Q8CIE6

PR
Gene name
Copa
Protein name
Coatomer subunit alpha
Names
Alpha-coat protein, Alpha-COP
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12847
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

793-874 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for Q8CIE6

Entry ID Method Resolution Chain Position Source
5A1U EM 1300 A C 1-1224 PDB
5A1V EM 2100 A C/K/T 1-1224 PDB
5A1W EM 1800 A C 1-1224 PDB
5A1X EM 2300 A C/K 1-1224 PDB
5A1Y EM 2100 A C/K 1-1224 PDB
5NZR EM 920 A A 1-1224 PDB
5NZS EM 1010 A A 1-1224 PDB
5NZT EM 1700 A A 1-1224 PDB
5NZU EM 1500 A A 1-1224 PDB
5NZV EM 1730 A A/H 1-1224 PDB
AF-Q8CIE6-F1 Predicted AlphaFoldDB

61 variants for Q8CIE6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388514044 24 I>V No EVA
rs3388517514 96 I>F No EVA
rs3388516689 97 R>P No EVA
rs3388515851 100 F>Y No EVA
rs3388518867 125 R>G No EVA
rs3388518888 158 T>I No EVA
rs3388516356 177 V>M No EVA
rs3388517530 185 T>P No EVA
rs3388516578 195 A>P No EVA
rs3388513979 204 H>L No EVA
rs3388516631 208 V>L No EVA
rs3390906096 219 L>H No EVA
rs3390990225 221 V>E No EVA
rs3391023212 221 V>L No EVA
rs3391003228 222 S>Y No EVA
rs3391005190 225 D>* No EVA
rs3390977330 257 F>I No EVA
rs3388517505 327 A>V No EVA
rs3388517178 345 D>E No EVA
rs3388517524 351 D>V No EVA
rs3391003204 355 M>I No EVA
rs3388515233 370 Y>C No EVA
rs3388515232 392 D>E No EVA
rs3388513413 412 R>P No EVA
rs3388517576 416 L>M No EVA
rs3413051744 430 D>E No EVA
rs3388513767 439 N>S No EVA
rs3388516720 508 K>* No EVA
rs3388514238 522 C>S No EVA
rs3388511914 553 V>I No EVA
rs3388513392 618 A>T No EVA
rs3388514191 634 Y>C No EVA
rs3388516691 638 A>T No EVA
rs3388515777 641 F>L No EVA
rs3412841302 691 E>K No EVA
rs3388515831 709 I>N No EVA
rs3388517525 714 E>D No EVA
rs3388515276 732 H>L No EVA
rs3388515288 747 R>W No EVA
rs46240705 761 S>T No EVA
rs3391005217 763 A>S No EVA
rs3390987297 764 T>S No EVA
rs3388511890 806 T>I No EVA
rs3388518928 820 G>R No EVA
rs3388516418 865 L>V No EVA
rs3388515272 902 A>V No EVA
rs3388516248 908 V>E No EVA
rs3388518861 960 L>I No EVA
rs3388511875 968 T>S No EVA
rs3388516931 983 P>A No EVA
rs3388517181 983 P>L No EVA
rs13461811 984 N>S No EVA
rs13461815 999 V>I No EVA
rs3391005258 1013 C>W No EVA
rs3390990222 1042 D>H No EVA
rs3388515256 1054 I>T No EVA
rs3388515258 1067 E>G No EVA
rs13461818 1072 K>N No EVA
rs3388516601 1111 L>P No EVA
rs3388514149 1127 R>H No EVA
rs3388517169 1195 E>A No EVA

No associated diseases with Q8CIE6

11 regional properties for Q8CIE6

Type Name Position InterPro Accession
repeat WD40 repeat 2 - 39 IPR001680-1
repeat WD40 repeat 40 - 165 IPR001680-2
repeat WD40 repeat 194 - 318 IPR001680-3
domain Coatomer, WD associated region 343 - 766 IPR006692
domain Coatomer, alpha subunit, C-terminal 815 - 1224 IPR010714
conserved_site WD40 repeat, conserved site 150 - 164 IPR019775
repeat G-protein beta WD-40 repeat 108 - 122 IPR020472-1
repeat G-protein beta WD-40 repeat 150 - 164 IPR020472-2
repeat G-protein beta WD-40 repeat 264 - 278 IPR020472-3
domain Anaphase-promoting complex subunit 4-like, WD40 domain 212 - 291 IPR024977
domain Coatomer subunit alpha, WD Associated Region 324 - 774 IPR047312

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.
COPI-coated vesicle A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

3 GO annotations of molecular function

Name Definition
hormone activity The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

7 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
pancreatic juice secretion The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.
protein localization to axon A process in which a protein is transported to or maintained in a location within an axon.
protein localization to cell leading edge A process in which a protein is transported to, or maintained in, a location within a cell leading edge.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53622 COP1 Coatomer subunit alpha Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P53621 COPA Coatomer subunit alpha Homo sapiens (Human) PR
O55029 Copb2 Coatomer subunit beta' Mus musculus (Mouse) PR
10 20 30 40 50 60
MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH
70 80 90 100 110 120
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW
130 140 150 160 170 180
NWQSRTCVCV LTGHNHYVMC AQFHPSEDLV VSASLDQTVR VWDISGLRKK NLSPGAVESD
190 200 210 220 230 240
VRGITGVDLF GTTDAVVKHV LEGHDRGVNW AAFHPTMPLI VSGADDRQVK IWRMNESKAW
250 260 270 280 290 300
EVDTCRGHYN NVSCAVFHPR QELILSNSED KSIRVWDMSK RTGVQTFRRD HDRFWVLAAH
310 320 330 340 350 360
PNLNLFAAGH DGGMIVFKLE RERPAYAVHG NMLHYVKDRF LRQLDFNSSK DVAVMQLRSG
370 380 390 400 410 420
SKFPVFNMSY NPAENAVLLC TRASNLENST YDLYTIPKDA DSQNPDAPEG KRSSGLTAVW
430 440 450 460 470 480
VARNRFAVLD RMHSLLIKNL KNEITKKIQV PNCDEIFYAG TGNLLLRDAD SITLFDVQQK
490 500 510 520 530 540
RTLASVKISK VKYVIWSADM SHVALLAKHA IVICNRKLDA LCNIHENIRV KSGAWDESGV
550 560 570 580 590 600
FIYTTSNHIK YAVTTGDHGI IRTLDLPIYV TRVKGNNVYC LDRECRPRVL TIDPTEFKFK
610 620 630 640 650 660
LALINRKYDE VLHMVRNAKL VGQSIIAYLQ KKGYPEVALH FVKDEKTRFS LALECGNIEI
670 680 690 700 710 720
ALEAAKALDD KNCWEKLGEV ALLQGNHQIV EMCYQRTKNF DKLSFLYLIT GNLEKLRKMM
730 740 750 760 770 780
KIAEIRKDMS GHYQNALYLG DVSERVRILK NCGQKSLAYL SAATHGLDEE AESLKETFDP
790 800 810 820 830 840
EKETIPDIDP NAKLLQPPAP IMPLDTNWPL LTVSKGFFEG SIASKGKGGA LAADIDIDTV
850 860 870 880 890 900
GTEGWGEDAE LQLDEDGFVE APEGLGEDVL GKGQEEGGGW DVEEDLELPP ELDVPSGVSG
910 920 930 940 950 960
SAEDGFFVPP TKGTSPTQIW CNNSQLPVDH ILAGSFETAM RLLHDQVGVI QFGPYKQLFL
970 980 990 1000 1010 1020
QTYARGRTTY QALPCLPSMY SYPNRNWKDA GLKNGVPAVG LKLNDLIQRL QLCYQLTTVG
1030 1040 1050 1060 1070 1080
KFEEAVEKFR SILLSVPLLV VDNKQEIAEA QQLITICREY IVGLCMEIER KKLPKETLDQ
1090 1100 1110 1120 1130 1140
QKRICEMAAY FTHSNLQPVH MILVLRTALN LFFKLKNFKT AATFARRLLE LGPKPEVAQQ
1150 1160 1170 1180 1190 1200
TRKILSACEK NPTDACQLNY DMHNPFDICA ASYRPIYRGK PVEKCPLSGA CYSPEFKGQI
1210 1220
CRVTTVTEIG KDVIGLRISP LQFR