P70174
PR
Gene name |
Hrh1 (Bphs) |
Protein name |
Histamine H1 receptor |
Names |
H1R, HH1R |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:15465 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P70174
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P70174-F1 | Predicted | AlphaFoldDB |
27 variants for P70174
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388816387 | 3 | L>H | No | EVA | |
| rs3388852351 | 20 | T>R | No | EVA | |
| rs581709124 | 53 | R>H | No | EVA | |
| rs3388833030 | 68 | S>C | No | EVA | |
| rs3388846511 | 72 | A>S | No | EVA | |
| rs3388829774 | 114 | S>P | No | EVA | |
| rs3388846506 | 146 | A>D | No | EVA | |
| rs3388854529 | 153 | F>Y | No | EVA | |
| rs3388849322 | 163 | L>R | No | EVA | |
| rs3388845256 | 167 | H>L | No | EVA | |
| rs3388816333 | 179 | K>E | No | EVA | |
| rs3388854502 | 201 | L>H | No | EVA | |
| rs3388852258 | 223 | H>D | No | EVA | |
| rs3397211611 | 261 | K>* | No | EVA | |
| rs46439552 | 263 | P>L | strain: C3H/HeJ and CBA/J [UniProt] | No | EVA |
| rs3388849286 | 278 | E>D | No | EVA | |
| rs584656312 | 299 | R>C | No | EVA | |
| rs584656312 | 299 | R>S | No | EVA | |
| rs3388841736 | 306 | V>A | No | EVA | |
| rs3388833005 | 307 | M>I | No | EVA | |
| rs3388850988 | 309 | T>A | No | EVA | |
| rs8243440 | 312 | V>M | strain: C3H/HeJ and CBA/J [UniProt] | No | EVA |
| rs8243439 | 330 | P>S | strain: C3H/HeJ and CBA/J [UniProt] | No | EVA |
| rs3388853443 | 361 | T>S | No | EVA | |
| rs3388833039 | 417 | Q>H | No | EVA | |
| rs3388850944 | 428 | C>Y | No | EVA | |
| rs3388841690 | 462 | S>P | No | EVA |
No associated diseases with P70174
1 regional properties for P70174
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Clathrin/coatomer adaptor, adaptin-like, N-terminal | 40 - 621 | IPR002553 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion transmembrane transporter activity | Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. |
| G protein-coupled serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
| histamine binding | Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
| histamine receptor activity | Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion import | The directed movement of calcium ions into a cell or organelle. |
| cellular response to histamine | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| eosinophil chemotaxis | The movement of an eosinophil in response to an external stimulus. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. |
| manganese ion transmembrane transport | A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| memory | The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). |
| negative regulation of steroid biosynthetic process | Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
| positive regulation of nitric oxide biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. |
| positive regulation of vasoconstriction | Any process that activates or increases the frequency, rate or extent of vasoconstriction. |
| regulation of synaptic plasticity | A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. |
| regulation of vascular permeability | Any process that modulates the extent to which blood vessels can be pervaded by fluid. |
| rhythmic process | Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. |
| visual learning | Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41984 | CHRM3 | Muscarinic acetylcholine receptor M3 | Bos taurus (Bovine) | PR |
| P41985 | CHRM2 | Muscarinic acetylcholine receptor M2 | Bos taurus (Bovine) | PR |
| P30546 | HRH1 | Histamine H1 receptor | Bos taurus (Bovine) | PR |
| P17200 | CHRM4 | Muscarinic acetylcholine receptor M4 | Gallus gallus (Chicken) | PR |
| P49578 | CHRM3 | Muscarinic acetylcholine receptor M3 | Gallus gallus (Chicken) | PR |
| P30372 | CHRM2 | Muscarinic acetylcholine receptor M2 | Gallus gallus (Chicken) | PR |
| Q5IS53 | CHRM5 | Muscarinic acetylcholine receptor M5 | Pan troglodytes (Chimpanzee) | PR |
| P20309 | CHRM3 | Muscarinic acetylcholine receptor M3 | Homo sapiens (Human) | PR |
| P11229 | CHRM1 | Muscarinic acetylcholine receptor M1 | Homo sapiens (Human) | PR |
| P08912 | CHRM5 | Muscarinic acetylcholine receptor M5 | Homo sapiens (Human) | PR |
| P08172 | CHRM2 | Muscarinic acetylcholine receptor M2 | Homo sapiens (Human) | PR |
| P08173 | CHRM4 | Muscarinic acetylcholine receptor M4 | Homo sapiens (Human) | PR |
| P35367 | HRH1 | Histamine H1 receptor | Homo sapiens (Human) | PR |
| P12657 | Chrm1 | Muscarinic acetylcholine receptor M1 | Mus musculus (Mouse) | PR |
| P32211 | Chrm4 | Muscarinic acetylcholine receptor M4 | Mus musculus (Mouse) | PR |
| Q920H4 | Chrm5 | Muscarinic acetylcholine receptor M5 | Mus musculus (Mouse) | PR |
| Q9ERZ3 | Chrm3 | Muscarinic acetylcholine receptor M3 | Mus musculus (Mouse) | PR |
| Q9ERZ4 | Chrm2 | Muscarinic acetylcholine receptor M2 | Mus musculus (Mouse) | PR |
| Q64264 | Htr1a | 5-hydroxytryptamine receptor 1A | Mus musculus (Mouse) | PR |
| P97292 | Hrh2 | Histamine H2 receptor | Mus musculus (Mouse) | PR |
| Q91ZY2 | Hrh4 | Histamine H4 receptor | Mus musculus (Mouse) | PR |
| P04761 | CHRM1 | Muscarinic acetylcholine receptor M1 | Sus scrofa (Pig) | PR |
| P08911 | Chrm5 | Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Rat) | PR |
| P08482 | Chrm1 | Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Rat) | PR |
| P08483 | Chrm3 | Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Rat) | PR |
| P31390 | Hrh1 | Histamine H1 receptor | Rattus norvegicus (Rat) | PR |
| P56490 | CHRM5 | Muscarinic acetylcholine receptor M5 | Macaca mulatta (Rhesus macaque) | PR |
| P56489 | CHRM1 | Muscarinic acetylcholine receptor M1 | Macaca mulatta (Rhesus macaque) | PR |
| Q9U7D5 | gar-3 | Muscarinic acetylcholine receptor gar-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLPNTSSAS | EDKMCEGNRT | AMASPQLLPL | VVVLSSISLV | TVGLNLLVLY | AVRSERKLHT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGNLYIVSLS | VADLIVGAVV | MPMNILYLIM | TKWSLGRPLC | LFWLSMDYVA | STASIFSVFI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LCIDRYRSVQ | QPLRYLRYRT | KTRASATILG | AWFLSFLWVI | PILGWHHFTP | LAPELREDKC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETDFYNVTWF | KIMTAIINFY | LPTLLMLWFY | VKIYKAVRRH | CQHRQLTNGS | LPTFLEIKLR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SEDAKEGAKK | PGKESPWGVQ | KRPSRDPTGG | LDQKSTSEDP | KVTSPTVFSQ | EGERETVTRP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CFRLDVMQTQ | PVPEGDARGS | KANDQTLSQP | KMDEQSLSTC | RRISETSEDQ | TLVDRQSFSR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TTDSDTSIEP | GLGKVKARSR | SNSGLDYIKV | TWKRLRSHSR | QYVSGLHLNR | ERKAAKQLGC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IMAAFILCWI | PYFIFFMVIA | FCNSCCSEPV | HMFTIWLGYI | NSTLNPLIYP | LCNENFKKTF |
| KKILHIRS |