P49578
PR
Gene name |
CHRM3 |
Protein name |
Muscarinic acetylcholine receptor M3 |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:396364 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P49578
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P49578-F1 | Predicted | AlphaFoldDB |
No variants for P49578
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P49578 | |||||
No associated diseases with P49578
1 regional properties for P49578
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Clathrin/coatomer adaptor, adaptin-like, N-terminal | 40 - 621 | IPR002553 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating adrenergic receptor signaling pathway | An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. |
| positive regulation of smooth muscle contraction | Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. |
| saliva secretion | The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30546 | HRH1 | Histamine H1 receptor | Bos taurus (Bovine) | PR |
| P41985 | CHRM2 | Muscarinic acetylcholine receptor M2 | Bos taurus (Bovine) | PR |
| P41984 | CHRM3 | Muscarinic acetylcholine receptor M3 | Bos taurus (Bovine) | PR |
| P30372 | CHRM2 | Muscarinic acetylcholine receptor M2 | Gallus gallus (Chicken) | PR |
| P17200 | CHRM4 | Muscarinic acetylcholine receptor M4 | Gallus gallus (Chicken) | PR |
| Q5IS53 | CHRM5 | Muscarinic acetylcholine receptor M5 | Pan troglodytes (Chimpanzee) | PR |
| P11229 | CHRM1 | Muscarinic acetylcholine receptor M1 | Homo sapiens (Human) | PR |
| P08912 | CHRM5 | Muscarinic acetylcholine receptor M5 | Homo sapiens (Human) | PR |
| P35367 | HRH1 | Histamine H1 receptor | Homo sapiens (Human) | PR |
| P08172 | CHRM2 | Muscarinic acetylcholine receptor M2 | Homo sapiens (Human) | PR |
| P08173 | CHRM4 | Muscarinic acetylcholine receptor M4 | Homo sapiens (Human) | PR |
| P20309 | CHRM3 | Muscarinic acetylcholine receptor M3 | Homo sapiens (Human) | PR |
| P32211 | Chrm4 | Muscarinic acetylcholine receptor M4 | Mus musculus (Mouse) | PR |
| P12657 | Chrm1 | Muscarinic acetylcholine receptor M1 | Mus musculus (Mouse) | PR |
| P70174 | Hrh1 | Histamine H1 receptor | Mus musculus (Mouse) | PR |
| Q920H4 | Chrm5 | Muscarinic acetylcholine receptor M5 | Mus musculus (Mouse) | PR |
| Q9ERZ4 | Chrm2 | Muscarinic acetylcholine receptor M2 | Mus musculus (Mouse) | PR |
| Q9ERZ3 | Chrm3 | Muscarinic acetylcholine receptor M3 | Mus musculus (Mouse) | PR |
| P04761 | CHRM1 | Muscarinic acetylcholine receptor M1 | Sus scrofa (Pig) | PR |
| P11483 | CHRM3 | Muscarinic acetylcholine receptor M3 | Sus scrofa (Pig) | PR |
| P08911 | Chrm5 | Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Rat) | PR |
| P31390 | Hrh1 | Histamine H1 receptor | Rattus norvegicus (Rat) | PR |
| P08482 | Chrm1 | Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Rat) | PR |
| P08483 | Chrm3 | Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Rat) | PR |
| P56490 | CHRM5 | Muscarinic acetylcholine receptor M5 | Macaca mulatta (Rhesus macaque) | PR |
| P56489 | CHRM1 | Muscarinic acetylcholine receptor M1 | Macaca mulatta (Rhesus macaque) | PR |
| Q9U7D5 | gar-3 | Muscarinic acetylcholine receptor gar-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTHYQLCFQ | KRSSQNYTVP | DPTSCFDVPP | WTILCQRATM | IMHNNSSALP | LFSNVSSFWK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RDSHGPGLLD | EGASLIGSYD | SPETTESFPF | STVETTNSSL | NATIKDPLGG | HAVWQVVLIA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLTGIIALVT | IIGNILVIVS | FKVNKQLKTV | NNYFLLSLAC | ADLIIGVISM | NLFTTYIIMG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HWALGNLACD | LWLSIDYVAS | NASVMNLLVI | SFDRYFSITR | PLTYRAKRTT | KRAGVMIGLA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WIISFVLWAP | AILFWQYFVG | KRTVPLDECF | IQFLSEPIIT | FGTAIAAFYL | PVTIMSILYW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RIYKETEKRT | KELAGLQASG | SEAETARFVH | QTGSSRSLSS | YELQRQSTKR | SSRRKYRRCH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FWLTMKSWEP | NTDQGDQEHS | SSDSWNNNDA | AASLENSASS | DEEDITAETR | AIYSIVLKLP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GHSAILNSTK | LPSSEDLNES | ADELQKSDTD | SQEKKPKKLQ | PPKSIQDGGS | FQKSFSKLPI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QPGSAETATA | SDGISSVTKT | SAALPLSFKE | ATLAKKFALK | TRSQITKRKR | MSLIKEKKAA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QTLSAILFAF | IITWTPYNIM | VLVNTFCDCV | PKTVWNLGYW | LCYINSTVNP | VCYALCNKMF |
| 610 | 620 | 630 | |||
| RNTFKMLLLC | QCDKRKRRKQ | QYQQRQSVIF | HKRIPREAS |