIR | RYLPVLRGFP | AKYIYDPWNA | PEGIQKVAKC | LIGVNYPKPM | VNHAEASRLN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IERMKQIYQQ | LSRYRGLGLL | ASVPSNSNGN | GGLMGYAPGE | NVPSCSSSGN | GGLMGYAPGE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NVPSCSGGNC | SQGSGILHYA | HGDSQQTHSL | KQGRSSAGTG | LSSGKRPSQE | EDAQSVGPKV |
| QRQSSN |