O62621
Gene name |
beta'COP |
Protein name |
Coatomer subunit beta' |
Names |
Beta'-coat protein, Beta'-COP |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG6699 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O62621
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O62621-F1 | Predicted | AlphaFoldDB |
No variants for O62621
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O62621 | |||||
No associated diseases with O62621
9 regional properties for O62621
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 4 - 43 | IPR001680-1 |
| repeat | WD40 repeat | 46 - 85 | IPR001680-2 |
| repeat | WD40 repeat | 88 - 127 | IPR001680-3 |
| repeat | WD40 repeat | 131 - 172 | IPR001680-4 |
| repeat | WD40 repeat | 174 - 257 | IPR001680-5 |
| domain | Coatomer, WD associated region | 320 - 764 | IPR006692 |
| repeat | G-protein beta WD-40 repeat | 158 - 172 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 202 - 216 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 244 - 258 | IPR020472-3 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| COPI vesicle coat | One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi stack | The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| regulation of lipid storage | Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41811 | SEC27 | Coatomer subunit beta' | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P35605 | COPB2 | Coatomer subunit beta' | Bos taurus (Bovine) | PR |
| P53621 | COPA | Coatomer subunit alpha | Homo sapiens (Human) | PR |
| P35606 | COPB2 | Coatomer subunit beta' | Homo sapiens (Human) | PR |
| O55029 | Copb2 | Coatomer subunit beta' | Mus musculus (Mouse) | PR |
| O35142 | Copb2 | Coatomer subunit beta' | Rattus norvegicus (Rat) | PR |
| Q9CAA0 | At1g79990 | Coatomer subunit beta'-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLKLDIKRR | LTSRSDRVKC | VDLHPAEPWM | LCALYNGHVH | IMNYENQQMV | KDFEVCDVPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSARFVARKN | WILTGSDDMQ | IRVFNYNTLE | KVHSFEAHSD | YLRCIAVHPT | QPLVLTSSDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MLIKLWNWEK | MWACQRVFEG | HTHYVMQIVF | NPKDNNTFAS | ASLDRTVKVW | QLGSNFANFT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEGHEKGVNC | VDYYHGGDKP | YLISGADDRL | VKIWDYQNKT | CVQTLEGHAQ | NISAVCFHPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPIVLTGSED | GTVRIWHSGT | YRLETCLNYG | FERVWTISSM | RGTNNVALGY | DEGSIIIKVG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| REEPAMSMDV | VGSKIIWAKH | SEMQQVNLKT | IADGTEIKDG | ERLPVATKDM | GACEIYPQTI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AHNPNGRFVV | VCGDGEYIIY | TSMALRNKAF | GSAQEFVWAL | ESNEYAIREN | NGTVRLFRNF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KERKSFTPEY | GAESIYGGYY | FGVKTSSGLA | FYDWETLQLV | RRIEVQPKNV | FWNESGSLVC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LATDDSYFVL | GVDTAQVANA | VETKEGLEDD | GVESAFNVLG | EVSECVKTGL | WVGDCFIYTN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SVNRINYYVG | GEIVTVSHLD | RTMYLLGYVP | KDNRIYLGDK | ELNVISFCLQ | LSVLEYQTAV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MRRDFERADV | VLPTIPKEHR | TRVAHFLEKQ | GFKSQALQVS | TDADHKFDLA | LQIGDLEIAL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KLARESENSQ | KWSQLADVAS | SKNNMSLVKE | CMQKANDLSG | LLLLSTASGD | AQLLEVVGAA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GSAQGHHNLA | FLSAFLRSDV | ERCLEILIET | NRLPEAAFFA | RTYLPSQMSR | IVELWREKLG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KVNEKAGQSL | ADPAQYTNLF | PGLGDALRVE | QHLQEERARK | APARLAANLP | LNSERHPLQE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LFAAEQGAAG | QHLEEKVKPA | YVPAQAVVSS | SQVAEPTSAA | DDDDDLDLEI | DGITLDDNID |
| 910 | |||||
| TTDVNLDDDF | LSDD |