P26285

PR
Gene name
PFKFB2
Protein name
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Names
6PF-2-K/Fru-2,6-P2ase 2, PFK/FBPase 2, 6PF-2-K/Fru-2,6-P2ase heart-type isozyme
Species
Bos taurus (Bovine)
KEGG Pathway
bta:287019
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

427-531 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P26285

Entry ID Method Resolution Chain Position Source
5HR5 X-ray 182 A A 1-531 PDB
AF-P26285-F1 Predicted AlphaFoldDB

78 variants for P26285

Variant ID(s) Position Change Description Diseaes Association Provenance
rs458894787 14 N>D No EVA
rs133157344 24 I>M No EVA
rs460118649 31 W>S No EVA
rs470609723 54 Y>H No EVA
rs523725610 55 V>M No EVA
rs439120701 71 K>Q No EVA
rs460717933 79 R>Q No EVA
rs444708948 83 V>G No EVA
rs441142542 106 C>F No EVA
rs472612536 106 C>R No EVA
rs458075664 107 A>T No EVA
rs470434151 127 V>G No EVA
rs435656602 128 F>C No EVA
rs446441053 135 R>* No EVA
rs472579652 139 D>E No EVA
rs436116841 171 E>D No EVA
rs452970964 172 V>L No EVA
rs137338849 208 D>A No EVA
rs523758851 225 R>I* No EVA
rs469765673 273 S>L No EVA
rs452861961 285 A>S No EVA
rs473148541 297 D>A No EVA
rs451894448 302 T>R No EVA
rs452056795 321 Q>E No EVA
rs475125428 367 Y>F No EVA
rs440526716 396 M>I No EVA
rs454024923 400 L>P No EVA
rs439519754 408 A>V No EVA
rs474378677 443 V>L No EVA
rs454105443 455 P>A No EVA
rs433005270 473 S>R No EVA
rs456430172 477 I>T No EVA
rs476377251 479 R>G No EVA
rs441820264 479 R>L No EVA
rs455484190 483 Y>* No EVA
rs440914983 487 S>I No EVA
rs440914983 487 S>T No EVA
rs477615756 489 P>T No EVA
rs439816614 490 L>P No EVA
rs135008912 491 Q>P No EVA
rs463286985 492 P>H No EVA
rs483241669 493 L>R No EVA
rs448653654 494 S>R No EVA
rs468780639 494 S>T No EVA
rs447788408 496 L>P No EVA
rs464508665 498 A>P No EVA
rs464508665 498 A>T No EVA
rs433173458 499 L>P No EVA
rs456403545 501 T>S No EVA
rs435517274 505 A>S No EVA
rs472428987 506 D>A No EVA
rs472428987 506 D>G No EVA
rs472428987 506 D>V No EVA
rs440820979 507 Q>* No EVA
rs452446326 512 A>P No EVA
rs452446326 512 A>S No EVA
rs452446326 512 A>T No EVA
rs475728552 513 E>A No EVA
rs1115750607 514 T>N No EVA
rs454764483 514 T>P No EVA
rs460109980 515 S>* No EVA
rs440094532 515 S>A No EVA
rs470584472 516 R>G No EVA
rs439057497 516 R>L No EVA
rs459059298 518 A>S No EVA
rs450988468 519 H>Q No EVA
rs461424424 520 R>M No EVA
rs461424424 520 R>T No EVA
rs481524477 521 L>H No EVA
rs466961540 523 S>A No EVA
rs432352408 523 S>C No EVA
rs432352408 523 S>Y No EVA
rs437947224 525 A>E No EVA
rs469265535 525 A>S No EVA
rs474816841 526 P>A No EVA
rs453762088 528 T>K No EVA
rs433633297 528 T>P No EVA
rs470733064 529 S>A No EVA

No associated diseases with P26285

2 regional properties for P26285

Type Name Position InterPro Accession
active_site Phosphoglycerate/bisphosphoglycerate mutase, active site 255 - 264 IPR001345
domain 6-phosphofructo-2-kinase 28 - 250 IPR013079

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
6-phosphofructo-2-kinase activity Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fructose-2,6-bisphosphate 2-phosphatase activity Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.

3 GO annotations of biological process

Name Definition
fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32604 FBP26 Fructose-2,6-bisphosphatase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P49872 PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Bos taurus (Bovine) PR
P16118 PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Homo sapiens (Human) PR
Q16875 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Homo sapiens (Human) PR
Q16877 PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Homo sapiens (Human) PR
O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Homo sapiens (Human) PR
P70266 Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Mus musculus (Mouse) PR
Q6DTY7 Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Mus musculus (Mouse) PR
P70265 Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Mus musculus (Mouse) PR
O35552 Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Rattus norvegicus (Rat) PR
P07953 Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Rattus norvegicus (Rat) PR
P25114 Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 Rattus norvegicus (Rat) PR
Q9JJH5 Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSGNPASSSE QNNNSYETKA SLRISEKKCS WASYMTNSPT LIVMIGLPAR GKTYVSKKLT
70 80 90 100 110 120
RYLNWIGVPT KVFNLGVYRR QAVKSYKSYD FFRHDNEEAM KIRKQCALVA LKDVKAYLTE
130 140 150 160 170 180
ESGQIAVFDA TNTTRERRDL ILNFAEENSF KVFFVESVCD DPDVIAANIL EVKVSSPDYP
190 200 210 220 230 240
ERNRENVMDD FLKRIECYKV TYQPLDPDSH DKDLSFIKVI NVGQRFLVNK VQDYIQSKIV
250 260 270 280 290 300
YYLMNIHVHP RTIYLCRHGE SEFNLLGKIG GDSGLSVRGK QFAQALRKFL EEQEIADLKV
310 320 330 340 350 360
WTSQLKRTIQ TAESLGVTYE QWKILNEIDA GVCEEMTYAE IQEQYPDEFA LRDEEKYLYR
370 380 390 400 410 420
YPGGESYQDL VQRLEPVIME LERQGNVLVI SHQAVMRCLL AYFLDKGADE LPYLRCPLHT
430 440 450 460 470 480
IFKLTPVAYG CKVETIKLNV EAVNTHRDKP TNNFPKSQTP VRMRRNSFTP LSSSNTIRRP
490 500 510 520 530
RNYSVGSRPL QPLSPLRALD TQEGADQPKT QAETSRAAHR LPSPAPPTSP S