P27952

PR
Gene name
Rps2
Protein name
40S ribosomal protein S2
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:83789
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-87 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P27952

Entry ID Method Resolution Chain Position Source
7QGG EM 286 A SC 1-293 PDB
AF-P27952-F1 Predicted AlphaFoldDB

No variants for P27952

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27952

No associated diseases with P27952

3 regional properties for P27952

Type Name Position InterPro Accession
domain Ribosomal protein S5, C-terminal 186 - 258 IPR005324
domain Ribosomal protein S5, N-terminal 102 - 166 IPR013810
conserved_site Ribosomal protein S5, N-terminal, conserved site 119 - 151 IPR018192

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
  • Probably localized to nucleolus and cytoplasm in complex with ZNF277
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosolic ribosome A ribosome located in the cytosol.
cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

5 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
fibroblast growth factor binding Binding to a fibroblast growth factor.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
protein-containing complex binding Binding to a macromolecular complex.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

6 GO annotations of biological process

Name Definition
cellular response to interleukin-4 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
formation of translation preinitiation complex The joining of the small ribosomal subunit, ternary complex, and mRNA.
positive regulation of ubiquitin-protein transferase activity Any process that activates, maintains or increases the rate of ubiquitin transferase activity.
response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O18789 RPS2 40S ribosomal protein S2 Bos taurus (Bovine) PR
P15880 RPS2 40S ribosomal protein S2 Homo sapiens (Human) PR
P25444 Rps2 40S ribosomal protein S2 Mus musculus (Mouse) PR
P93014 PCMP-H6 30S ribosomal protein S5, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADDAGAAGG PGGPGGPGLG GRGGFRGGFG SGLRGRGRGR GRGRGRGRGA RGGKAEDKEW
70 80 90 100 110 120
IPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA SLKDEVLKIM PVQKQTRAGQ
130 140 150 160 170 180
RTRFKAFVAI GDYNGHVGLG VKCSKEVATA IRGAIILAKL SIVPVRRGYW GNKIGKPHTV
190 200 210 220 230 240
PCKVTGRCGS VLVRLIPAPR GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT
250 260 270 280 290
FDAISKTYSY LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT