P25444
PR
Gene name |
Rps2 (Llrep3, Rps4) |
Protein name |
40S ribosomal protein S2 |
Names |
40S ribosomal protein S4, Protein LLRep3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:16898 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for P25444
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7CPU | EM | 282 A | SC | 1-293 | PDB |
| 7CPV | EM | 303 A | SC | 1-293 | PDB |
| 7LS1 | EM | 330 A | J3 | 1-293 | PDB |
| 7LS2 | EM | 310 A | J3 | 1-293 | PDB |
| AF-P25444-F1 | Predicted | AlphaFoldDB |
20 variants for P25444
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs13466464 | 31 | S>G | No | EVA | |
| rs3389448043 | 31 | S>N | No | EVA | |
| rs3389457896 | 41 | G>V | No | EVA | |
| rs3389434150 | 46 | R>* | No | EVA | |
| rs3389389107 | 48 | R>C | No | EVA | |
| rs3389389131 | 53 | G>S | No | EVA | |
| rs3389451606 | 67 | G>D | No | EVA | |
| rs49520359 | 73 | M>I | No | EVA | |
| rs3389420148 | 104 | D>E | No | EVA | |
| rs48913224 | 138 | G>D | No | EVA | |
| rs3389420201 | 140 | G>S | No | EVA | |
| rs3389402014 | 153 | G>W | No | EVA | |
| rs3389409609 | 163 | V>I | No | EVA | |
| rs3406517913 | 166 | R>G | No | EVA | |
| rs3389409693 | 173 | K>T | No | EVA | |
| rs3389389082 | 242 | D>N | No | EVA | |
| rs3389451630 | 251 | L>M | No | EVA | |
| rs3389389125 | 251 | L>P | No | EVA | |
| rs3389439685 | 258 | E>D | No | EVA | |
| rs3389354279 | 270 | T>S | No | EVA |
No associated diseases with P25444
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| cytosolic ribosome | A ribosome located in the cytosol. |
| cytosolic small ribosomal subunit | The small subunit of a ribosome located in the cytosol. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| fibroblast growth factor binding | Binding to a fibroblast growth factor. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to interleukin-4 | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. |
| cytoplasmic translation | The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. |
| positive regulation of ubiquitin-protein transferase activity | Any process that activates, maintains or increases the rate of ubiquitin transferase activity. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O18789 | RPS2 | 40S ribosomal protein S2 | Bos taurus (Bovine) | PR |
| P15880 | RPS2 | 40S ribosomal protein S2 | Homo sapiens (Human) | PR |
| P25444 | Rps2 | 40S ribosomal protein S2 | Mus musculus (Mouse) | PR |
| P27952 | Rps2 | 40S ribosomal protein S2 | Rattus norvegicus (Rat) | PR |
| P93014 | PCMP-H6 | 30S ribosomal protein S5, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADDAGAAGG | PGGPGGPGLG | GRGGFRGGFG | SGLRGRGRGR | GRGRGRGRGA | RGGKAEDKEW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IPVTKLGRLV | KDMKIKSLEE | IYLFSLPIKE | SEIIDFFLGA | SLKDEVLKIM | PVQKQTRAGQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RTRFKAFVAI | GDYNGHVGLG | VKCSKEVATA | IRGAIILAKL | SIVPVRRGYW | GNKIGKPHTV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PCKVTGRCGS | VLVRLIPAPR | GTGIVSAPVP | KKLLMMAGID | DCYTSARGCT | ATLGNFAKAT |
| 250 | 260 | 270 | 280 | 290 | |
| FDAISKTYSY | LTPDLWKETV | FTKSPYQEFT | DHLVKTHTRV | SVQRTQAPAV | ATT |