O35552
Gene name |
Pfkfb3 |
Protein name |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
Names |
6PF-2-K/Fru-2,6-P2ase 3, PFK/FBPase 3, 6PF-2-K/Fru-2,6-P2ase brain-type isozyme, RB2K |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:117276 |
EC number |
2.7.1.105: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35552
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35552-F1 | Predicted | AlphaFoldDB |
1 variants for O35552
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8174945 | 185 | D>H | No | EVA |
No associated diseases with O35552
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.105 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 6-phosphofructo-2-kinase activity | Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| fructose-2,6-bisphosphate 2-phosphatase activity | Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| fructose 2,6-bisphosphate metabolic process | The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. |
| fructose metabolic process | The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. |
| regulation of glycolytic process | Any process that modulates the frequency, rate or extent of glycolysis. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32604 | FBP26 | Fructose-2,6-bisphosphatase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P49872 | PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 | Bos taurus (Bovine) | PR |
| P26285 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 | Bos taurus (Bovine) | PR |
| O60825 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 | Homo sapiens (Human) | PR |
| P16118 | PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 | Homo sapiens (Human) | PR |
| Q16877 | PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | Homo sapiens (Human) | PR |
| Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | Homo sapiens (Human) | PR |
| P70265 | Pfkfb2 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 | Mus musculus (Mouse) | PR |
| P70266 | Pfkfb1 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 | Mus musculus (Mouse) | PR |
| Q6DTY7 | Pfkfb4 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | Mus musculus (Mouse) | PR |
| Q9JJH5 | Pfkfb2 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 | Rattus norvegicus (Rat) | PR |
| P07953 | Pfkfb1 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 | Rattus norvegicus (Rat) | PR |
| P25114 | Pfkfb4 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLELTQSRV | QKIWVPVDHR | PSLPRSCGPK | LTNSPTVIVM | VGLPARGKTY | ISKKLTRYLN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WIGVPTKVFN | VGEYRREAVK | QYSSYNFFRP | DNEEAMRVRK | QCALAALRDV | KSYLTKEGGQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IAVFDATNTT | RERRHMILHF | AKENDFKAFF | IESVCDDPTV | VASNIMEVKI | SSPDYKDCNS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AEAMDDFMKR | INCYEASYQP | LDPDKCDRDL | SFIKVIDVGR | RFLVNRVQDH | IQSRIVYYLM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NIHVQPRTIY | LCRHGENEYN | VQGKIGGDSG | LSSRGKKFAN | ALSKFVEEQN | LKDLRVWTSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKSTIQTAEA | LRLPYEQWKA | LNEIDAGVCE | ELTYEEIRDT | YPEEYALREQ | DKYYYRYPTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ESYQDLVQRL | EPVIMELERQ | ENVLVICHQA | VLRCLLAYFL | DKSAEEMPYL | KCPLHTVLKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TPVAYGCRVE | SIYLNVESVS | THRERSEAVK | IQHFASVVRP | SSYTELDFLS | VESAKQDAKK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GPNPLMRRNS | VTPLASPEPT | KKPRINSFEE | HVASTSAALP | SCLPPEVPTQ | LPGQPLLGKA |
| 550 | |||||
| CLRTVCHIFS | KFSPY |