P08912
PR
Gene name |
CHRM5 |
Protein name |
Muscarinic acetylcholine receptor M5 |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:1133 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P08912
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6OL9 | X-ray | 254 A | PDB | ||
| AF-P08912-F1 | Predicted | AlphaFoldDB |
376 variants for P08912
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA391601008 rs1202147910 |
3 | G>E | No |
ClinGen TOPMed |
|
|
CA7462566 rs769513293 |
6 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs778712394 CA7462565 |
6 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462567 rs772815473 |
9 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391601051 rs772815473 |
9 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391601061 rs1303811935 |
11 | T>N | No |
ClinGen gnomAD |
|
|
rs759462080 CA7462571 |
12 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767530640 CA391601073 |
13 | N>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767530640 CA7462572 |
13 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462574 rs141408054 |
16 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7462573 rs111448827 |
16 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs770980808 CA268598893 |
18 | N>Y | No |
ClinGen Ensembl |
|
|
CA7462575 rs778087279 |
19 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA268598953 rs958054721 |
21 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA7462577 rs757707285 |
21 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs757707285 CA391601120 |
21 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA7462578 COSM960769 rs571543498 |
24 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1389722827 CA391601141 |
24 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs571543498 CA391601139 |
24 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7462579 rs746417976 |
29 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1386122008 CA391601187 |
30 | V>D | No |
ClinGen gnomAD |
|
|
CA391601182 rs1388695811 |
30 | V>I | No |
ClinGen gnomAD |
|
|
rs772610553 CA7462580 |
31 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 32 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7462582 rs747729875 |
32 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs1296613659 CA391601203 |
33 | I>T | No |
ClinGen gnomAD |
|
|
rs769123399 CA7462583 |
35 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1229190809 CA391601218 |
36 | V>L | No |
ClinGen gnomAD |
|
|
rs772868482 CA7462584 |
37 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs762582950 CA7462585 |
39 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs770776737 CA7462586 |
42 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA391601259 rs1254247744 |
43 | I>F | No |
ClinGen gnomAD |
|
|
CA268599015 rs781435131 |
43 | I>N | No |
ClinGen Ensembl |
|
|
CA391601273 rs1261513833 |
45 | I>T | No |
ClinGen gnomAD |
|
| TCGA novel | 47 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7462587 COSM1323238 rs774098229 |
50 | L>F | ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA7462588 rs137922280 |
52 | M>I | No |
ClinGen ESP ExAC TOPMed |
|
|
CA391601318 rs1172869026 |
52 | M>T | No |
ClinGen gnomAD |
|
|
CA7462589 rs78383790 |
53 | I>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs775251308 CA7462590 |
54 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs77491512 CA268599045 |
55 | F>L | No |
ClinGen TOPMed |
|
|
CA391601348 rs1165544868 |
57 | V>I | No |
ClinGen gnomAD |
|
|
CA391601366 rs1432811123 |
59 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
CA7462592 rs764211174 |
61 | L>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 62 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA391601407 rs1309073991 |
65 | N>S | No |
ClinGen gnomAD |
|
|
rs1344278002 CA391601464 |
73 | A>D | No |
ClinGen TOPMed |
|
|
rs765747758 CA7462595 |
74 | C>Y | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 75 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs750841044 CA7462596 |
76 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA391601505 rs1233307744 |
79 | I>T | No |
ClinGen TOPMed gnomAD |
|
|
CA391601540 rs1337536950 COSM1236745 |
84 | M>I | pancreas [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1274511792 CA391601539 |
84 | M>T | No |
ClinGen gnomAD |
|
|
rs758654227 CA7462597 |
86 | L>I | No |
ClinGen ExAC gnomAD |
|
|
CA391601575 rs1260480118 |
89 | T>I | No |
ClinGen gnomAD |
|
| TCGA novel | 92 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 92 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7462600 rs755710294 |
95 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1475008854 COSM554673 CA391601614 |
95 | R>H | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
| TCGA novel | 96 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA391601626 rs1188660374 |
97 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1420151622 CA391601631 |
97 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs777258099 CA7462601 |
98 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748975974 CA7462602 |
98 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1567494122 CA391601636 |
99 | G>R | No |
ClinGen Ensembl |
|
|
CA268599151 rs367857442 |
100 | S>G | No |
ClinGen ESP TOPMed gnomAD |
|
| TCGA novel | 102 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs878903159 CA268599195 |
102 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs371168058 CA7462604 |
102 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs982177022 CA268599223 |
103 | C>Y | No |
ClinGen Ensembl |
|
| TCGA novel | 104 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs745706794 CA7462605 |
104 | D>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 105 | L>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs771696857 CA7462606 |
106 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs775509079 CA7462607 |
109 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1227060620 CA391601699 |
109 | L>V | No |
ClinGen gnomAD |
|
|
rs1450361764 CA391601706 |
110 | D>G | No |
ClinGen gnomAD |
|
|
rs746108100 CA7462609 |
112 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1211891263 CA391601745 |
116 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
COSM319455 rs1251321713 CA391601759 |
118 | V>F | lung [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA7462612 rs765587498 |
119 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA391601793 rs1019440264 |
123 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1019440264 CA268599264 |
123 | V>E | No |
ClinGen TOPMed gnomAD |
|
|
CA7462613 rs368522225 |
125 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs766642500 CA7462615 |
128 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA7462616 rs752179210 |
128 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs994460733 CA268599293 |
132 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1434926817 CA391601888 |
137 | T>I | No |
ClinGen gnomAD |
|
|
rs372901279 CA7462618 |
139 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7462617 rs372901279 |
139 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1288575176 CA391601898 |
139 | R>W | No |
ClinGen TOPMed |
|
|
rs375495476 CA7462619 |
141 | K>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7462620 rs200634273 COSM77472 |
142 | R>C | ovary large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs200634273 CA7462621 |
142 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1226004026 CA391601914 |
142 | R>H | No |
ClinGen gnomAD |
|
|
CA268599339 rs769848110 COSM1580708 |
144 | P>A | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs146231539 CA7462622 |
144 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA268599340 rs146231539 |
144 | P>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs369937575 CA7462624 |
145 | K>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA391601926 rs369937575 |
145 | K>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1482207132 CA391601939 |
146 | R>S | No |
ClinGen gnomAD |
|
|
CA391601947 rs1411576139 |
148 | G>S | No |
ClinGen TOPMed |
|
|
CA391601961 rs1233556277 |
150 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1473655817 CA391601963 |
150 | M>T | No |
ClinGen TOPMed |
|
|
rs1233556277 CA391601960 |
150 | M>V | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 152 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA268599360 rs916279192 |
152 | G>V | No |
ClinGen TOPMed |
|
|
CA391602037 rs1175111187 |
161 | L>V | No |
ClinGen gnomAD |
|
|
CA391602065 rs1328240583 |
165 | A>V | No |
ClinGen TOPMed |
|
|
CA391602068 rs1268452803 |
166 | I>V | No |
ClinGen TOPMed |
|
|
CA7462629 rs148191916 |
167 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA391602084 rs1409014295 |
168 | C>F | No |
ClinGen gnomAD |
|
|
rs1328896835 CA391602091 |
169 | W>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 175 | K>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1320914793 CA391602135 |
175 | K>T | No |
ClinGen TOPMed |
|
|
CA7462631 rs773544114 |
176 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769941156 CA7462630 |
176 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA7462633 rs766804444 |
178 | V>D | No |
ClinGen ExAC gnomAD |
|
|
rs1370704585 CA391602151 |
178 | V>F | No |
ClinGen gnomAD |
|
|
CA391602154 rs1306096452 |
179 | P>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA391602163 rs1340257918 |
180 | L>P | No |
ClinGen gnomAD |
|
|
rs1214230364 CA391602179 |
182 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
CA7462634 rs751845261 |
183 | C>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1433452311 CA391602219 |
188 | L>F | No |
ClinGen TOPMed |
|
| TCGA novel | 190 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7462636 rs768040535 |
192 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA7462639 rs778271152 |
197 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs1049755751 CA268599464 |
199 | I>T | No |
ClinGen TOPMed |
|
|
rs779710796 CA7462642 |
199 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1420985408 CA391602301 |
201 | A>S | No |
ClinGen gnomAD |
|
|
rs1394309313 CA391602326 |
204 | I>N | No |
ClinGen gnomAD |
|
| TCGA novel | 204 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 207 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 207 | S>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1328286304 CA391602347 |
208 | V>L | No |
ClinGen gnomAD |
|
|
CA268599466 rs1008302096 |
209 | M>V | No |
ClinGen TOPMed |
|
|
CA7462648 rs199681177 |
211 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs1597395945 CA391602372 |
212 | L>I | No |
ClinGen Ensembl |
|
|
rs773138215 CA7462649 |
214 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
CA7462650 rs763280962 COSM1678337 |
215 | R>* | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA7462652 COSM960775 rs774588600 |
215 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs541902330 CA7462654 |
218 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs574531423 CA7462653 |
218 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1024030545 CA268599494 |
219 | E>D | No |
ClinGen Ensembl |
|
|
CA7462656 rs753260999 |
219 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA391602443 rs1482092786 |
223 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA268599495 COSM960776 rs749608809 |
223 | R>Q | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA391602466 rs1167787583 |
226 | D>E | No |
ClinGen gnomAD |
|
|
CA391602462 rs1462405930 |
226 | D>Y | No |
ClinGen gnomAD |
|
|
CA7462659 rs749924788 |
227 | L>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1313450341 CA391602476 |
228 | A>G | No |
ClinGen TOPMed |
|
|
CA7462661 rs779578047 |
229 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751199391 CA7462662 |
230 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1597396006 CA391602489 |
230 | L>R | No |
ClinGen Ensembl |
|
|
rs754882320 CA7462663 |
232 | G>C | No |
ClinGen ExAC gnomAD |
|
|
rs754882320 CA268599509 |
232 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA391602510 rs1365038917 |
234 | D>Y | No |
ClinGen TOPMed |
|
|
CA268599517 rs973017331 |
235 | S>P | No |
ClinGen TOPMed |
|
|
CA391602532 rs1231896104 |
237 | T>I | No |
ClinGen gnomAD |
|
|
rs1567494443 CA391602546 |
239 | A>V | No |
ClinGen Ensembl |
|
|
rs748139020 CA7462665 |
241 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462666 rs769593960 |
242 | R>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs769263866 CA268599549 |
248 | A>V | No |
ClinGen Ensembl |
|
|
rs140851264 CA7462670 |
255 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376737817 CA7462672 |
255 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs376737817 CA7462671 |
255 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1475941647 CA391602657 |
256 | C>F | No |
ClinGen gnomAD |
|
|
CA391602667 rs1190681112 |
258 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs760980577 CA7462674 |
258 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1470076996 CA391602681 |
260 | T>I | No |
ClinGen gnomAD |
|
|
rs1159468531 CA391602682 |
261 | L>M | No |
ClinGen gnomAD |
|
|
CA391602692 rs1410650159 |
262 | A>V | No |
ClinGen gnomAD |
|
|
CA391602693 rs1433063698 |
263 | Q>K | No |
ClinGen gnomAD |
|
|
CA7462676 rs777128975 |
264 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA7462675 rs764541495 |
264 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462677 rs762383940 |
266 | R>K | No |
ClinGen ExAC gnomAD |
|
|
TCGA novel rs1239713658 CA391602731 |
268 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen gnomAD NCI-TCGA |
|
CA7462678 rs145732165 |
268 | Q>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200786354 CA7462679 |
269 | A>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA391602743 rs1345518801 |
270 | S>C | No |
ClinGen gnomAD |
|
|
CA7462682 rs752560317 |
271 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767472455 CA7462681 |
271 | W>S | No |
ClinGen ExAC gnomAD |
|
|
CA7462683 rs755895467 |
275 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs777572782 CA7462684 |
275 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391602774 rs1271885825 |
276 | R>G | No |
ClinGen TOPMed |
|
|
rs1365875661 CA391602783 |
277 | S>N | No |
ClinGen gnomAD |
|
|
CA7462686 rs1555521392 |
278 | T>P | No |
ClinGen Ensembl |
|
|
rs914764876 CA268599654 |
281 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
CA391602827 rs1395929593 |
284 | P>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA391602825 rs1157077187 |
284 | P>S | No |
ClinGen gnomAD |
|
|
CA7462689 rs757339104 |
285 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA7462690 rs778959312 |
289 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA391602871 rs1312406713 |
291 | S>I | No |
ClinGen TOPMed |
|
|
rs377423553 CA7462691 |
292 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7462693 rs148495102 |
293 | N>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462692 rs148495102 |
293 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1224814668 CA391602894 |
295 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA391602895 rs1224814668 |
295 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs142978946 CA268599692 |
302 | T>I | No |
ClinGen ESP TOPMed |
|
|
CA7462696 rs777064271 |
303 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391602947 rs777064271 |
303 | C>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391602975 rs1456264132 |
306 | Y>* | No |
ClinGen TOPMed |
|
|
rs937944360 CA268599710 |
306 | Y>S | No |
ClinGen Ensembl |
|
|
rs1367706605 CA391602982 |
307 | P>L | No |
ClinGen TOPMed |
|
|
CA391602979 rs1240631999 |
307 | P>S | No |
ClinGen gnomAD |
|
|
rs765851212 CA7462698 |
310 | E>A | No |
ClinGen ExAC gnomAD |
|
|
CA7462699 rs773978770 |
311 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs374089666 CA7462700 |
313 | D>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs767306890 CA7462701 |
314 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1597396207 CA391603027 |
314 | K>R | No |
ClinGen Ensembl |
|
|
CA391603038 rs141362421 |
316 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA7462703 rs141362421 COSM433735 |
316 | A>T | breast [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs763934955 CA7462704 |
321 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA391603078 rs1234875988 |
322 | Q>H | No |
ClinGen gnomAD |
|
|
rs753785210 CA7462705 |
322 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs762280733 CA7462706 |
323 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs1277421004 CA391603089 |
324 | V>A | No |
ClinGen gnomAD |
|
|
rs1294484353 CA391603094 |
325 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs779012334 CA7462707 |
325 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs1326489575 CA391603107 |
327 | S>G | No |
ClinGen gnomAD |
|
|
rs1270763778 CA391603119 |
328 | Q>H | No |
ClinGen gnomAD |
|
|
CA7462708 rs745980649 |
328 | Q>P | No |
ClinGen ExAC gnomAD |
|
|
rs145125191 CA7462709 |
329 | G>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs780268468 CA7462710 COSM1707972 |
329 | G>D | skin [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA391603126 rs1245948944 |
330 | K>E | No |
ClinGen TOPMed |
|
|
rs747242630 CA7462711 |
330 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462714 rs748655667 |
333 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA391603152 rs748655667 |
333 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA391603155 rs1195882263 |
334 | G>W | No |
ClinGen gnomAD |
|
|
CA7462715 rs140949296 |
335 | E>K | No |
ClinGen ESP ExAC TOPMed |
|
|
rs773811120 CA7462716 |
336 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA7462717 rs759117995 |
337 | F>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1270541618 CA391603175 |
337 | F>L | No |
ClinGen gnomAD |
|
|
rs1330925349 CA391603188 |
339 | A>T | No |
ClinGen TOPMed |
|
|
CA7462719 rs775338128 |
342 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs1451429730 CA391603217 |
343 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA7462720 rs760369967 |
343 | E>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs17854161 CA268599867 |
345 | T>I | No |
ClinGen Ensembl |
|
|
rs772800399 CA268599899 |
347 | V>M | No |
ClinGen TOPMed |
|
|
CA391603255 rs1383585565 |
348 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs753645354 CA7462722 |
349 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 349 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201606275 CA7462723 |
351 | T>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA7462724 rs150113487 |
353 | K>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1450437323 CA391603291 |
354 | S>G | No |
ClinGen TOPMed |
|
| rs1233205595 | 354 | S>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7462726 rs138383914 |
355 | D>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs750302868 CA7462725 |
355 | D>H | No |
ClinGen ExAC |
|
|
rs1214012533 CA391603308 COSM960778 |
356 | Y>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs755207183 CA7462729 |
359 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA7462728 rs566576492 |
359 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 360 | N>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA268600039 rs2702304 |
362 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 363 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA268600041 rs199809301 |
364 | S>Y | No |
ClinGen Ensembl |
|
|
CA7462732 rs77994620 |
365 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs770213768 CA7462733 |
366 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778435512 CA7462734 |
367 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA7462735 rs749796523 |
368 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA391603381 rs1281393384 |
369 | H>D | No |
ClinGen TOPMed |
|
|
CA268600082 rs765881650 |
369 | H>P | No |
ClinGen Ensembl |
|
|
rs1567494809 CA391603411 |
373 | S>N | No |
ClinGen Ensembl |
|
| TCGA novel | 374 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7462736 rs149234550 |
377 | V>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA391603442 rs1231117411 |
377 | V>L | No |
ClinGen TOPMed |
|
|
rs143611760 CA268600097 |
379 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs143611760 CA7462737 |
379 | Y>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1161528987 CA391603464 |
380 | K>N | No |
ClinGen gnomAD |
|
|
rs138220644 CA7462739 |
382 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1381925149 CA391603487 |
384 | V>G | No |
ClinGen gnomAD |
|
|
CA7462741 rs376722030 |
385 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs143713868 CA7462742 |
387 | A>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA7462743 rs143713868 |
387 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs147203083 CA7462745 |
389 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 391 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA268600199 rs375883438 |
393 | T>N | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs754976901 CA7462747 |
393 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs141468819 CA268600213 |
395 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA391603561 rs1479606240 |
395 | N>S | No |
ClinGen gnomAD |
|
|
rs1246594524 CA391603558 |
395 | N>Y | No |
ClinGen TOPMed |
|
|
CA268600236 rs75285616 |
397 | C>W | No |
ClinGen Ensembl |
|
|
rs1250967593 CA391603581 |
398 | H>L | No |
ClinGen gnomAD |
|
|
CA391603597 rs1597396438 |
400 | V>G | No |
ClinGen Ensembl |
|
|
CA391603604 rs1349533670 |
401 | K>N | No |
ClinGen gnomAD |
|
|
CA391603615 rs1465544408 |
403 | M>L | No |
ClinGen TOPMed |
|
|
CA391603614 rs1465544408 |
403 | M>V | No |
ClinGen TOPMed |
|
|
rs1171546257 CA391603627 |
404 | P>L | No |
ClinGen gnomAD |
|
|
CA391603624 rs1441376767 |
404 | P>S | No |
ClinGen gnomAD |
|
|
CA7462750 rs756602032 |
406 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs1177548497 CA391603658 |
409 | V>E | No |
ClinGen gnomAD |
|
|
RCV000947608 CA7462751 rs74007678 |
412 | E>K | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs200142699 CA268600237 |
413 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200142699 CA7462752 |
413 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA268600259 rs544489741 |
415 | T>A | No |
ClinGen gnomAD |
|
|
CA7462753 rs193093417 COSM3744559 |
415 | T>M | Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1362918745 CA391603715 |
418 | L>P | No |
ClinGen TOPMed |
|
|
rs1435540126 CA391603736 |
421 | N>K | No |
ClinGen TOPMed |
|
|
rs1597396482 CA391603733 |
421 | N>T | No |
ClinGen Ensembl |
|
|
rs1346655192 CA391603742 |
422 | P>R | No |
ClinGen TOPMed |
|
|
rs1305906753 CA391603740 |
422 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs776403246 CA7462757 |
423 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs747796110 CA7462758 |
427 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462759 rs149897590 |
428 | K>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs772971999 CA7462760 |
429 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772971999 CA391603788 |
429 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762689264 CA7462761 |
429 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1388819762 CA391603794 |
430 | K>T | No |
ClinGen TOPMed |
|
|
rs774093394 CA7462763 |
431 | R>T | No |
ClinGen ExAC gnomAD |
|
|
rs767479515 CA7462765 |
432 | V>G | No |
ClinGen ExAC gnomAD |
|
|
CA7462764 rs759671343 |
432 | V>L | No |
ClinGen ExAC |
|
|
CA7462766 rs753027422 |
435 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA391603821 rs753027422 |
435 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs541846772 CA7462769 |
437 | E>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs756372866 CA391603833 |
437 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA7462767 rs756372866 |
437 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA268600467 rs930066323 |
443 | T>A | No |
ClinGen TOPMed |
|
|
rs146054258 CA7462770 |
443 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1360152982 CA391603879 |
444 | L>V | No |
ClinGen gnomAD |
|
|
CA7462771 rs373677487 |
447 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 448 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 450 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs367796610 CA7462772 |
450 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA268600479 rs1044926847 |
452 | I>F | No |
ClinGen TOPMed |
|
|
rs1468799064 CA391603974 |
458 | Y>* | No |
ClinGen gnomAD |
|
|
rs1223290315 CA391603989 |
460 | I>M | No |
ClinGen gnomAD |
|
|
CA391603996 CA391603998 rs1474879981 |
461 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1239942683 CA391603994 |
461 | M>T | No |
ClinGen gnomAD |
|
|
rs769461692 COSM1580711 CA7462776 |
464 | V>A | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs745879436 CA7462775 |
464 | V>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 466 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA7462778 rs749089359 |
467 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA268600545 rs577587036 |
469 | D>E | No |
ClinGen Ensembl |
|
|
CA7462779 rs770570610 |
470 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs867715071 CA268600573 |
470 | K>M | No |
ClinGen Ensembl |
|
|
rs770570610 CA7462780 |
470 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA391604088 rs1369305999 |
476 | L>P | No |
ClinGen TOPMed |
|
| TCGA novel | 476 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775687892 CA7462783 |
477 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs760785722 CA7462784 |
478 | H>L | No |
ClinGen ExAC gnomAD |
|
|
CA391604100 rs1231371997 |
478 | H>Y | No |
ClinGen gnomAD |
|
|
rs764442245 CA7462785 |
480 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs764442245 CA391604116 |
480 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs1168517029 CA391604157 |
486 | V>I | No |
ClinGen TOPMed |
|
|
rs1410981312 CA391604165 |
487 | N>D | No |
ClinGen TOPMed |
|
|
rs765515490 CA7462788 |
488 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462789 rs750982314 |
492 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA391604221 rs1186621097 |
495 | Y>C | No |
ClinGen gnomAD |
|
|
CA268600659 rs1018487185 |
498 | C>R | No |
ClinGen TOPMed |
|
|
CA391604265 rs1417689718 |
501 | T>I | No |
ClinGen gnomAD |
|
|
CA7462792 rs752238862 |
503 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs1165318205 CA391604285 |
504 | K>N | No |
ClinGen gnomAD |
|
|
rs112012488 CA268600670 |
504 | K>R | No |
ClinGen TOPMed |
|
| TCGA novel | 507 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755558707 CA7462793 |
510 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1400312143 CA391604343 |
513 | R>* | No |
ClinGen gnomAD |
|
|
CA7462794 rs367778274 |
513 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM228175 CA391604352 rs1312353774 |
514 | W>* | Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA391604351 COSM228175 rs1412945989 |
514 | W>* | skin [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA391604347 CA391604346 rs1362521607 |
514 | W>R | No |
ClinGen gnomAD |
|
|
CA391604356 rs1340950180 |
515 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
CA391604355 rs1340950180 |
515 | K>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA7462795 rs748922643 |
516 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778538576 CA7462799 |
518 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771923772 CA7462801 |
519 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA391604408 rs1567495227 |
522 | K>* | No |
ClinGen Ensembl |
|
|
rs775528294 CA7462802 |
522 | K>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA7462803 rs144938376 |
523 | L>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs768844068 CA7462804 |
525 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs777060789 CA7462805 |
526 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs1597396793 CA391604449 |
528 | N>D | No |
ClinGen Ensembl |
|
|
CA7462808 rs750778878 |
528 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA7462807 rs376934994 |
528 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1597396808 CA391604455 |
529 | S>G | No |
ClinGen Ensembl |
|
|
rs1163204283 CA391604457 |
529 | S>N | No |
ClinGen TOPMed |
|
|
CA391604463 rs763340823 |
530 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs763340823 CA7462809 |
530 | K>Q | No |
ClinGen ExAC gnomAD |
No associated diseases with P08912
1 regional properties for P08912
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Olfactomedin-like domain | 230 - 489 | IPR003112 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled acetylcholine receptor activity | Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| G protein-coupled serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by acetylcholine binding to its receptor, and ending with the regulation of a downstream cellular process. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| dopamine transport | The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
| G protein-coupled acetylcholine receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription. |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. |
| gastric acid secretion | The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. |
| regulation of phosphatidylinositol dephosphorylation | Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol. |
| transmission of nerve impulse | The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P30546 | HRH1 | Histamine H1 receptor | Bos taurus (Bovine) | PR |
| P41984 | CHRM3 | Muscarinic acetylcholine receptor M3 | Bos taurus (Bovine) | PR |
| P41985 | CHRM2 | Muscarinic acetylcholine receptor M2 | Bos taurus (Bovine) | PR |
| P17200 | CHRM4 | Muscarinic acetylcholine receptor M4 | Gallus gallus (Chicken) | PR |
| P49578 | CHRM3 | Muscarinic acetylcholine receptor M3 | Gallus gallus (Chicken) | PR |
| P30372 | CHRM2 | Muscarinic acetylcholine receptor M2 | Gallus gallus (Chicken) | PR |
| Q5IS53 | CHRM5 | Muscarinic acetylcholine receptor M5 | Pan troglodytes (Chimpanzee) | PR |
| P08172 | CHRM2 | Muscarinic acetylcholine receptor M2 | Homo sapiens (Human) | PR |
| P08173 | CHRM4 | Muscarinic acetylcholine receptor M4 | Homo sapiens (Human) | PR |
| P20309 | CHRM3 | Muscarinic acetylcholine receptor M3 | Homo sapiens (Human) | PR |
| P35367 | HRH1 | Histamine H1 receptor | Homo sapiens (Human) | PR |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | Homo sapiens (Human) | PR |
| Q9H3N8 | HRH4 | Histamine H4 receptor | Homo sapiens (Human) | PR |
| P11229 | CHRM1 | Muscarinic acetylcholine receptor M1 | Homo sapiens (Human) | PR |
| P70174 | Hrh1 | Histamine H1 receptor | Mus musculus (Mouse) | PR |
| P12657 | Chrm1 | Muscarinic acetylcholine receptor M1 | Mus musculus (Mouse) | PR |
| P32211 | Chrm4 | Muscarinic acetylcholine receptor M4 | Mus musculus (Mouse) | PR |
| Q9ERZ3 | Chrm3 | Muscarinic acetylcholine receptor M3 | Mus musculus (Mouse) | PR |
| Q9ERZ4 | Chrm2 | Muscarinic acetylcholine receptor M2 | Mus musculus (Mouse) | PR |
| Q920H4 | Chrm5 | Muscarinic acetylcholine receptor M5 | Mus musculus (Mouse) | PR |
| P04761 | CHRM1 | Muscarinic acetylcholine receptor M1 | Sus scrofa (Pig) | PR |
| P31390 | Hrh1 | Histamine H1 receptor | Rattus norvegicus (Rat) | PR |
| P08482 | Chrm1 | Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Rat) | PR |
| P08483 | Chrm3 | Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Rat) | PR |
| P08911 | Chrm5 | Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Rat) | PR |
| P56489 | CHRM1 | Muscarinic acetylcholine receptor M1 | Macaca mulatta (Rhesus macaque) | PR |
| P56490 | CHRM5 | Muscarinic acetylcholine receptor M5 | Macaca mulatta (Rhesus macaque) | PR |
| Q9U7D5 | gar-3 | Muscarinic acetylcholine receptor gar-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGDSYHNAT | TVNGTPVNHQ | PLERHRLWEV | ITIAAVTAVV | SLITIVGNVL | VMISFKVNSQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKTVNNYYLL | SLACADLIIG | IFSMNLYTTY | ILMGRWALGS | LACDLWLALD | YVASNASVMN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLVISFDRYF | SITRPLTYRA | KRTPKRAGIM | IGLAWLISFI | LWAPAILCWQ | YLVGKRTVPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DECQIQFLSE | PTITFGTAIA | AFYIPVSVMT | ILYCRIYRET | EKRTKDLADL | QGSDSVTKAE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRKPAHRALF | RSCLRCPRPT | LAQRERNQAS | WSSSRRSTST | TGKPSQATGP | SANWAKAEQL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTCSSYPSSE | DEDKPATDPV | LQVVYKSQGK | ESPGEEFSAE | ETEETFVKAE | TEKSDYDTPN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YLLSPAAAHR | PKSQKCVAYK | FRLVVKADGN | QETNNGCHKV | KIMPCPFPVA | KEPSTKGLNP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NPSHQMTKRK | RVVLVKERKA | AQTLSAILLA | FIITWTPYNI | MVLVSTFCDK | CVPVTLWHLG |
| 490 | 500 | 510 | 520 | 530 | |
| YWLCYVNSTV | NPICYALCNR | TFRKTFKMLL | LCRWKKKKVE | EKLYWQGNSK | LP |