P08173
PR
Gene name |
CHRM4 |
Protein name |
Muscarinic acetylcholine receptor M4 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:1132 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
15 structures for P08173
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5DSG | X-ray | 260 A | PDB | ||
| 6D9H | EM | 360 A | R | 2-23 | PDB |
| 6KP6 | X-ray | 300 A | PDB | ||
| 7LD3 | EM | 320 A | R | 2-23 | PDB |
| 7LD4 | EM | 330 A | R | 2-23 | PDB |
| 7TRK | EM | 280 A | R | 1-479 | PDB |
| 7TRP | EM | 240 A | R | 1-479 | PDB |
| 7TRQ | EM | 250 A | R | 1-479 | PDB |
| 7TRS | EM | 280 A | R | 1-479 | PDB |
| 7V68 | EM | 340 A | R | 1-479 | PDB |
| 7V69 | EM | 340 A | R | 1-479 | PDB |
| 7V6A | EM | 360 A | R | 1-479 | PDB |
| 8E9X | EM | 270 A | A | 1-479 | PDB |
| 8FX5 | EM | 245 A | R | 1-479 | PDB |
| AF-P08173-F1 | Predicted | AlphaFoldDB |
321 variants for P08173
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA380243082 rs1407454081 |
2 | A>D | No |
ClinGen gnomAD |
|
|
rs1048059766 CA221614400 |
6 | P>L | No |
ClinGen Ensembl |
|
|
rs1565104853 CA380242975 |
6 | P>S | No |
ClinGen Ensembl |
|
|
rs1565104843 CA380242926 |
8 | N>S | No |
ClinGen Ensembl |
|
|
CA221614399 rs200113842 |
10 | S>R | No |
ClinGen TOPMed |
|
|
rs750526872 CA380242867 |
11 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750526872 CA5963912 |
11 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA221614398 rs867552583 |
12 | G>S | No |
ClinGen Ensembl |
|
|
rs754071452 CA5963909 |
13 | N>H | No |
ClinGen ExAC TOPMed |
|
|
rs759355565 CA5963907 |
14 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
rs774099897 CA5963906 |
15 | S>P | No |
ClinGen ExAC gnomAD |
|
|
rs569447371 CA380242763 |
16 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs569447371 CA5963904 |
16 | V>M | Variant assessed as Somatic; 4.646e-05 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA5963903 rs754403612 |
17 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201094203 CA221614397 |
17 | R>S | No |
ClinGen Ensembl |
|
|
rs769364189 CA5963902 |
18 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA221614396 rs199942700 |
18 | L>P | No |
ClinGen Ensembl |
|
|
rs201628810 CA221614395 |
19 | V>L | No |
ClinGen TOPMed |
|
|
CA5963901 rs200945802 |
20 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1205584433 CA380242641 |
20 | T>S | No |
ClinGen gnomAD |
|
|
rs1275501715 CA380242540 |
24 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
rs976496887 CA221614393 |
25 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs780553103 CA5963897 |
26 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA221614392 rs199535822 |
27 | Y>H | No |
ClinGen Ensembl |
|
|
CA5963896 rs200584974 |
29 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA221614388 rs200760652 |
32 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs779228087 CA5963894 |
34 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA5963893 rs757378742 |
35 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1173791093 CA380242168 |
38 | V>A | No |
ClinGen gnomAD |
|
|
rs1425342300 CA380242175 |
38 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs764337473 CA5963891 |
42 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA221614384 rs200632562 |
48 | V>M | No |
ClinGen Ensembl |
|
|
rs1279479189 CA380241893 |
53 | V>M | No |
ClinGen gnomAD |
|
|
CA380241859 rs1220967159 |
54 | M>I | No |
ClinGen gnomAD |
|
|
rs1342471234 CA380241872 |
54 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
CA5963884 rs761450770 |
58 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA221614383 rs200267822 |
58 | K>R | No |
ClinGen Ensembl |
|
|
CA380241673 rs1449260589 |
63 | L>P | No |
ClinGen TOPMed |
|
|
CA380241656 rs1301453210 |
64 | Q>R | No |
ClinGen gnomAD |
|
|
CA5963882 rs371703178 |
69 | Y>N | No |
ClinGen ESP ExAC TOPMed |
|
|
CA380241564 rs1398413301 |
69 | Y>S | No |
ClinGen gnomAD |
|
|
CA380241500 rs1159745806 |
73 | S>G | No |
ClinGen gnomAD |
|
|
rs1590682664 CA380241407 |
77 | A>D | No |
ClinGen Ensembl |
|
|
rs1565104626 CA380241388 |
78 | D>V | No |
ClinGen Ensembl |
|
|
CA221614378 rs1033644783 |
82 | G>S | No |
ClinGen Ensembl |
|
|
CA5963877 rs374767842 |
83 | A>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5963878 rs201003362 |
83 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA5963876 rs374767842 |
83 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1212338697 CA380241208 |
88 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA5963874 COSM3791510 rs777815412 |
91 | V>A | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA5963873 rs756391180 |
93 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA221614375 rs200620413 |
93 | I>V | No |
ClinGen Ensembl |
|
| TCGA novel | 94 | I>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380241084 rs1228060508 |
95 | K>E | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 95 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380241081 rs1228060508 |
95 | K>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA5963872 rs752932186 |
97 | Y>F | No |
ClinGen ExAC gnomAD |
|
|
CA380241029 rs752932186 |
97 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
CA221614373 rs750157272 |
102 | A>D | No |
ClinGen ExAC gnomAD |
|
|
CA5963869 rs750157272 |
102 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs758248044 CA380240937 |
102 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5963870 COSM3721248 rs758248044 |
102 | A>T | upper_aerodigestive_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA380240920 rs1458794885 |
103 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
| TCGA novel | 105 | C>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1474008642 CA380240824 |
106 | D>G | No |
ClinGen gnomAD |
|
|
CA380240747 rs1163844623 |
110 | A>G | No |
ClinGen gnomAD |
|
|
CA221614370 rs7107481 |
112 | D>G | No |
ClinGen Ensembl |
|
|
rs760203100 CA5963864 |
114 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1590682525 CA380240657 |
115 | V>G | No |
ClinGen Ensembl |
|
|
CA380240660 rs1304057880 |
115 | V>L | No |
ClinGen TOPMed |
|
|
CA380240602 rs1218549689 |
118 | A>T | No |
ClinGen TOPMed |
|
|
COSM1353945 rs1247534212 CA380240567 |
120 | V>I | Variant assessed as Somatic; 4.645e-05 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
| TCGA novel | 122 | N>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380240491 rs1189270594 |
124 | L>I | No |
ClinGen gnomAD |
|
|
rs1264165213 CA380240448 |
125 | I>M | No |
ClinGen gnomAD |
|
|
CA380240369 rs1590682491 |
129 | D>A | No |
ClinGen Ensembl |
|
|
CA380240355 rs1206223846 |
130 | R>C | No |
ClinGen TOPMed |
|
|
CA380240338 rs1322638523 |
130 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA221614368 rs200652468 |
133 | C>S | No |
ClinGen Ensembl |
|
| TCGA novel | 133 | C>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM1248283 rs201519376 CA5963860 |
134 | V>I | Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
| TCGA novel | 135 | T>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1590682478 CA380240264 |
135 | T>P | No |
ClinGen Ensembl |
|
|
CA5963859 rs560953877 |
139 | T>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA380240170 rs1488045482 |
140 | Y>F | No |
ClinGen TOPMed |
|
|
CA380240137 rs1283543341 |
141 | P>L | No |
ClinGen gnomAD |
|
|
rs756211061 CA5963856 |
143 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM3809272 rs200330011 CA5963857 |
143 | R>W | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA380240077 rs1336722245 |
144 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA221614366 rs202019933 |
146 | T>A | No |
ClinGen Ensembl |
|
|
rs1389730903 CA380240021 |
147 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
CA380239952 rs1421613137 |
149 | A>S | No |
ClinGen TOPMed |
|
| TCGA novel | 150 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs377675362 CA221614365 |
151 | L>V | No |
ClinGen ESP |
|
|
CA5963854 rs781520551 |
155 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA5963853 rs755134398 |
155 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 157 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 161 | F>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM927190 CA380239663 rs1248863002 |
162 | V>M | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA380239630 rs1203431490 |
163 | L>I | No |
ClinGen gnomAD |
|
|
CA380239555 COSM378960 rs1366560671 |
165 | A>V | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs1345095427 CA380239503 |
167 | A>T | No |
ClinGen gnomAD |
|
|
rs1215759352 CA380239253 |
175 | V>A | No |
ClinGen TOPMed |
|
|
CA380239272 rs1337809445 |
175 | V>M | No |
ClinGen TOPMed |
|
| TCGA novel | 177 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1309986933 CA380239188 |
178 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA380239173 rs759941649 |
179 | T>K | No |
ClinGen TOPMed gnomAD |
|
|
CA221614364 rs759941649 |
179 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA380239126 rs1590682346 |
182 | D>A | No |
ClinGen Ensembl |
|
|
CA5963845 rs200356632 COSM927189 |
182 | D>N | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA380239128 rs200356632 |
182 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5963844 rs201622884 |
183 | N>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA221614362 rs926243747 |
184 | Q>K | No |
ClinGen gnomAD |
|
|
rs771285784 CA5963842 |
184 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1590682312 CA380238850 |
192 | N>T | No |
ClinGen Ensembl |
|
|
CA5963840 rs773742760 |
194 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380238762 rs1590682294 |
196 | T>P | No |
ClinGen Ensembl |
|
|
rs1434307119 CA380238724 |
197 | F>C | No |
ClinGen gnomAD |
|
|
rs781119753 CA5963837 |
201 | I>T | No |
ClinGen ExAC |
|
|
rs970284643 CA221614359 |
204 | F>Y | No |
ClinGen Ensembl |
|
|
CA380238561 rs1590682272 |
205 | Y>S | No |
ClinGen Ensembl |
|
| TCGA novel | 208 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA221614357 rs866426141 |
212 | T>M | Variant assessed as Somatic; 4.685e-05 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1590682237 CA380238301 |
219 | S>P | No |
ClinGen Ensembl |
|
|
rs1286308322 CA380238273 |
220 | L>R | No |
ClinGen gnomAD |
|
|
rs1590682230 CA380237340 |
221 | A>P | No |
ClinGen Ensembl |
|
|
CA380237326 rs1227572969 |
222 | S>G | No |
ClinGen gnomAD |
|
|
CA5963832 rs573081535 |
223 | R>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA380237310 rs1289982482 |
223 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1393401639 CA380237278 |
225 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA5963831 rs777896843 |
225 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs756095049 CA5963830 |
226 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA380237272 rs1302363424 |
226 | V>I | No |
ClinGen gnomAD |
|
|
rs752305893 CA5963829 |
228 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA380237205 rs1157657810 |
229 | H>N | No |
ClinGen gnomAD |
|
|
rs766929725 CA380237201 |
229 | H>P | No |
ClinGen ExAC gnomAD |
|
|
rs766929725 CA5963828 |
229 | H>R | No |
ClinGen ExAC gnomAD |
|
|
COSM1734637 rs200893796 CA221614355 |
230 | R>Q | pancreas [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs759016833 CA5963827 |
230 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200034949 CA5963825 |
232 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs373521340 CA221614353 |
233 | G>S | No |
ClinGen ESP gnomAD |
|
|
CA5963822 rs369478387 |
234 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5963823 rs369478387 |
234 | P>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5963824 rs763352627 |
234 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380237141 rs763352627 |
234 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs990694285 CA221614352 |
236 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
CA5963819 rs201595336 |
236 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs747060606 CA5963818 |
238 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA221614351 rs200827665 |
241 | T>M | No |
ClinGen gnomAD |
|
| TCGA novel | 242 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1590682099 CA380236996 |
243 | A>D | No |
ClinGen Ensembl |
|
|
rs1187890206 CA380236969 |
245 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs756140306 CA5963813 |
246 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA221614350 rs199753428 |
247 | S>G | No |
ClinGen Ensembl |
|
|
CA380236942 rs1175923532 |
247 | S>N | No |
ClinGen TOPMed |
|
|
rs1207851140 CA380236881 |
252 | Q>R | No |
ClinGen gnomAD |
|
|
CA380236866 rs1265804471 |
253 | S>T | No |
ClinGen gnomAD |
|
|
CA5963809 rs200034468 |
254 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5963808 rs201531893 |
258 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1439235885 CA380236796 |
259 | P>A | No |
ClinGen gnomAD |
|
|
rs200794425 CA5963805 |
260 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1390550536 CA380236749 |
261 | E>D | No |
ClinGen gnomAD |
|
| TCGA novel | 261 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762182416 CA5963804 |
262 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs201837786 CA380236731 |
263 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5963802 rs201837786 COSM3397704 |
263 | A>T | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA5963801 rs760707328 |
264 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201253128 CA5963800 |
264 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs201253128 CA5963799 |
264 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs760707328 CA380236722 |
264 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774645111 CA5963797 |
265 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA5963798 rs199960135 |
265 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769487194 CA5963796 |
266 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747938778 CA5963795 |
268 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA380236667 rs1224372919 |
268 | R>H | No |
ClinGen gnomAD |
|
|
rs1565104182 CA380236630 |
271 | K>E | No |
ClinGen Ensembl |
|
|
CA221614349 rs888669602 |
273 | E>A | No |
ClinGen TOPMed gnomAD |
|
|
rs754924877 CA5963793 |
273 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA5963792 rs746584106 |
275 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA5963791 rs779535719 |
276 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA380236561 rs1565104171 |
276 | P>S | No |
ClinGen Ensembl |
|
|
rs201805055 CA5963790 |
277 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201805055 CA380236540 |
277 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5963789 rs201805055 |
277 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5963784 rs757593109 |
279 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380236493 rs1407109914 |
281 | P>S | No |
ClinGen gnomAD |
|
| TCGA novel | 281 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
COSM927187 rs201205429 CA5963783 |
282 | P>L | endometrium [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs1307085161 CA380236476 |
282 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA380236453 rs1284043223 |
283 | P>L | No |
ClinGen TOPMed |
|
| TCGA novel | 283 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA221614344 rs200784550 |
284 | P>L | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs552730458 CA5963780 |
285 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs767705653 CA5963779 |
285 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380236416 rs1250784152 |
286 | P>L | No |
ClinGen gnomAD |
|
|
CA380236393 rs1275266692 |
287 | V>E | No |
ClinGen gnomAD |
|
|
rs533484145 CA5963776 |
287 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs1198755309 CA380236254 |
295 | E>G | No |
ClinGen gnomAD |
|
|
rs1284416766 CA380236211 |
299 | G>S | No |
ClinGen gnomAD |
|
|
CA221614343 rs992834187 |
300 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA221614342 rs779899442 |
300 | S>R | No |
ClinGen Ensembl |
|
| TCGA novel | 300 | S>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 303 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs567060019 CA5963773 |
304 | N>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA380236092 rs1429419052 |
307 | E>D | No |
ClinGen TOPMed |
|
|
rs746953631 CA5963772 |
308 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA5963771 rs779910035 |
308 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA380236044 rs1413340341 |
310 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA380235984 rs1421121419 |
315 | T>N | No |
ClinGen TOPMed |
|
|
CA5963769 rs745344508 |
316 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA380235966 rs1410183047 |
317 | E>K | No |
ClinGen TOPMed |
|
|
rs1234781787 CA380235943 |
318 | A>S | No |
ClinGen gnomAD |
|
|
CA380235904 rs1441861022 |
320 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA380235896 rs1206163369 |
321 | P>T | No |
ClinGen gnomAD |
|
|
CA5963764 rs201272067 |
322 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs201272067 CA5963765 |
322 | A>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA380235868 rs1339955805 |
322 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1271995958 CA380235849 |
323 | M>I | No |
ClinGen TOPMed |
|
|
CA380235860 rs753267557 |
323 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1238507 rs753267557 CA5963763 |
323 | M>V | oesophagus [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1340390603 CA380235837 |
324 | P>S | No |
ClinGen TOPMed |
|
|
COSM340341 rs952822213 CA221614340 |
325 | A>T | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA5963761 rs759733224 |
326 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA380235799 rs1282006055 |
326 | P>S | No |
ClinGen gnomAD |
|
|
CA5963760 rs199709266 |
327 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs199709266 CA221614339 |
327 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1490931827 CA380235792 |
327 | P>S | No |
ClinGen TOPMed |
|
|
rs763235994 CA5963758 |
328 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763235994 CA380235782 |
328 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs997356160 CA380235764 CA221614338 |
329 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
COSM239326 rs1159673748 CA380235748 |
330 | P>L | Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs200850651 CA380235744 |
331 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA5963756 COSM542744 rs199586286 |
331 | R>P | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA5963755 rs199586286 |
331 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM927183 CA221614337 rs200850651 |
331 | R>W | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA380235701 rs1175131873 |
334 | N>K | No |
ClinGen Ensembl |
|
| TCGA novel | 334 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 335 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1565103983 CA380235670 |
336 | A>V | No |
ClinGen Ensembl |
|
|
CA221614336 rs1007911460 |
338 | R>G | No |
ClinGen gnomAD |
|
|
CA380235653 rs1243872011 |
338 | R>K | No |
ClinGen gnomAD |
|
|
CA380235592 rs745430456 |
341 | K>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5963752 rs745430456 |
341 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs377125659 CA5963751 |
344 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1216974790 CA380235523 |
345 | V>L | No |
ClinGen gnomAD |
|
|
CA221614335 rs191392166 |
346 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5963750 rs191392166 |
346 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1227427518 CA380235485 |
347 | K>N | No |
ClinGen gnomAD |
|
| TCGA novel | 348 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380235462 rs200571918 |
349 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs200571918 CA5963748 |
349 | T>R | No |
ClinGen ExAC gnomAD |
|
|
rs1455811105 CA380235463 |
349 | T>S | No |
ClinGen Ensembl |
|
|
CA380235447 rs1364383290 |
350 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs756567031 CA5963747 |
350 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs753069194 CA221614333 |
351 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1362060729 CA380235411 |
352 | E>D | No |
ClinGen TOPMed |
|
|
CA380235406 rs1247092670 |
353 | C>S | No |
ClinGen TOPMed |
|
|
CA380235401 rs1347939321 |
353 | C>Y | No |
ClinGen gnomAD |
|
|
rs1049106481 CA221614332 |
356 | A>S | No |
ClinGen TOPMed |
|
| TCGA novel | 358 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781777462 CA5963745 |
359 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1424284498 CA380235314 |
360 | V>M | No |
ClinGen gnomAD |
|
|
rs755530650 CA5963744 |
362 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs201134515 CA5963743 |
363 | T>M | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5963741 rs200255240 |
364 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200255240 CA5963742 |
364 | P>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA221614329 rs948830893 |
364 | P>S | No |
ClinGen Ensembl |
|
|
rs201677925 CA5963739 |
367 | M>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5963738 rs760504636 |
368 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201538954 CA5963737 |
368 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA380235250 COSM1127787 rs760504636 |
368 | R>S | prostate [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA5963735 rs200461648 |
370 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA221614328 rs938936253 |
372 | N>D | No |
ClinGen Ensembl |
|
|
rs1340920341 CA380235211 |
372 | N>S | No |
ClinGen gnomAD |
|
|
rs375771904 CA5963732 |
373 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
CA5963730 rs769549870 |
375 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs781689933 CA5963729 |
375 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5963728 rs781689933 |
375 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA380235153 rs750280509 |
378 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750280509 CA5963726 COSM927182 |
378 | A>T | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1171199868 CA380235124 |
381 | A>T | No |
ClinGen gnomAD |
|
|
rs373404528 CA221614327 |
382 | R>C | No |
ClinGen ESP gnomAD |
|
|
CA380235111 rs1423637928 |
382 | R>H | No |
ClinGen gnomAD |
|
|
CA5963723 rs750441178 |
384 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA380235086 rs1309036260 |
384 | Q>H | No |
ClinGen TOPMed |
|
|
rs202126623 CA221614326 |
386 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA5963722 rs201099319 |
386 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs767304246 CA5963719 |
389 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1205956341 CA380235043 |
389 | R>W | No |
ClinGen gnomAD |
|
|
CA380235007 rs1300432545 |
392 | A>V | No |
ClinGen gnomAD |
|
|
CA5963717 rs376964131 |
393 | A>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5963716 rs376964131 |
393 | A>V | Variant assessed as Somatic; 0.0001858 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA380234993 rs772586917 |
394 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1395969075 CA380234992 |
394 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs772586917 CA5963714 |
394 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1183798605 CA380234979 |
395 | E>D | No |
ClinGen TOPMed |
|
|
CA5963713 rs769639848 |
396 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA221614325 rs200901598 |
400 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
COSM229776 CA5963706 rs746016944 |
411 | L>F | Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA5963705 rs370900717 |
414 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 417 | N>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs200588248 CA5963702 COSM927181 |
418 | V>I | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 420 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 426 | C>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA221614322 rs199633583 |
433 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1377116100 CA380234388 |
434 | V>L | No |
ClinGen gnomAD |
|
|
CA380234333 rs1408859644 |
439 | Y>* | No |
ClinGen gnomAD |
|
|
rs761358369 CA5963695 |
444 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA221614321 rs201891549 |
446 | S>G | No |
ClinGen 1000Genomes |
|
|
CA380234123 rs1207899036 |
460 | F>L | No |
ClinGen gnomAD |
|
| TCGA novel | 464 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1262238805 CA380234065 COSM927177 |
465 | R>Q | endometrium [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs200267035 CA5963689 |
465 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 466 | H>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA380234025 rs1305842856 |
470 | C>R | No |
ClinGen gnomAD |
|
|
COSM3397703 rs201159443 CA5963686 |
473 | R>Q | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs201602666 CA5963687 |
473 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5963683 rs751439550 |
476 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs758155756 CA5963681 |
477 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA380233945 rs1384147923 |
478 | A>D | No |
ClinGen gnomAD |
|
|
rs1375548060 CA380233940 |
479 | R>G | No |
ClinGen gnomAD |
No associated diseases with P08173
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| G protein-coupled serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process. |
| cell surface receptor signaling pathway | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| G protein-coupled acetylcholine receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription. |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. |
| regulation of locomotion | Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30546 | HRH1 | Histamine H1 receptor | Bos taurus (Bovine) | PR |
| P41984 | CHRM3 | Muscarinic acetylcholine receptor M3 | Bos taurus (Bovine) | PR |
| P41985 | CHRM2 | Muscarinic acetylcholine receptor M2 | Bos taurus (Bovine) | PR |
| P49578 | CHRM3 | Muscarinic acetylcholine receptor M3 | Gallus gallus (Chicken) | PR |
| P30372 | CHRM2 | Muscarinic acetylcholine receptor M2 | Gallus gallus (Chicken) | PR |
| P17200 | CHRM4 | Muscarinic acetylcholine receptor M4 | Gallus gallus (Chicken) | PR |
| Q5IS53 | CHRM5 | Muscarinic acetylcholine receptor M5 | Pan troglodytes (Chimpanzee) | PR |
| P08172 | CHRM2 | Muscarinic acetylcholine receptor M2 | Homo sapiens (Human) | PR |
| P08912 | CHRM5 | Muscarinic acetylcholine receptor M5 | Homo sapiens (Human) | PR |
| P20309 | CHRM3 | Muscarinic acetylcholine receptor M3 | Homo sapiens (Human) | PR |
| P35367 | HRH1 | Histamine H1 receptor | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P11229 | CHRM1 | Muscarinic acetylcholine receptor M1 | Homo sapiens (Human) | PR |
| P70174 | Hrh1 | Histamine H1 receptor | Mus musculus (Mouse) | PR |
| P12657 | Chrm1 | Muscarinic acetylcholine receptor M1 | Mus musculus (Mouse) | PR |
| Q9ERZ3 | Chrm3 | Muscarinic acetylcholine receptor M3 | Mus musculus (Mouse) | PR |
| P32211 | Chrm4 | Muscarinic acetylcholine receptor M4 | Mus musculus (Mouse) | PR |
| Q920H4 | Chrm5 | Muscarinic acetylcholine receptor M5 | Mus musculus (Mouse) | PR |
| Q9ERZ4 | Chrm2 | Muscarinic acetylcholine receptor M2 | Mus musculus (Mouse) | PR |
| P04761 | CHRM1 | Muscarinic acetylcholine receptor M1 | Sus scrofa (Pig) | PR |
| P31390 | Hrh1 | Histamine H1 receptor | Rattus norvegicus (Rat) | PR |
| P08483 | Chrm3 | Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Rat) | PR |
| P08482 | Chrm1 | Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Rat) | PR |
| P08911 | Chrm5 | Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Rat) | PR |
| P56489 | CHRM1 | Muscarinic acetylcholine receptor M1 | Macaca mulatta (Rhesus macaque) | PR |
| P56490 | CHRM5 | Muscarinic acetylcholine receptor M5 | Macaca mulatta (Rhesus macaque) | PR |
| Q9U7D5 | gar-3 | Muscarinic acetylcholine receptor gar-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MANFTPVNGS | SGNQSVRLVT | SSSHNRYETV | EMVFIATVTG | SLSLVTVVGN | ILVMLSIKVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RQLQTVNNYF | LFSLACADLI | IGAFSMNLYT | VYIIKGYWPL | GAVVCDLWLA | LDYVVSNASV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MNLLIISFDR | YFCVTKPLTY | PARRTTKMAG | LMIAAAWVLS | FVLWAPAILF | WQFVVGKRTV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PDNQCFIQFL | SNPAVTFGTA | IAAFYLPVVI | MTVLYIHISL | ASRSRVHKHR | PEGPKEKKAK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TLAFLKSPLM | KQSVKKPPPG | EAAREELRNG | KLEEAPPPAL | PPPPRPVADK | DTSNESSSGS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ATQNTKERPA | TELSTTEATT | PAMPAPPLQP | RALNPASRWS | KIQIVTKQTG | NECVTAIEIV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PATPAGMRPA | ANVARKFASI | ARNQVRKKRQ | MAARERKVTR | TIFAILLAFI | LTWTPYNVMV |
| 430 | 440 | 450 | 460 | 470 | |
| LVNTFCQSCI | PDTVWSIGYW | LCYVNSTINP | ACYALCNATF | KKTFRHLLLC | QYRNIGTAR |