AiPD: Autoinhibited Protein Database

Gene name	UVR3 (At3g15620, SJ11.2)
Protein name	(6-4)DNA photolyase
Names	Protein UV repair defective 3
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G15620
EC number	4.1.99.13: Other carbon-carbon lyases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

495-556 (Predicted disordered autoinhibitory region) PR

495-556 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3FY4	X-ray	270 A	A/B/C	20-556	PDB
AF-O48652-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH10700245	12	Y>H	No	1000Genomes
tmp_3_5296494_A_G	19	S>P	No	1000Genomes
ENSVATH13925413	55	V>I	No	1000Genomes
tmp_3_5296372_G_C	59	D>E	No	1000Genomes
tmp_3_5296343_G_A	69	A>V	No	1000Genomes
ENSVATH10700214	141	V>I	No	1000Genomes
tmp_3_5295863_T_C	159	S>G	No	1000Genomes
ENSVATH10700211	161	T>S	No	1000Genomes
ENSVATH10700210	163	F>I	No	1000Genomes
tmp_3_5295838_T_A	167	H>L	No	1000Genomes
ENSVATH05838280	176	P>L	No	1000Genomes
ENSVATH05838278	186	V>I	No	1000Genomes
tmp_3_5295680_C_A	189	E>D	No	1000Genomes
tmp_3_5295678_G_T	190	P>H	No	1000Genomes
tmp_3_5295670_C_T	193	A>T	No	1000Genomes
ENSVATH00325054	197	L>F	No	1000Genomes
ENSVATH05838277	207	I>V	No	1000Genomes
tmp_3_5295625_C_T	208	G>R	No	1000Genomes
tmp_3_5295624_C_A	208	G>V	No	1000Genomes
ENSVATH10700209	229	D>G	No	1000Genomes
ENSVATH10700207	237	F>L	No	1000Genomes
tmp_3_5295118_G_A	277	T>I	No	1000Genomes
tmp_3_5294991_C_T	291	R>K	No	1000Genomes
ENSVATH05838267	303	D>G	No	1000Genomes
ENSVATH00325053	309	S>L	No	1000Genomes
ENSVATH05838264	326	T>S	No	1000Genomes
tmp_3_5294808_T_C	327	T>A	No	1000Genomes
ENSVATH10700193	341	R>Q	No	1000Genomes
ENSVATH10700189	360	D>V	No	1000Genomes
tmp_3_5294344_A_G	399	F>L	No	1000Genomes
tmp_3_5294278_T_A	421	N>Y	No	1000Genomes
tmp_3_5294040_C_G	455	K>N	No	1000Genomes
ENSVATH10700188	466	D>Y	No	1000Genomes
ENSVATH10700187	467	M>I	No	1000Genomes
ENSVATH10700186	474	E>K	No	1000Genomes
tmp_3_5293882_C_G	481	S>T	No	1000Genomes
tmp_3_5293585_T_C	521	K>E	No	1000Genomes
ENSVATH00325047	539	Q>E	No	1000Genomes

Type	Name	Position	InterPro Accession
conserved_site	Cytochrome P450, conserved site	438 - 447	IPR017972

		Description
EC Number	4.1.99.13	Other carbon-carbon lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
deoxyribodipyrimidine photo-lyase activity	Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.
DNA (6-4) photolyase activity	Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
FAD binding	Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

Name	Definition
circadian regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
entrainment of circadian clock by photoperiod	The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
pyrimidine dimer repair	The repair of UV-induced T-T, C-T and C-C dimers.
response to UV	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8QG60	CRY2	Cryptochrome-2	Gallus gallus (Chicken)	PR
Q16526	CRY1	Cryptochrome-1	Homo sapiens (Human)	PR
Q49AN0	CRY2	Cryptochrome-2	Homo sapiens (Human)	PR
P97784	Cry1	Cryptochrome-1	Mus musculus (Mouse)	PR
Q9R194	Cry2	Cryptochrome-2	Mus musculus (Mouse)	PR
Q923I8	Cry2	Cryptochrome-2	Rattus norvegicus (Rat)	PR
Q0E2Y1	UVR3	(6-4)DNA photolyase	Oryza sativa subsp japonica (Rice)	PR
Q96524	CRY2	Cryptochrome-2	Arabidopsis thaliana (Mouse-ear cress)	PR