P32604

PR
Gene name
FBP26
Protein name
Fructose-2,6-bisphosphatase
Names
FBPase 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJL155C
EC number
3.1.3.46: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

394-452 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P32604

Entry ID Method Resolution Chain Position Source
AF-P32604-F1 Predicted AlphaFoldDB

7 variants for P32604

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-130477 55 D>G No SGRP
s10-130422 73 D>E No SGRP
s10-130235 136 D>N No SGRP
s10-130171 157 S>F No SGRP
s10-130076 189 T>A No SGRP
s10-129830 271 I>V No SGRP
s10-129290 451 K>Q No SGRP

No associated diseases with P32604

19 regional properties for P32604

Type Name Position InterPro Accession
domain MaoC-like dehydratase domain 1523 - 1647 IPR002539
domain Fatty acid synthase 581 - 601 IPR003965-1
domain Fatty acid synthase 607 - 625 IPR003965-2
domain Fatty acid synthase 706 - 724 IPR003965-3
domain Fatty acid synthase 726 - 745 IPR003965-4
domain Fatty acid synthase 913 - 931 IPR003965-5
domain Fatty acid synthase 1012 - 1036 IPR003965-6
domain Fatty acid synthase 1547 - 1569 IPR003965-7
domain Fatty acid synthase 1569 - 1590 IPR003965-8
domain Fatty acid synthase 1654 - 1673 IPR003965-9
domain Fatty acid synthase 1675 - 1698 IPR003965-10
domain Fatty acid synthase 1796 - 1815 IPR003965-11
domain Fatty acid synthase 1832 - 1853 IPR003965-12
domain Fatty acid synthase beta subunit AflB /Fas1-like, central domain 727 - 1074 IPR013565
domain Acyl transferase 1663 - 2037 IPR014043
domain Starter unit:ACP transacylase 159 - 412 IPR032088
domain N-terminal of MaoC-like dehydratase 1285 - 1405 IPR039569
domain Fatty acid synthase, meander beta sheet domain 1134 - 1272 IPR040883
domain Fatty acid synthase subunit beta, N-terminal domain 5 - 131 IPR041099

Functions

Description
EC Number 3.1.3.46 Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
6-phosphofructo-2-kinase activity Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fructose-2,6-bisphosphate 2-phosphatase activity Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.

3 GO annotations of biological process

Name Definition
fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P40433 PFK26 6-phosphofructo-2-kinase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P26285 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Bos taurus (Bovine) PR
P49872 PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Bos taurus (Bovine) PR
O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Homo sapiens (Human) PR
P16118 PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Homo sapiens (Human) PR
Q16877 PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Homo sapiens (Human) PR
Q16875 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Homo sapiens (Human) PR
P70265 Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Mus musculus (Mouse) PR
P70266 Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Mus musculus (Mouse) PR
Q6DTY7 Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Mus musculus (Mouse) PR
Q9JJH5 Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Rattus norvegicus (Rat) PR
P07953 Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Rattus norvegicus (Rat) PR
P25114 Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Rattus norvegicus (Rat) PR
O35552 Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGYSTISNDN DIKVCVIMVG LPARGKSFIS QKIIRYLSWL SIKAKCFNVG NYRRDVSGNV
70 80 90 100 110 120
PMDAEFFNFE NTDNFKLREL AAQNAIKDIV NFFTKEDGSV AVFDATNSTR KRRKWLKDIC
130 140 150 160 170 180
EKNNIQPMFL ESWSNDHELI INNAKDIGST SPDYENSEPH VAEADFLERI RQYERFYEPL
190 200 210 220 230 240
DPQKDKDMTF IKLVNIIEEV VINKIRTYLE SRIVFYVMNI RPKPKYIWLS RHGESIYNVE
250 260 270 280 290 300
KKIGGDSSLS ERGFQYAKKL EQLVKESAGE INLTVWTSTL KRTQQTANYL PYKKLQWKAL
310 320 330 340 350 360
DELDAGVCDG MTYEEIEKEY PEDFKARDND KYEYRYRGGE SYRDVVIRLE PVIMELERQE
370 380 390 400 410 420
NVLIITHQAV LRCIYAYFMN VPQEESPWMS IPLHTLIKLE PRAYGTKVTK IKANIPAVST
430 440 450
YKEKGTSQVG ELSQSSTKLH QLLNDSPLED KF