P53622

PR
Gene name
COP1 (RET1, SEC33, SOO1, YDL145C, D1578)
Protein name
Coatomer subunit alpha
Names
Alpha-coat protein, Alpha-COP, Retrieval from endoplasmic reticulum protein 1, Secretory protein 22, Suppressor of osmo-sensitivity 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDL145C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

751-924 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P53622

Entry ID Method Resolution Chain Position Source
3MKQ X-ray 250 A B/D/F 642-818 PDB
3MV2 X-ray 290 A A/C/E 900-1201 PDB
3MV3 X-ray 325 A A/C/E 900-1201 PDB
6U3W X-ray 239 A A 899-1201 PDB
AF-P53622-F1 Predicted AlphaFoldDB

15 variants for P53622

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-197042 379 N>S No SGRP
s04-196791 463 A>S No SGRP
s04-196773 469 L>V No SGRP
s04-196187 664 V>A No SGRP
s04-196151 676 S>I No SGRP
s04-195921 753 F>L No SGRP
s04-195669 837 D>N No SGRP
s04-195648 844 N>D No SGRP
s04-195464 905 I>T No SGRP
s04-195243 979 Q>K No SGRP
s04-195161 1006 P>L No SGRP
s04-195123 1019 R>C No SGRP
s04-195099 1027 D>N No SGRP
s04-195096 1028 A>T No SGRP
s04-194657 1174 V>A No SGRP

No associated diseases with P53622

11 regional properties for P53622

Type Name Position InterPro Accession
repeat WD40 repeat 4 - 39 IPR001680-1
repeat WD40 repeat 42 - 174 IPR001680-2
repeat WD40 repeat 198 - 322 IPR001680-3
domain Coatomer, WD associated region 343 - 770 IPR006692
domain Coatomer, alpha subunit, C-terminal 829 - 1199 IPR010714
conserved_site WD40 repeat, conserved site 152 - 166 IPR019775-1
conserved_site WD40 repeat, conserved site 268 - 282 IPR019775-2
repeat G-protein beta WD-40 repeat 110 - 124 IPR020472-1
repeat G-protein beta WD-40 repeat 152 - 166 IPR020472-2
repeat G-protein beta WD-40 repeat 268 - 282 IPR020472-3
domain Coatomer subunit alpha, WD Associated Region 328 - 777 IPR047312

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side
  • Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side
  • The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

2 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

5 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular mRNA localization Any process in which mRNA is transported to, or maintained in, a specific location within the cell.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41811 SEC27 Coatomer subunit beta' Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P53621 COPA Coatomer subunit alpha Homo sapiens (Human) PR
Q8CIE6 Copa Coatomer subunit alpha Mus musculus (Mouse) PR
10 20 30 40 50 60
MKMLTKFESK STRAKGIAFH PSRPWVLVAL FSSTIQLWDY RMGTLLHRFE DHEGPVRGLD
70 80 90 100 110 120
FHPTQPIFVS AGDDYTIKVW SLDTNKCLYT LTGHLDYVRT VFFHRELPWI ISASDDQTIR
130 140 150 160 170 180
IWNWQNRKEI ACLTGHNHFV MCAQFHPTDD LIVSASLDET IRIWDISGLR KRHSAPGTSS
190 200 210 220 230 240
FEEQMSAQQN LLDGSLGDCV VKFILEGHTR GVNWASFHPT LPLIVSGSDD RQVKLWRMSA
250 260 270 280 290 300
TKAWEVDTCR GHTNNVDSVI FHPHQNLIIS VGEDKTLRVW DLDKRTPVKQ FKRENDRFWL
310 320 330 340 350 360
IAAHPHINLF GAAHDSGIMV FKLDRERPCS FIHQNQLFFV NAEKQIQSFN FQKRVASLPY
370 380 390 400 410 420
ASLKGIGQPW DAFRSISYNP SQHSVLVNEA NGKFALVILP KQPVGAVEPT SVTQDTGNFA
430 440 450 460 470 480
TFVGRNRFVV YNKNTESVEV RSLENKVTRN IKVEETVRTI VAAGPGSVLV IHPREVILYD
490 500 510 520 530 540
VQQGKKVSQL AVKNVKYVSW SLDGQYVALM SKHTITLATK KLELINSMHE TIRIKSAAWD
550 560 570 580 590 600
ETGVLIYSTL NHIRYSLLNG DRGIIKTLEK TLYITKVQGK LVYCLNREGE IEILTIDPTE
610 620 630 640 650 660
YRFKKALVNK NFPEVLRLIK DSNLVGQNII SYLQKSGYPE IALQFVQDPH IRFDLALEYG
670 680 690 700 710 720
NLDVALDEAK KLNDSSTWER LIQEALAQGN ASLAEMIYQT QHSFDKLSFL YLVTGDVNKL
730 740 750 760 770 780
SKMQNIAQTR EDFGSMLLNT FYNNSTKERS SIFAEGGSLP LAYAVAKANG DEAAASAFLE
790 800 810 820 830 840
QAEVDEQDVT LPDQMDASNF VQRPVISKPL EKWPLKEAEL SYFEKAVLGQ IDDLTIDDET
850 860 870 880 890 900
PAVNTTQEQE EPLGEENFND EDIGEDEGAW DLGDEDLDVG EELPEEVEQG EITSPAQEVE
910 920 930 940 950 960
TAIWIKNSKL PAVLVAAGAF DAAVQALSKQ VGVVKLEPLK KYFTNIYEGC RTYIPSTPCE
970 980 990 1000 1010 1020
LPAQLGYVRA YDDTVSEDQI LPYVPGLDVV NEKMNEGYKN FKLNKPDIAI ECFREAIYRI
1030 1040 1050 1060 1070 1080
TLLMVDDAED EKLAHKILET AREYILGLSI ELERRSLKEG NTVRMLELAA YFTKAKLSPI
1090 1100 1110 1120 1130 1140
HRTNALQVAM SQHFKHKNFL QASYFAGEFL KIISSGPRAE QARKIKNKAD SMASDAIPID
1150 1160 1170 1180 1190 1200
FDPYAKFDIC AATYKPIYED TPSVSDPLTG SKYVITEKDK IDRIAMISKI GAPASGLRIR
V