Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5IS53
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5IS53-F1 | Predicted | AlphaFoldDB |
No variants for Q5IS53
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5IS53 | |||||
No associated diseases with Q5IS53
1 regional properties for Q5IS53
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 53 - 400 | IPR017452 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| gastric acid secretion | The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30546 | HRH1 | Histamine H1 receptor | Bos taurus (Bovine) | PR |
| P41984 | CHRM3 | Muscarinic acetylcholine receptor M3 | Bos taurus (Bovine) | PR |
| P41985 | CHRM2 | Muscarinic acetylcholine receptor M2 | Bos taurus (Bovine) | PR |
| P17200 | CHRM4 | Muscarinic acetylcholine receptor M4 | Gallus gallus (Chicken) | PR |
| P49578 | CHRM3 | Muscarinic acetylcholine receptor M3 | Gallus gallus (Chicken) | PR |
| P30372 | CHRM2 | Muscarinic acetylcholine receptor M2 | Gallus gallus (Chicken) | PR |
| Q9N298 | HTR1A | 5-hydroxytryptamine receptor 1A | Pan troglodytes (Chimpanzee) | PR |
| P20309 | CHRM3 | Muscarinic acetylcholine receptor M3 | Homo sapiens (Human) | PR |
| P11229 | CHRM1 | Muscarinic acetylcholine receptor M1 | Homo sapiens (Human) | PR |
| P35367 | HRH1 | Histamine H1 receptor | Homo sapiens (Human) | PR |
| P08172 | CHRM2 | Muscarinic acetylcholine receptor M2 | Homo sapiens (Human) | PR |
| P08173 | CHRM4 | Muscarinic acetylcholine receptor M4 | Homo sapiens (Human) | PR |
| P08912 | CHRM5 | Muscarinic acetylcholine receptor M5 | Homo sapiens (Human) | PR |
| P32211 | Chrm4 | Muscarinic acetylcholine receptor M4 | Mus musculus (Mouse) | PR |
| P12657 | Chrm1 | Muscarinic acetylcholine receptor M1 | Mus musculus (Mouse) | PR |
| P70174 | Hrh1 | Histamine H1 receptor | Mus musculus (Mouse) | PR |
| Q9ERZ4 | Chrm2 | Muscarinic acetylcholine receptor M2 | Mus musculus (Mouse) | PR |
| Q9ERZ3 | Chrm3 | Muscarinic acetylcholine receptor M3 | Mus musculus (Mouse) | PR |
| Q920H4 | Chrm5 | Muscarinic acetylcholine receptor M5 | Mus musculus (Mouse) | PR |
| P04761 | CHRM1 | Muscarinic acetylcholine receptor M1 | Sus scrofa (Pig) | PR |
| P31390 | Hrh1 | Histamine H1 receptor | Rattus norvegicus (Rat) | PR |
| P08482 | Chrm1 | Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Rat) | PR |
| P08483 | Chrm3 | Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Rat) | PR |
| P08911 | Chrm5 | Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Rat) | PR |
| P56489 | CHRM1 | Muscarinic acetylcholine receptor M1 | Macaca mulatta (Rhesus macaque) | PR |
| P56490 | CHRM5 | Muscarinic acetylcholine receptor M5 | Macaca mulatta (Rhesus macaque) | PR |
| Q9U7D5 | gar-3 | Muscarinic acetylcholine receptor gar-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGDSYGNAT | TINGTPVNHQ | PLERHRLWEV | ITIAAVTAVV | SLITIVGNVL | VMISFKVNSQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKTVNNYYLL | SLACADLIIG | IFSMNLYTTY | ILMGRWALGS | LACDLWLALD | YVASNASVMN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLVISFDRYF | SITRPLTYRA | KRTPKRAGIM | IGLAWLISFI | LWAPAILCWQ | YLVGKRTVPP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DECQIQFLSE | PTITFGTAIA | AFYIPVSVMT | ILYCRIYRET | EKRTKDLADL | QGSVSVTKAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRKPAHRALF | RSCFRCPRPT | LVQRERNQAS | RSSSHRSTSI | TGKPSQATGP | STNWAKAEEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTCSSYPSSE | DEDKPATDPV | LQVVYKSQGK | ESPGEEFSAE | EAEETFVKGQ | TDKNDCDSPD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YFLSPAAAHR | PKSQQCVAYK | FQLVVKADGT | QETNNGCHKV | KIMPCSFPVA | KEPSTKGLSP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NLSHQMTKRK | RMVLVKERKA | AQTLSAILLA | FIITWTPYNI | MVLVSTFCDK | CVPVALWHLG |
| 490 | 500 | 510 | 520 | 530 | |
| YWLCYVNSTV | NPICYALCNR | TFRKTFKMLL | LCQWKKKKVE | EKLYWQGNSK | LP |