Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P51413

Entry ID Method Resolution Chain Position Source
AF-P51413-F1 Predicted AlphaFoldDB

4 variants for P51413

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_25263098_G_A 89 A>T No 1000Genomes
tmp_1_25263260_C_T 112 A>V No 1000Genomes
tmp_1_25263481_G_A 158 V>I No 1000Genomes
tmp_1_25263583_C_A 162 P>T No 1000Genomes

No associated diseases with P51413

2 regional properties for P51413

Type Name Position InterPro Accession
domain Ribosomal protein L7/L12, oligomerisation 61 - 111 IPR008932
domain Ribosomal protein L7/L12, C-terminal 120 - 186 IPR013823

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytosolic large ribosomal subunit The large subunit of a ribosome located in the cytosol.
cytosolic ribosome A ribosome located in the cytosol.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
polysomal ribosome A ribosome bound to mRNA that forms part of a polysome.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

2 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46990 RPL17B 60S ribosomal protein L17-B Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P05740 RPL17A 60S ribosomal protein L17-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3T025 RPL17 60S ribosomal protein L17 Bos taurus (Bovine) PR
Q5XTY7 RPL17 60S ribosomal protein L17 Felis catus (Cat) (Felis silvestris catus) PR
Q9W3W8 RpL17 60S ribosomal protein L17 Drosophila melanogaster (Fruit fly) PR
P18621 RPL17 60S ribosomal protein L17 Homo sapiens (Human) PR
P24049 Rpl17 60S ribosomal protein L17 Rattus norvegicus (Rat) PR
Q5UAS2 RpL17 60S ribosomal protein L17 Bombyx mori (Silk moth) PR
Q93VI3 RPL17A 60S ribosomal protein L17-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVKYSQEPDN QTKSCKARGS DLRVHFKNTR ETAHAIRKLP LIKAKRYLED VIAHKQAIPF
70 80 90 100 110 120
TRFCRGVGRT AQAKNRHSNG QGRWPAKSAQ FVLDLLKNAE SNAEVKGLDV DALFISHIQV
130 140 150 160 170
NQAAKQRRRT YRAHGRINPY MSNPCHIELI LSEKEEPVKK EPETQLAAKS KKSAA