O18789

PR
Gene name
RPS2
Protein name
40S ribosomal protein S2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:286867
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for O18789

Entry ID Method Resolution Chain Position Source
6MTD EM 330 A CC 58-278 PDB
6MTE EM 340 A CC 58-278 PDB
7SYM EM 480 A D 58-278 PDB
7ZJW EM 280 A SN 1-293 PDB
7ZJX EM 310 A SN 1-293 PDB
8P2K EM 290 A Ab 1-293 PDB
AF-O18789-F1 Predicted AlphaFoldDB

No variants for O18789

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O18789

No associated diseases with O18789

3 regional properties for O18789

Type Name Position InterPro Accession
domain Ribosomal protein S5, C-terminal 186 - 258 IPR005324
domain Ribosomal protein S5, N-terminal 102 - 166 IPR013810
conserved_site Ribosomal protein S5, N-terminal, conserved site 119 - 151 IPR018192

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Probably localized to nucleolus and cytoplasm in complex with ZNF277
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P15880 RPS2 40S ribosomal protein S2 Homo sapiens (Human) PR
P25444 Rps2 40S ribosomal protein S2 Mus musculus (Mouse) PR
P27952 Rps2 40S ribosomal protein S2 Rattus norvegicus (Rat) PR
P93014 PCMP-H6 30S ribosomal protein S5, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADDAGAAGG PGGPGGPGMG GRGGFRGGFG SGVRGRGRGR GRGRGRGRGA RGGKAEDKEW
70 80 90 100 110 120
LPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA SLKDEVLKIM PVQKQTRAGQ
130 140 150 160 170 180
RTRFKAFVAI GDYNGHVGLG VKCSKEVATA IRGAIILAKL SIVPVRRGYW GNKIGKPHTV
190 200 210 220 230 240
PCKVTGRCGS VLVRLIPAPR GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT
250 260 270 280 290
FDAISKTYSY LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT