AiPD: Autoinhibited Protein Database

P18621

Gene name	RPL17
Protein name	60S ribosomal protein L17
Names	60S ribosomal protein L23, Large ribosomal subunit protein uL22, PD-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6139
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-184 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

128-184 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

95 structures for P18621

Entry ID	Method	Resolution	Chain	Position	Source
4UG0	EM	-	LP	1-184	PDB
4V6X	EM	500 A	CP	1-184	PDB
5A8L	EM	380 A	D	1-184	PDB
5AJ0	EM	350 A	AP	1-184	PDB
5LKS	EM	360 A	LP	1-184	PDB
5T2C	EM	360 A	J	1-160	PDB
6IP5	EM	390 A	2J	1-184	PDB
6IP6	EM	450 A	2J	1-184	PDB
6IP8	EM	390 A	2J	1-184	PDB
6LQM	EM	309 A	Y	1-184	PDB
6LSR	EM	313 A	Y	1-184	PDB
6LSS	EM	323 A	Y	1-184	PDB
6LU8	EM	313 A	Y	1-184	PDB
6OLE	EM	310 A	Q	2-154	PDB
6OLF	EM	390 A	Q	2-154	PDB
6OLG	EM	340 A	AP	2-154	PDB
6OLI	EM	350 A	Q	2-154	PDB
6OLZ	EM	390 A	AP	2-154	PDB
6OM0	EM	310 A	Q	2-154	PDB
6OM7	EM	370 A	Q	2-154	PDB
6QZP	EM	290 A	LP	2-154	PDB
6W6L	EM	384 A	Q	1-184	PDB
6XA1	EM	280 A	LP	2-154	PDB
6Y0G	EM	320 A	LP	1-184	PDB
6Y2L	EM	300 A	LP	1-184	PDB
6Y57	EM	350 A	LP	1-184	PDB
6Y6X	EM	280 A	LP	2-154	PDB
6Z6L	EM	300 A	LP	1-184	PDB
6Z6M	EM	310 A	LP	1-184	PDB
6Z6N	EM	290 A	LP	1-184	PDB
6ZM7	EM	270 A	LP	1-184	PDB
6ZME	EM	300 A	LP	1-184	PDB
6ZMI	EM	260 A	LP	1-184	PDB
6ZMO	EM	310 A	LP	1-184	PDB
7BHP	EM	330 A	LP	1-184	PDB
7F5S	EM	272 A	LP	1-184	PDB
7OW7	EM	220 A	J	1-184	PDB
7QVP	EM	300 A			PDB
7XNX	EM	270 A	LP	1-184	PDB
7XNY	EM	250 A	LP	1-184	PDB
8A3D	EM	167 A	J	1-184	PDB
8FKP	EM	285 A	LA	1-184	PDB
8FKQ	EM	276 A	LA	1-184	PDB
8FKR	EM	289 A	LA	1-184	PDB
8FKS	EM	288 A	LA	1-184	PDB
8FKT	EM	281 A	LA	1-184	PDB
8FKU	EM	282 A	LA	1-184	PDB
8FKV	EM	247 A	LA	1-184	PDB
8FKW	EM	250 A	LA	1-184	PDB
8FKX	EM	259 A	LA	1-184	PDB
8FKY	EM	267 A	LA	1-184	PDB
8FKZ	EM	304 A	LA	1-184	PDB
8FL2	EM	267 A	LA	1-184	PDB
8FL3	EM	253 A	LA	1-184	PDB
8FL4	EM	289 A	LA	1-184	PDB
8FL6	EM	262 A	LA	1-184	PDB
8FL7	EM	255 A	LA	1-184	PDB
8FL9	EM	275 A	LA	1-184	PDB
8FLA	EM	263 A	LA	1-184	PDB
8FLB	EM	255 A	LA	1-184	PDB
8FLC	EM	276 A	LA	1-184	PDB
8FLD	EM	258 A	LA	1-184	PDB
8FLE	EM	248 A	LA	1-184	PDB
8FLF	EM	265 A	LA	1-184	PDB
8G5Y	EM	229 A	LP	1-184	PDB
8G5Z	EM	264 A	LP	2-154	PDB
8G60	EM	254 A	LP	1-184	PDB
8G61	EM	294 A	LP	1-184	PDB
8G6J	EM	280 A	LP	1-184	PDB
8GLP	EM	167 A	LP	1-184	PDB
8IDT	EM	280 A	Y	1-184	PDB
8IDY	EM	300 A	Y	1-184	PDB
8IE3	EM	330 A	Y	1-184	PDB
8IFD	EM	259 A	2J	1-184	PDB
8IFE	EM	257 A	2J	1-184	PDB
8INE	EM	320 A	Y	1-184	PDB
8INF	EM	300 A	Y	1-184	PDB
8INK	EM	320 A	Y	1-184	PDB
8IPD	EM	320 A	Y	1-184	PDB
8IPX	EM	430 A	Y	1-184	PDB
8IPY	EM	320 A	Y	1-184	PDB
8IR1	EM	330 A	Y	1-184	PDB
8IR3	EM	350 A	Y	1-184	PDB
8JDJ	EM	250 A	U	1-184	PDB
8JDK	EM	226 A	U	1-184	PDB
8JDL	EM	242 A	U	1-184	PDB
8JDM	EM	267 A	U	1-184	PDB
8OHD	EM	310 A	LP	1-184	PDB
8OJ0	EM	330 A	LP	1-184	PDB
8OJ5	EM	290 A	LP	1-184	PDB
8OJ8	EM	330 A	LP	1-184	PDB
8QFD	EM	220 A	P	1-184	PDB
8Y0W	EM	340 A	LP	1-184	PDB
8Y0X	EM	330 A	LP	1-184	PDB
AF-P18621-F1	Predicted				AlphaFoldDB

115 variants for P18621

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs866030432 CA299975691	3	R>C		No	ClinGen TOPMed gnomAD
CA299975689 rs761827697	3	R>L		No	ClinGen TOPMed
rs773809547 CA8958871	4	Y>C		No	ClinGen ExAC gnomAD
CA402418037 rs1298453907	4	Y>H		No	ClinGen gnomAD
rs1600504643 CA402417965	7	D>A		No	ClinGen Ensembl
COSM1589495 COSM1589496 rs779507119 COSM1589494 CA8958868	9	E>D	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs749006339 CA8958869	9	E>G		No	ClinGen ExAC gnomAD
rs755670693 CA8958867	12	T>A		No	ClinGen ExAC gnomAD
rs1473428968 CA402417677	16	K>R		No	ClinGen gnomAD
rs757767361 CA8958847	17	S>A		No	ClinGen ExAC gnomAD
CA299975582 rs955728957	18	R>G		No	ClinGen TOPMed
rs1439776845 CA402417595	21	N>S		No	ClinGen gnomAD
CA402417561 rs1275696602	23	R>L		No	ClinGen gnomAD
CA8958794 rs749475359	29	T>A		No	ClinGen ExAC gnomAD
rs1051536381 CA299975088	30	R>C		No	ClinGen TOPMed gnomAD
rs780166361 CA8958793	30	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8958791 rs750481812	35	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1248631220 CA402417341	38	G>D		No	ClinGen gnomAD
CA402417346 rs1600500252	38	G>R		No	ClinGen Ensembl
CA402417332 rs1568503283	39	M>L		No	ClinGen Ensembl
rs1484794070 CA402417328	39	M>T		No	ClinGen gnomAD
CA402417287 rs1210326789	42	R>Q		No	ClinGen gnomAD
rs752674204 CA8958788	45	T>M		No	ClinGen ExAC gnomAD
rs1230057203 CA402417255	46	K>N		No	ClinGen gnomAD
rs1366536534 CA402417252	47	Y>H		No	ClinGen gnomAD
rs1381746311 CA402417220	51	V>A		No	ClinGen gnomAD
CA8958785 rs753489644	56	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA402417186 rs753489644	56	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA402417180 rs1465680092	57	C>G		No	ClinGen gnomAD
CA8958783 rs200887597	61	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs11537620 CA8958782	62	R>C		No	ClinGen ESP ExAC gnomAD
rs914209147 CA402417149	62	R>H		No	ClinGen TOPMed
rs914209147 CA299974983	62	R>L		No	ClinGen TOPMed
rs11537620 CA299975009	62	R>S		No	ClinGen ESP ExAC gnomAD
CA8958780 rs376740476	64	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8958781 rs376740476	64	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8958779 rs775018673	65	G>D		No	ClinGen ExAC gnomAD
CA8958778 rs562377874	66	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775723488 CA8958776	68	G>S		No	ClinGen ExAC gnomAD
rs1600499787 CA402417103	70	C>G		No	ClinGen Ensembl
rs1255028692 CA402417092	71	A>V		No	ClinGen gnomAD
rs934517618 CA299974725	73	A>V		No	ClinGen TOPMed
CA402416926 rs1350111272	74	K>E		No	ClinGen gnomAD
CA8958750 rs770958670	74	K>R		No	ClinGen ExAC TOPMed gnomAD
rs201972971 CA402416914	75	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs970934731 CA299974718	77	G>C		No	ClinGen TOPMed gnomAD
rs970934731 CA402416902	77	G>S		No	ClinGen TOPMed gnomAD
CA402416884 rs1302392850	79	T>I		No	ClinGen TOPMed
CA8958748 rs375831135	80	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1457371446 CA402416875	81	G>S		No	ClinGen gnomAD
CA8958746 rs749317178	82	R>Q		No	ClinGen ExAC gnomAD
rs1161119120 CA402416869	82	R>W		No	ClinGen gnomAD
CA402416847 rs1410852782	85	K>R		No	ClinGen gnomAD
rs779684897 CA402416837	86	K>N		No	ClinGen ExAC gnomAD
rs11537627 CA299974690	87	S>G		No	ClinGen Ensembl
rs1434441674 CA402416831	87	S>N		No	ClinGen gnomAD
rs1267480526 CA402416824	88	A>G		No	ClinGen gnomAD
CA299974684 rs990945032	89	E>D		No	ClinGen gnomAD
CA299974686 rs11537618	89	E>Q		No	ClinGen TOPMed gnomAD
CA402416814 rs1270343460	90	F>V		No	ClinGen gnomAD
rs767280121 CA8958742	93	H>D		No	ClinGen ExAC TOPMed gnomAD
rs767280121 CA8958743	93	H>N		No	ClinGen ExAC TOPMed gnomAD
CA402416789 rs963793560	94	M>L		No	ClinGen TOPMed gnomAD
CA299974668 rs963793560	94	M>V		No	ClinGen TOPMed gnomAD
CA299974663 rs763725555	98	A>S		No	ClinGen ExAC TOPMed gnomAD
CA8958739 rs763725555	98	A>T		No	ClinGen ExAC TOPMed gnomAD
rs912338898 CA299974661	98	A>V		No	ClinGen TOPMed
rs1392207428 CA402416712	105	K>E		No	ClinGen gnomAD
rs756848590 CA299973922	107	L>S		No	ClinGen Ensembl
CA8958711 rs773535881	108	D>G		No	ClinGen ExAC gnomAD
rs775228974 CA8958709	111	S>C		No	ClinGen ExAC gnomAD
rs775228974 CA8958708	111	S>Y		No	ClinGen ExAC gnomAD
rs781102933 CA8958705	114	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1412569809 CA402416638	115	E>Q		No	ClinGen gnomAD
rs746592817 CA8958703	116	H>Y		No	ClinGen ExAC gnomAD
rs1409827723 CA402416620	117	I>T		No	ClinGen TOPMed gnomAD
rs1308119413 CA402416623	117	I>V		No	ClinGen gnomAD
rs1219214022 CA402416576	123	P>L		No	ClinGen TOPMed
rs752265116 COSM1589507 CA8958699 COSM1589506 COSM1589508	126	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA402416548 rs1484167331	127	R>L		No	ClinGen gnomAD
CA402416539 rs1252547411	129	T>N		No	ClinGen gnomAD
rs1600491496 CA402416541	129	T>P		No	ClinGen Ensembl
CA402416486 rs1600491421	137	N>T		No	ClinGen Ensembl
rs1600491385 CA402416462	140	M>R		No	ClinGen Ensembl
rs766709688 CA402416447	142	S>C		No	ClinGen ExAC TOPMed gnomAD
rs766709688 CA8958695	142	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA8958694 rs756526811	144	C>G		No	ClinGen ExAC gnomAD
rs1018037092 CA402416409	146	I>F		No	ClinGen TOPMed gnomAD
CA299973836 rs1018037092	146	I>L		No	ClinGen TOPMed gnomAD
CA402416410 rs1018037092	146	I>V		No	ClinGen TOPMed gnomAD
rs767791702 CA8958692	148	M>I		No	ClinGen ExAC gnomAD
CA8958693 rs750541021	148	M>T		No	ClinGen ExAC
CA402416379 rs1165015655	150	L>I		No	ClinGen gnomAD
rs761995432 CA8958691	151	T>M		No	ClinGen ExAC TOPMed gnomAD
CA402416364 rs1440909522	151	T>S		No	ClinGen gnomAD
rs1406484538 CA402416348	153	K>E		No	ClinGen gnomAD
CA402416349 rs1406484538	153	K>Q		No	ClinGen gnomAD
CA402416317 rs1429817112	155	Q>H		No	ClinGen TOPMed gnomAD
rs1293696682 CA402416313	156	I>F		No	ClinGen TOPMed
rs1473693501 CA402416290	158	P>H		No	ClinGen TOPMed gnomAD
rs759521982 CA8958688	158	P>S		No	ClinGen ExAC gnomAD
CA402416269 rs1413054645	160	P>A		No	ClinGen gnomAD
rs1468707741 CA402416250	161	E>G		No	ClinGen TOPMed gnomAD
rs770810951 CA8958686	166	Q>*		No	ClinGen ExAC gnomAD
CA8958685 rs146823159	166	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1242894657 CA402416206	166	Q>R		No	ClinGen TOPMed
CA402415744 rs1268561865	170	I>V		No	ClinGen gnomAD
rs1214560553 CA402415737	171	S>P		No	ClinGen gnomAD
TCGA novel	178	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA402415663 rs1213205489	181	M>L		No	ClinGen TOPMed
CA8958663 rs200376678	181	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8958662 rs747818106	182	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8958660 rs768118247	183	R>Q		No	ClinGen ExAC gnomAD
rs774016585 CA8958661	183	R>W		No	ClinGen ExAC TOPMed gnomAD
rs748807979 CA8958659	184	E>*		No	ClinGen ExAC gnomAD

No associated diseases with P18621

3 regional properties for P18621

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	264 - 306	IPR001841
domain	PA domain	85 - 166	IPR003137
domain	E3 ubiquitin-protein ligase RNF149, RING finger, H2 subclass	264 - 311	IPR042712

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.
cytosolic ribosome	A ribosome located in the cytosol.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

2 GO annotations of biological process

Name	Definition
cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P46990	RPL17B	60S ribosomal protein L17-B	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P05740	RPL17A	60S ribosomal protein L17-A	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q3T025	RPL17	60S ribosomal protein L17	Bos taurus (Bovine)	PR
Q5XTY7	RPL17	60S ribosomal protein L17	Felis catus (Cat) (Felis silvestris catus)	PR
Q9W3W8	RpL17	60S ribosomal protein L17	Drosophila melanogaster (Fruit fly)	PR
P24049	Rpl17	60S ribosomal protein L17	Rattus norvegicus (Rat)	PR
Q5UAS2	RpL17	60S ribosomal protein L17	Bombyx mori (Silk moth)	PR
Q93VI3	RPL17A	60S ribosomal protein L17-1	Arabidopsis thaliana (Mouse-ear cress)	PR
P51413	RPL17B	60S ribosomal protein L17-2	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MVRYSLDPEN	PTKSCKSRGS	NLRVHFKNTR	ETAQAIKGMH	IRKATKYLKD	VTLQKQCVPF
70	80	90	100	110	120
RRYNGGVGRC	AQAKQWGWTQ	GRWPKKSAEF	LLHMLKNAES	NAELKGLDVD	SLVIEHIQVN
130	140	150	160	170	180
KAPKMRRRTY	RAHGRINPYM	SSPCHIEMIL	TEKEQIVPKP	EEEVAQKKKI	SQKKLKKQKL

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