P40433

PR
Gene name
PFK26 (YIL107C)
Protein name
6-phosphofructo-2-kinase 1
Names
6PF-2-K 1, Phosphofructokinase 2 I
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIL107C
EC number
2.7.1.105: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

635-715 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40433

Entry ID Method Resolution Chain Position Source
AF-P40433-F1 Predicted AlphaFoldDB

17 variants for P40433

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-165407 118 K>E No SGRP
s09-165400 120 P>L No SGRP
s09-165068 231 G>R No SGRP
s09-165036 241 E>D No SGRP
s09-164519 414 R>C No SGRP
s09-164501 420 H>N No SGRP
s09-164329 477 G>E No SGRP
s09-164057 568 V>L No SGRP
s09-164014 582 G>D No SGRP
s09-163790 657 F>L No SGRP
s09-163499 754 L>F No SGRP
s09-163471 763 S>F No SGRP
s09-163458 767 N>K No SGRP
s09-163424 779 F>I No SGRP
s09-163405 785 D>G No SGRP
s09-163336 808 D>G No SGRP
s09-163276 828 V>L No SGRP

No associated diseases with P40433

1 regional properties for P40433

Type Name Position InterPro Accession
domain 6-phosphofructo-2-kinase 174 - 395 IPR013079

Functions

Description
EC Number 2.7.1.105 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
6-phosphofructo-2-kinase activity Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

2 GO annotations of biological process

Name Definition
fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase.
fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32604 FBP26 Fructose-2,6-bisphosphatase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MFKPVDFSET SPVPPDIDLA PTQSPHHVAP SQDSSYDLLS RSSDDKIDAE KGPHDELSKH
70 80 90 100 110 120
LPLFQKRPLS DTPISSNWNS PGITEENTPS DSPENSATNL KSLHRLHIND ETQLKNAKIP
130 140 150 160 170 180
TNDTTDYMPP SDGANEVTRI DLKDIKSPTR HHKRRPTTID VPGLTKSKTS PDGLISKEDS
190 200 210 220 230 240
GSKLVIVMVG LPATGKSFIT NKLSRFLNYS LYYCKVFNVG NTRRKFAKEH GLKDQDSKFF
250 260 270 280 290 300
EPKNADSTRL RDKWAMDTLD ELLDYLLEGS GSVGIFDATN TSRERRKNVL ARIRKRSPHL
310 320 330 340 350 360
KVLFLESVCS DHALVQKNIR LKLFGPDYKG KDPESSLKDF KSRLANYLKA YEPIEDDENL
370 380 390 400 410 420
QYIKMIDVGK KVIAYNIQGF LASQTVYYLL NFNLADRQIW ITRSGESEDN VSGRIGGNSH
430 440 450 460 470 480
LTPRGLRFAK SLPKFIARQR EIFYQNLMQQ KKNNENTDGN IYNDFFVWTS MRARTIGTAQ
490 500 510 520 530 540
YFNEDDYPIK QMKMLDELSA GDYDGMTYPE IKNNFPEEFE KRQKDKLRYR YPGIGGESYM
550 560 570 580 590 600
DVINRLRPVI TELERIEDNV LIITHRVVAR ALLGYFMNLS MGIIANLDVP LHCVYCLEPK
610 620 630 640 650 660
PYGITWSLWE YDEASDSFSK VPQTDLNTTR VKEVGLVYNE RRYSVIPTAP PSARSSFASD
670 680 690 700 710 720
FLSRKRSNPT SASSSQSELS EQPKNSVSAQ TGSNNTTLIG SNFNIKNENG DSRIPLSAPL
730 740 750 760 770 780
MATNTSNNIL DGGGTSISIH RPRVVPNQNN VNPLLANNNK AASNVPNVKK SAATPRQIFE
790 800 810 820
IDKVDEKLSM LKNKSFLLHG KDYPNNADNN DNEDIRAKTM NRSQSHV