AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-48 (Predicted disordered autoinhibitory region) PR

1-48 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
5A1U	EM	1300 A	D	1-905	PDB
5A1V	EM	2100 A	D/L/U	1-905	PDB
5A1W	EM	1800 A	D	1-905	PDB
5A1X	EM	2300 A	D/L	1-905	PDB
5A1Y	EM	2100 A	D/L	1-905	PDB
5NZR	EM	920 A	C	1-905	PDB
5NZS	EM	1010 A	C	1-905	PDB
5NZT	EM	1700 A	C/H	1-905	PDB
5NZU	EM	1500 A	C	1-905	PDB
5NZV	EM	1730 A	C/J	1-905	PDB
AF-O55029-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389068674	22	D>V	No	EVA
rs3389045375	28	P>Q	No	EVA
rs3389010518	46	T>I	No	EVA
rs3389059086	79	M>L	No	EVA
rs3389045343	98	H>N	No	EVA
rs3389053362	105	I>F	No	EVA
rs3389065106	105	I>M	No	EVA
rs3389063176	116	T>I	No	EVA
rs3389066102	122	L>P	No	EVA
rs3389063141	132	W>R	No	EVA
rs3389073344	136	Q>R	No	EVA
rs3389060515	137	V>M	No	EVA
rs3389066079	147	Q>*	No	EVA
rs3389065930	150	I>L	No	EVA
rs3389053443	171	Q>*	No	EVA
rs3389065102	172	L>R	No	EVA
rs3389073368	205	G>C	No	EVA
rs3389066054	268	N>H	No	EVA
rs3389040470	275	W>G	No	EVA
rs3389040439	328	K>T	No	EVA
rs3389074239	332	D>N	No	EVA
rs3389060565	353	I>L	No	EVA
rs3389068616	365	R>K	No	EVA
rs3389060575	384	R>G	No	EVA
rs3389067489	386	K>*	No	EVA
rs244687417	411	I>V	No	EVA
rs3389073370	433	I>S	No	EVA
rs3389068693	460	R>S	No	EVA
rs3389073365	484	S>L	No	EVA
rs3389066082	487	I>T	No	EVA
rs3389062947	516	V>D	No	EVA
rs3389059145	532	D>G	No	EVA
rs3389066059	540	V>M	No	EVA
rs3400456225	685	L>Q	No	EVA
rs3399993906	687	Q>S	No	EVA
rs3389040478	700	L>P	No	EVA
rs3389074288	703	A>V	No	EVA
rs3389060581	704	T>I	No	EVA
rs3389068653	747	R>T	No	EVA
rs3389060572	779	K>N	No	EVA
rs3389059113	820	P>T	No	EVA
rs3389066080	885	N>D	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	4 - 85	IPR001680-1
repeat	WD40 repeat	88 - 127	IPR001680-2
repeat	WD40 repeat	131 - 266	IPR001680-3
domain	Coatomer, WD associated region	319 - 762	IPR006692
repeat	G-protein beta WD-40 repeat	158 - 172	IPR020472-1
repeat	G-protein beta WD-40 repeat	202 - 216	IPR020472-2
repeat	G-protein beta WD-40 repeat	244 - 258	IPR020472-3

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side	The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
COPI vesicle coat	One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

Name	Definition
protein kinase C binding	Binding to protein kinase C.
structural molecule activity	The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

Name	Definition
endoplasmic reticulum to Golgi vesicle-mediated transport	The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
intra-Golgi vesicle-mediated transport	The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
toxin transport	The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P41811	SEC27	Coatomer subunit beta'	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P35605	COPB2	Coatomer subunit beta'	Bos taurus (Bovine)	PR
O62621	beta'COP	Coatomer subunit beta'	Drosophila melanogaster (Fruit fly)	PR
P53621	COPA	Coatomer subunit alpha	Homo sapiens (Human)	PR
P35606	COPB2	Coatomer subunit beta'	Homo sapiens (Human)	PR
Q8CIE6	Copa	Coatomer subunit alpha	Mus musculus (Mouse)	PR
O35142	Copb2	Coatomer subunit beta'	Rattus norvegicus (Rat)	PR
Q9CAA0	At1g79990	Coatomer subunit beta'-1	Arabidopsis thaliana (Mouse-ear cress)	PR