O35142
Gene name |
Copb2 |
Protein name |
Coatomer subunit beta' |
Names |
Beta'-coat protein, Beta'-COP, p102 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:60384 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35142
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35142-F1 | Predicted | AlphaFoldDB |
No variants for O35142
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O35142 | |||||
No associated diseases with O35142
7 regional properties for O35142
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 4 - 85 | IPR001680-1 |
| repeat | WD40 repeat | 88 - 127 | IPR001680-2 |
| repeat | WD40 repeat | 131 - 266 | IPR001680-3 |
| domain | Coatomer, WD associated region | 319 - 762 | IPR006692 |
| repeat | G-protein beta WD-40 repeat | 158 - 172 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 202 - 216 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 244 - 258 | IPR020472-3 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| COPI vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein kinase C binding | Binding to protein kinase C. |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
| toxin transport | The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41811 | SEC27 | Coatomer subunit beta' | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P35605 | COPB2 | Coatomer subunit beta' | Bos taurus (Bovine) | PR |
| O62621 | beta'COP | Coatomer subunit beta' | Drosophila melanogaster (Fruit fly) | PR |
| P53621 | COPA | Coatomer subunit alpha | Homo sapiens (Human) | PR |
| P35606 | COPB2 | Coatomer subunit beta' | Homo sapiens (Human) | PR |
| O55029 | Copb2 | Coatomer subunit beta' | Mus musculus (Mouse) | PR |
| Q9CAA0 | At1g79990 | Coatomer subunit beta'-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLRLDIKRK | LTAMSDRVKS | VDLHPTEPWM | LASLYNGSVC | VWNHETQTLV | KTFEVCDLPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RAAKFVARKN | WVVTGADDMQ | IRVFNYNTLE | RVHMFEAHSD | YIRCIAVHPT | QPFILTSSDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MLIKLWDWDK | KWSCSQVFEG | HTHYVMQIVI | NPKDNNQFAS | ASLDRTIKVW | QLGSSSPNFT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEGHEKGVNC | IDYYSGGDKP | YLISGADDRL | VKIWDYQNKT | CVQTPEGHAQ | NVSCATFHPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPIIITGSED | GTVRIWHSST | YRLESTLNYG | MERVWCVASL | RGSNNVALGY | DEGSIIVKLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| REEPAMSMDA | NGKIIWAKHS | EVQQANLKAM | GDTEIKDGER | LPLAVKDMGS | CEIYPQTIQH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NPNGRFVVVC | GDGEYIIYTA | MALRNKSFGS | AQEFAWAHDS | SEYAIRESNS | VVKIFKNFKE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KKSFKPDFGA | ESIYGGFLLG | VRSVNGLAFY | DWENTELIRR | IEIQPKHIFW | SDSGELVCIA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TEESFFILKY | LSEKVLAAQE | THEGVTEDGI | EDAFEVLGEI | QEIVKTGLWV | GDCFIYTSSV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NRLNYYVGGE | IVTIAHLDRT | MYLLGYIPKD | NRLYLGDKEL | NIVSYSLLVS | VLEYQTAVMR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RDFSMADKVL | PTIPKEQRTR | VAHFLEKQGF | KQQALTVSTD | PEHRFELALQ | LGELKIAYQL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AVEAESEQKW | KQLAELAISK | CQFSLAQECL | HHAQDYGGLL | LLATASGNAS | MVNKLAEGAE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RDGKNNVAFM | SYFLQGKLDA | CLELLIRTGR | LPEAAFLART | YLPSQVSRVV | KLWRENLSKV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NQKAAESLAD | PTEYENLFPG | LKEAFVVEEW | VKETHADLWP | AKQYPLVTPN | EERNVMEEAK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RFQPSRATAQ | QEPDGKPASS | PVIMASQTTH | KEEKSFQELE | DDLDTMELED | IDTTDINLDE |
| DILDD |