Q9CAA0

PR
Gene name
At1g79990 (F18B13.7, F19K16.4)
Protein name
Coatomer subunit beta'-1
Names
Beta'-coat protein 1, Beta'-COP 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G79990
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

780-920 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9CAA0

Entry ID Method Resolution Chain Position Source
AF-Q9CAA0-F1 Predicted AlphaFoldDB

47 variants for Q9CAA0

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_30086196_G_A 4 R>K No 1000Genomes
ENSVATH05177089 27 E>D No 1000Genomes
ENSVATH05177091 39 L>M No 1000Genomes
tmp_1_30086477_A_T 44 Y>F No 1000Genomes
ENSVATH00150758 69 K>R No 1000Genomes
tmp_1_30086747_G_T 73 V>L No 1000Genomes
ENSVATH05177095 106 A>S No 1000Genomes
ENSVATH05177096 107 V>G No 1000Genomes
tmp_1_30086858_A_G 110 T>A No 1000Genomes
ENSVATH13842101 161 A>V No 1000Genomes
ENSVATH13842103 202 L>I No 1000Genomes
ENSVATH13842105 224 T>S No 1000Genomes
tmp_1_30087554_C_T 258 A>V No 1000Genomes
ENSVATH00150759 259 T>A No 1000Genomes
tmp_1_30087736_A_G 281 K>R No 1000Genomes
ENSVATH13842125 424 V>M No 1000Genomes
tmp_1_30089154_G_A 480 A>T No 1000Genomes
ENSVATH13842128 498 Y>C No 1000Genomes
tmp_1_30089407_C_T 523 R>C No 1000Genomes
tmp_1_30089851_A_G 615 K>E No 1000Genomes
ENSVATH13842135 621 V>M No 1000Genomes
tmp_1_30090103_G_T 646 E>D No 1000Genomes
ENSVATH00150766 659 D>G No 1000Genomes
tmp_1_30090408_G_A 686 A>T No 1000Genomes
tmp_1_30090424_G_C 691 R>T No 1000Genomes
ENSVATH00150767 692 H>D No 1000Genomes
ENSVATH00150768 746 V>M No 1000Genomes
tmp_1_30090707_C_T 758 A>V No 1000Genomes
ENSVATH05177133 780 I>L No 1000Genomes
tmp_1_30090901_C_T 789 A>V No 1000Genomes
ENSVATH05177134 795 P>S No 1000Genomes
tmp_1_30090951_T_A 806 S>T No 1000Genomes
tmp_1_30090952_C_A 806 S>Y No 1000Genomes
tmp_1_30090964_G_A 810 R>K No 1000Genomes
tmp_1_30091225_T_C 817 V>A No 1000Genomes
ENSVATH00150770 828 A>V No 1000Genomes
tmp_1_30091271_T_G 832 H>Q No 1000Genomes
ENSVATH05177141 838 A>G No 1000Genomes
ENSVATH05177142 844 I>R No 1000Genomes
tmp_1_30091321_G_A 849 R>Q No 1000Genomes
tmp_1_30091324_T_C 850 L>P No 1000Genomes
tmp_1_30091575_G_C 889 E>D No 1000Genomes
ENSVATH05177143 890 A>G No 1000Genomes
ENSVATH00150771 895 A>T No 1000Genomes
ENSVATH05177144 899 D>E No 1000Genomes
ENSVATH13842145 907 N>T No 1000Genomes
tmp_1_30091633_T_A 909 S>T No 1000Genomes

No associated diseases with Q9CAA0

8 regional properties for Q9CAA0

Type Name Position InterPro Accession
repeat WD40 repeat 4 - 43 IPR001680-1
repeat WD40 repeat 46 - 85 IPR001680-2
repeat WD40 repeat 88 - 127 IPR001680-3
repeat WD40 repeat 131 - 266 IPR001680-4
domain Coatomer, WD associated region 319 - 762 IPR006692
repeat G-protein beta WD-40 repeat 158 - 172 IPR020472-1
repeat G-protein beta WD-40 repeat 202 - 216 IPR020472-2
repeat G-protein beta WD-40 repeat 244 - 258 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

4 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41811 SEC27 Coatomer subunit beta' Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P35605 COPB2 Coatomer subunit beta' Bos taurus (Bovine) PR
O62621 beta'COP Coatomer subunit beta' Drosophila melanogaster (Fruit fly) PR
P35606 COPB2 Coatomer subunit beta' Homo sapiens (Human) PR
O55029 Copb2 Coatomer subunit beta' Mus musculus (Mouse) PR
O35142 Copb2 Coatomer subunit beta' Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPLRLEIKRK FAQRSERVKS VDLHPTEPWI LASLYSGTLC IWNYQTQTMV KSFDVTELPV
70 80 90 100 110 120
RSAKFIARKQ WVVAGADDMF IRVYNYNTMD KIKVFEAHAD YIRCVAVHPT LPYVLSSSDD
130 140 150 160 170 180
MLIKLWDWEK GWLCTQIFEG HSHYVMQVTF NPKDTNTFAS ASLDRTIKIW NLGSPDPNFT
190 200 210 220 230 240
LDAHLKGVNC VDYFTGGDKP YLITGSDDHT AKVWDYQTKS CVQTLEGHTH NVSAVSFHPE
250 260 270 280 290 300
LPIIITGSED GTVRIWHATT YRLENTLNYG LERVWAIGHI KGSRRVVIGY DEGSIMVKLG
310 320 330 340 350 360
REIPVASMDN SGKIIWAKHN EIHTVNIKSV GADEVTDGER LPLAVKELGT CDLYPQSLKH
370 380 390 400 410 420
NPNGRFVVVC GDGEYIIYTA LAWRNRSFGS ALEFVWSSDG EHAVRESSTK IKIFSKNFQE
430 440 450 460 470 480
KKTVRPTFSA EHIFGGTLLT MCSSDFICFY DWAECRLIRR IDVTVKNLYW ADSGDLVAIA
490 500 510 520 530 540
SDTSFYILKF NRDIVSSYFD GGKQIDEEGI EDAFELLNET NERVRTGLWV GDCFIYTNSS
550 560 570 580 590 600
WRLNYCVGGE VTTMYHLDRP MYLLGYLANQ SRVYLIDKEF NVIGYTLLLS LIEYKTLVMR
610 620 630 640 650 660
GDLEQANEVL PSIPKEHHNS VAHFLESRGM TEDALEVATD PDYRFELAIQ LGRLAVAKDI
670 680 690 700 710 720
AVEAQNESKW KQLGELAMSS GKLDMAEECM RHAMDLSGLL LLYSSLGDAD GMMKLAALAK
730 740 750 760 770 780
EQGKNNVAFL CLFMLGQVED CLHLLVESNR IPEAALMARS YLPSKVSEIV ALWRNDLTKI
790 800 810 820 830 840
SPKAAESLAD PEEYPNLFEE WQVALSLENR AAETRGVHPP AGDYCSHADR DHTTLVDAFR
850 860 870 880 890 900
IMQIEEEGRL EQGDVLDEVG EEGEDGEEEE EEDRQEESSD GRQQNVEEEA VVVDADSTDG
910
AVLVNGNESE EQWVLTPPQE