AiPD: Autoinhibited Protein Database

P62841

Gene name	RPS15 (RIG)
Protein name	40S ribosomal protein S15
Names	RIG protein, Small ribosomal subunit protein uS19
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6209
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

19-91 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

19-91 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

90 structures for P62841

Entry ID	Method	Resolution	Chain	Position	Source
4UG0	EM	-	SP	1-145	PDB
4V6X	EM	500 A	AP	1-145	PDB
5A2Q	EM	390 A	P	1-145	PDB
5AJ0	EM	350 A	BP	1-145	PDB
5FLX	EM	390 A	P	1-145	PDB
5LKS	EM	360 A	SP	1-145	PDB
5OA3	EM	430 A	P	1-145	PDB
5T2C	EM	360 A	Ax	1-145	PDB
5VYC	X-ray	600 A	P1/P2/P3/P4/P5/P6	1-145	PDB
6FEC	EM	630 A	n	4-130	PDB
6G18	EM	360 A	P	1-145	PDB
6G4S	EM	400 A	P	1-145	PDB
6G4W	EM	450 A	P	1-145	PDB
6G51	EM	410 A	P	1-145	PDB
6G53	EM	450 A	P	1-145	PDB
6G5H	EM	360 A	P	1-145	PDB
6G5I	EM	350 A	P	1-145	PDB
6IP5	EM	390 A	2w	1-145	PDB
6IP6	EM	450 A	2w	1-145	PDB
6IP8	EM	390 A	2w	1-145	PDB
6OLE	EM	310 A	SP	10-136	PDB
6OLF	EM	390 A	SP	10-136	PDB
6OLG	EM	340 A	BP	12-131	PDB
6OLI	EM	350 A	SP	10-136	PDB
6OLZ	EM	390 A	BP	12-131	PDB
6OM0	EM	310 A	SP	10-136	PDB
6OM7	EM	370 A	SP	10-136	PDB
6QZP	EM	290 A	SP	10-136	PDB
6XA1	EM	280 A	SP	13-143	PDB
6Y0G	EM	320 A	SP	1-145	PDB
6Y2L	EM	300 A	SP	1-145	PDB
6Y57	EM	350 A	SP	1-145	PDB
6YBS	EM	310 A	b	1-145	PDB
6Z6L	EM	300 A	SP	1-145	PDB
6Z6M	EM	310 A	SP	1-145	PDB
6Z6N	EM	290 A	SP	1-145	PDB
6ZLW	EM	260 A	Q	1-145	PDB
6ZM7	EM	270 A	SP	1-145	PDB
6ZME	EM	300 A	SP	1-145	PDB
6ZMI	EM	260 A	SP	1-145	PDB
6ZMO	EM	310 A	SP	1-145	PDB
6ZMT	EM	300 A	Q	1-145	PDB
6ZMW	EM	370 A	b	1-145	PDB
6ZN5	EM	320 A	Q	15-134	PDB
6ZOJ	EM	280 A	P	1-145	PDB
6ZOL	EM	280 A	P	1-145	PDB
6ZON	EM	300 A	o	1-145	PDB
6ZP4	EM	290 A	o	1-145	PDB
6ZUO	EM	310 A	P	1-145	PDB
6ZV6	EM	290 A	P	1-145	PDB
6ZVH	EM	290 A	P	10-138	PDB
6ZVJ	EM	380 A	o	15-133	PDB
6ZXD	EM	320 A	P	1-145	PDB
6ZXE	EM	300 A	P	1-145	PDB
6ZXF	EM	370 A	P	1-145	PDB
6ZXG	EM	260 A	P	1-145	PDB
6ZXH	EM	270 A	P	1-145	PDB
7A09	EM	350 A	o	1-145	PDB
7K5I	EM	290 A	P	1-145	PDB
7QP6	EM	470 A	b	1-145	PDB
7QP7	EM	370 A	b	1-145	PDB
7R4X	EM	215 A	P	1-145	PDB
7TQL	EM	340 A	Q	15-129	PDB
7WTT	EM	310 A	P	1-145	PDB
7WTU	EM	300 A	P	1-145	PDB
7WTV	EM	350 A	P	1-145	PDB
7WTW	EM	320 A	P	1-145	PDB
7WTX	EM	310 A	P	1-145	PDB
7WTZ	EM	300 A	P	1-145	PDB
7WU0	EM	330 A	P	1-145	PDB
7XNX	EM	270 A	SP	1-145	PDB
7XNY	EM	250 A	SP	1-145	PDB
8G5Y	EM	229 A	SP	1-145	PDB
8G60	EM	254 A	SP	1-145	PDB
8G61	EM	294 A	SP	1-145	PDB
8G6J	EM	280 A	SP	1-145	PDB
8GLP	EM	167 A	SP	1-145	PDB
8IFD	EM	259 A	2w	1-145	PDB
8IFE	EM	257 A	2w	1-145	PDB
8JDJ	EM	250 A	AB	1-145	PDB
8JDK	EM	226 A	AB	1-145	PDB
8JDL	EM	242 A	AB	1-145	PDB
8JDM	EM	267 A	AB	1-145	PDB
8OZ0	EM	350 A	j	1-145	PDB
8PPK	EM	298 A	P	1-145	PDB
8PPL	EM	265 A	AP	1-145	PDB
8T4S	EM	260 A	P	1-145	PDB
8Y0W	EM	340 A	SP	1-145	PDB
8Y0X	EM	330 A	SP	1-145	PDB
AF-P62841-F1	Predicted				AlphaFoldDB

108 variants for P62841

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA402998985 rs1477278675	2	A>V		No	ClinGen TOPMed
rs532256746 CA9044425	4	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs532256746 CA402999020	4	V>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1335113893 CA402999013	4	V>I		No	ClinGen gnomAD
CA402999022 rs1222454479	5	E>K		No	ClinGen gnomAD
TCGA novel	5	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753116376 CA9044427	6	Q>H		No	ClinGen ExAC gnomAD
CA402999125 rs1278437094	8	K>R		No	ClinGen gnomAD
rs764754977 CA9044429	9	K>Q		No	ClinGen ExAC gnomAD
CA9044431 rs757963954	11	T>A		No	ClinGen ExAC gnomAD
CA9044432 rs779549419	11	T>I		No	ClinGen ExAC gnomAD
rs1172700836 CA402999215	13	R>C		No	ClinGen gnomAD
CA402999320 rs1250491926	16	T>I		No	ClinGen gnomAD
TCGA novel	19	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402999418 rs1305505221	21	D>N		No	ClinGen gnomAD
CA9044442 rs746037588	28	M>V		No	ClinGen ExAC gnomAD
CA402999618 rs1266858224	29	S>A		No	ClinGen TOPMed gnomAD
rs1254170721 CA402999627	29	S>F		No	ClinGen gnomAD
rs1266858224 CA402999610	29	S>T		No	ClinGen TOPMed gnomAD
TCGA novel	31	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1288003794 CA403001100	32	Q>*		No	ClinGen gnomAD
CA403001103 rs1416805706	32	Q>H		No	ClinGen gnomAD
rs980644616 CA304045089	32	Q>L		No	ClinGen TOPMed gnomAD
CA403001101 rs980644616	32	Q>P		No	ClinGen TOPMed gnomAD
CA403001136 rs1294021256	35	Q>E		No	ClinGen gnomAD
CA403001141 rs1384164310	35	Q>R		No	ClinGen TOPMed
CA403001152 rs1312063572	36	L>V		No	ClinGen TOPMed
CA403001167 rs1227151664	37	Y>C		No	ClinGen gnomAD
CA403001161 rs1435186527	37	Y>N		No	ClinGen TOPMed
CA403001177 rs1286935142	38	S>C		No	ClinGen TOPMed gnomAD
rs1286935142 CA403001176	38	S>G		No	ClinGen TOPMed gnomAD
CA403001180 rs1317965614	38	S>T		No	ClinGen gnomAD
rs1215522829 CA403001191	39	A>V		No	ClinGen gnomAD
CA403001203 rs1487115616	40	R>H		No	ClinGen gnomAD
CA403001220 rs1189575211	41	Q>H		No	ClinGen gnomAD
CA9044454 rs752461630	41	Q>L		No	ClinGen ExAC
CA403001213 rs752461630	41	Q>P		No	ClinGen ExAC
rs1257650791 CA403001225	42	R>Q		No	ClinGen gnomAD
rs749210788 CA403001278	47	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9044458 RCV000506757 rs201657403 RCV001662513	47	R>P		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs201657403 CA304045124	47	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs749210788 CA9044457	47	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1445902691 CA403001321	51	R>Q		No	ClinGen TOPMed gnomAD
rs1354960219 CA403001320	51	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	52	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1281286559 CA403001335	53	Q>P		No	ClinGen gnomAD
CA403001352 rs1374705109	54	H>L		No	ClinGen gnomAD
CA304045149 rs778995103	54	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA9044460 rs746003968	55	S>F		No	ClinGen ExAC
TCGA novel	57	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747355862 CA403001401	59	R>C		No	ClinGen ExAC TOPMed gnomAD
rs747355862 CA9044463	59	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA403001406 rs1207432057	59	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9044465 rs776888428	61	R>C		No	ClinGen ExAC TOPMed
rs1390781352 CA403001429	61	R>H		No	ClinGen TOPMed
CA403001442 rs1176524179	62	K>M		No	ClinGen TOPMed gnomAD
rs1176524179 CA403001441	62	K>R		No	ClinGen TOPMed gnomAD
rs1378310231 CA403001448	63	A>T		No	ClinGen gnomAD
rs1455408212 CA403001456	63	A>V		No	ClinGen gnomAD
TCGA novel	64	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1040563405 CA304045242	65	K>T		No	ClinGen TOPMed
rs1273622289 CA403001498	66	E>G		No	ClinGen Ensembl
rs1331000682 CA403001506	67	A>T		No	ClinGen gnomAD
rs1355146615 CA403001512	67	A>V		No	ClinGen gnomAD
rs1329880272 CA403001518	68	P>A		No	ClinGen gnomAD
CA9044472 rs755797892	69	P>S		No	ClinGen ExAC gnomAD
CA304045279 rs116840813	70	M>V		No	ClinGen gnomAD
rs1180219795 CA403001568	72	K>Q		No	ClinGen TOPMed
CA403001574 rs1437770939	72	K>R		No	ClinGen TOPMed
rs1251249559 CA403001592	73	P>L		No	ClinGen TOPMed
rs146047499 CA9044473	73	P>S		No	ClinGen ExAC gnomAD
CA403001608 rs1467300522	74	E>D		No	ClinGen TOPMed
CA403001652 rs1437887093	78	T>M		No	ClinGen gnomAD
CA9044475 CA403001667 rs534496568	79	H>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1011629191 CA403001689	82	D>H		No	ClinGen gnomAD
rs1011629191 CA304045302	82	D>N		No	ClinGen gnomAD
rs780303538 CA9044479	83	M>V		No	ClinGen ExAC gnomAD
rs1336626289 CA403001740	85	I>T		No	ClinGen TOPMed
CA403001765 rs1420377163	87	P>L		No	ClinGen gnomAD
rs770327699 CA9044484	89	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1336285256	92	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403001830 rs1393256294	92	S>G		No	ClinGen TOPMed
CA304045335 rs999027234	93	M>T		No	ClinGen TOPMed
CA403001845 rs1325691000	93	M>V		No	ClinGen gnomAD
rs771534816 CA9044487	97	Y>C		No	ClinGen ExAC gnomAD
rs771534816 CA9044488	97	Y>F		No	ClinGen ExAC gnomAD
rs1271560845 CA403001920	99	G>S		No	ClinGen gnomAD
CA9044489 rs143917369	101	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1157193476 CA403001974	102	F>L		No	ClinGen TOPMed
rs1600268110 CA403002031	105	V>G		No	ClinGen Ensembl
rs1214202517 CA403002037	106	E>K		No	ClinGen gnomAD
rs1266457673 CA403002064	107	I>F		No	ClinGen gnomAD
rs1254108569 CA403002736	111	M>I		No	ClinGen gnomAD
rs1183122959 CA403002814	114	H>R		No	ClinGen gnomAD
rs776236475 CA9044527	115	Y>H		No	ClinGen ExAC gnomAD
rs747688084 CA9044528	117	G>S		No	ClinGen ExAC gnomAD
rs773123698 CA9044530	119	F>V		No	ClinGen ExAC gnomAD
CA403003000 rs1600268323	122	T>P		No	ClinGen Ensembl
CA9044532 rs766385001	124	K>R		No	ClinGen ExAC gnomAD
CA403003080 rs1331943831	125	P>L		No	ClinGen gnomAD
CA403003070 rs1416278447	125	P>S		No	ClinGen TOPMed
TCGA novel	126	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403003086 rs1237687989	126	V>I		No	ClinGen gnomAD
rs764367919 CA9044538	135	A>G		No	ClinGen ExAC
CA403003317 rs1456775755	138	S>F		No	ClinGen gnomAD
CA9044542 rs746319104	140	R>C		No	ClinGen ExAC gnomAD
rs747748171 CA9044545	143	P>L		No	ClinGen ExAC gnomAD
rs1600268417 CA403003406	145	K>Q		No	ClinGen Ensembl

No associated diseases with P62841

1 regional properties for P62841

Type	Name	Position	InterPro Accession
conserved_site	Ribosomal protein S15/S19, conserved site	98 - 122	IPR020934

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic ribosome	A ribosome located in the cytosol.
cytosolic small ribosomal subunit	The small subunit of a ribosome located in the cytosol.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
MDM2/MDM4 family protein binding	Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.
ubiquitin ligase inhibitor activity	Binds to and stops, prevents or reduces the activity of a ubiquitin ligase.

8 GO annotations of biological process

Name	Definition
cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
osteoblast differentiation	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
positive regulation of signal transduction by p53 class mediator	Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.
ribosomal small subunit assembly	The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
ribosomal small subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.
ribosomal small subunit export from nucleus	The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q01855	RPS15	40S ribosomal protein S15	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9FIX6	RPS15E	40S ribosomal protein S15-5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FML6	RPS15F	40S ribosomal protein S15-6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FY65	RPS15C	40S ribosomal protein S15-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FY66	RPS15B	40S ribosomal protein S15-2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q08112	RPS15A	40S ribosomal protein S15-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FY64	RPS15D	40S ribosomal protein S15-4	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MAEVEQKKKR	TFRKFTYRGV	DLDQLLDMSY	EQLMQLYSAR	QRRRLNRGLR	RKQHSLLKRL
70	80	90	100	110	120
RKAKKEAPPM	EKPEVVKTHL	RDMIILPEMV	GSMVGVYNGK	TFNQVEIKPE	MIGHYLGEFS
130	140
ITYKPVKHGR	PGIGATHSSR	FIPLK