P41811
PR
Gene name |
SEC27 (YGL137W, G2827) |
Protein name |
Coatomer subunit beta' |
Names |
Beta'-coat protein, Beta'-COP |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL137W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
12 structures for P41811
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2YNN | X-ray | 178 A | A | 1-304 | PDB |
| 2YNO | X-ray | 180 A | A/B | 1-304 | PDB |
| 2YNP | X-ray | 296 A | A | 1-604 | PDB |
| 4J73 | X-ray | 144 A | A | 1-301 | PDB |
| 4J77 | X-ray | 176 A | A/B | 1-301 | PDB |
| 4J78 | X-ray | 148 A | A | 1-301 | PDB |
| 4J79 | X-ray | 156 A | A | 1-300 | PDB |
| 4J81 | X-ray | 174 A | A/B | 1-301 | PDB |
| 4J82 | X-ray | 146 A | A/B | 1-301 | PDB |
| 4J84 | X-ray | 147 A | A/B | 1-301 | PDB |
| 4J86 | X-ray | 148 A | A/B | 1-301 | PDB |
| AF-P41811-F1 | Predicted | AlphaFoldDB |
11 variants for P41811
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-250188 | 39 | L>I | No | SGRP | |
| s07-251356 | 428 | W>L | No | SGRP | |
| s07-251355 | 428 | W>R | No | SGRP | |
| s07-251620 | 516 | I>S | No | SGRP | |
| s07-251836 | 588 | A>V | No | SGRP | |
| s07-252174 | 701 | V>I | No | SGRP | |
| s07-252277 | 735 | R>T | No | SGRP | |
| s07-252279 | 736 | A>T | No | SGRP | |
| s07-252411 | 780 | D>N | No | SGRP | |
| s07-252415 | 781 | A>E | No | SGRP | |
| s07-252726 | 885 | V>M | No | SGRP |
No associated diseases with P41811
6 regional properties for P41811
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 2 - 83 | IPR001680-1 |
| repeat | WD40 repeat | 86 - 299 | IPR001680-2 |
| domain | Coatomer, WD associated region | 326 - 776 | IPR006692 |
| repeat | G-protein beta WD-40 repeat | 112 - 126 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 201 - 215 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 243 - 257 | IPR020472-3 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| COPI vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| intracellular mRNA localization | Any process in which mRNA is transported to, or maintained in, a specific location within the cell. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| late endosome to vacuole transport via multivesicular body sorting pathway | The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53622 | COP1 | Coatomer subunit alpha | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P35605 | COPB2 | Coatomer subunit beta' | Bos taurus (Bovine) | PR |
| O62621 | beta'COP | Coatomer subunit beta' | Drosophila melanogaster (Fruit fly) | PR |
| P35606 | COPB2 | Coatomer subunit beta' | Homo sapiens (Human) | PR |
| O55029 | Copb2 | Coatomer subunit beta' | Mus musculus (Mouse) | PR |
| O35142 | Copb2 | Coatomer subunit beta' | Rattus norvegicus (Rat) | PR |
| Q9CAA0 | At1g79990 | Coatomer subunit beta'-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLDIKKTFS | NRSDRVKGID | FHPTEPWVLT | TLYSGRVELW | NYETQVEVRS | IQVTETPVRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GKFIARKNWI | IVGSDDFRIR | VFNYNTGEKV | VDFEAHPDYI | RSIAVHPTKP | YVLSGSDDLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VKLWNWENNW | ALEQTFEGHE | HFVMCVAFNP | KDPSTFASGC | LDRTVKVWSL | GQSTPNFTLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGQERGVNYV | DYYPLPDKPY | MITASDDLTI | KIWDYQTKSC | VATLEGHMSN | VSFAVFHPTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PIIISGSEDG | TLKIWNSSTY | KVEKTLNVGL | ERSWCIATHP | TGRKNYIASG | FDNGFTVLSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GNDEPTLSLD | PVGKLVWSGG | KNAAASDIFT | AVIRGNEEVE | QDEPLSLQTK | ELGSVDVFPQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SLAHSPNGRF | VTVVGDGEYV | IYTALAWRNK | AFGKCQDFVW | GPDSNSYALI | DETGQIKYYK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NFKEVTSWSV | PMHSAIDRLF | SGALLGVKSD | GFVYFFDWDN | GTLVRRIDVN | AKDVIWSDNG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ELVMIVNTNS | NGDEASGYTL | LFNKDAYLEA | ANNGNIDDSE | GVDEAFDVLY | ELSESITSGK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WVGDVFIFTT | ATNRLNYFVG | GKTYNLAHYT | KEMYLLGYLA | RDNKVYLADR | EVHVYGYEIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LEVLEFQTLT | LRGEIEEAIE | NVLPNVEGKD | SLTKIARFLE | GQEYYEEALN | ISPDQDQKFE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LALKVGQLTL | ARDLLTDESA | EMKWRALGDA | SLQRFNFKLA | VEAFTNAHDL | ESLFLLHSSF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NNKEGLVTLA | KDAERAGKFN | LAFNAYWIAG | DIQGAKDLLI | KSQRFSEAAF | LGSTYGLGDD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AVNDIVTKWK | ENLILNGKNT | VSERVCGAEG | LPGSSSSGDA | QPLIDLDSTP | APEQADENKE |
| 850 | 860 | 870 | 880 | ||
| AEVEDSEFKE | SNSEAVEAEK | KEEEAPQQQQ | SEQQPEQGEA | VPEPVEEES |