AiPD: Autoinhibited Protein Database

P15880

Gene name	RPS2 (RPS4)
Protein name	40S ribosomal protein S2
Names	40S ribosomal protein S4, Protein LLRep3, Small ribosomal subunit protein uS5
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6187
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-90 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-90 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

91 structures for P15880

Entry ID	Method	Resolution	Chain	Position	Source
4UG0	EM	-	SC	1-293	PDB
4V6X	EM	500 A	AC	1-293	PDB
5A2Q	EM	390 A	C	1-293	PDB
5AJ0	EM	350 A	BC	1-293	PDB
5FLX	EM	390 A	C	1-293	PDB
5LKS	EM	360 A	SC	1-293	PDB
5OA3	EM	430 A	C	1-293	PDB
5T2C	EM	360 A	AJ	1-293	PDB
5VYC	X-ray	600 A	C1/C2/C3/C4/C5/C6	1-293	PDB
6G18	EM	360 A	C	1-293	PDB
6G4S	EM	400 A	C	1-293	PDB
6G51	EM	410 A	C	1-293	PDB
6G53	EM	450 A	C	1-293	PDB
6G5H	EM	360 A	C	1-293	PDB
6G5I	EM	350 A	C	1-293	PDB
6IP5	EM	390 A	3G	1-293	PDB
6IP6	EM	450 A	3G	1-293	PDB
6IP8	EM	390 A	3G	1-293	PDB
6OLE	EM	310 A	SC	59-278	PDB
6OLF	EM	390 A	SC	59-278	PDB
6OLG	EM	340 A	BC	57-278	PDB
6OLI	EM	350 A	SC	59-278	PDB
6OLZ	EM	390 A	BC	57-278	PDB
6OM0	EM	310 A	SC	59-278	PDB
6OM7	EM	370 A	SC	59-278	PDB
6QZP	EM	290 A	SC	59-280	PDB
6XA1	EM	280 A	SC	59-278	PDB
6Y0G	EM	320 A	SC	1-293	PDB
6Y2L	EM	300 A	SC	1-293	PDB
6Y57	EM	350 A	SC	1-293	PDB
6YBD	EM	330 A	L	1-293	PDB
6YBW	EM	310 A	L	1-293	PDB
6Z6L	EM	300 A	SC	1-293	PDB
6Z6M	EM	310 A	SC	1-293	PDB
6Z6N	EM	290 A	SC	1-293	PDB
6ZLW	EM	260 A	D	1-293	PDB
6ZM7	EM	270 A	SC	1-293	PDB
6ZME	EM	300 A	SC	1-293	PDB
6ZMI	EM	260 A	SC	1-293	PDB
6ZMO	EM	310 A	SC	1-293	PDB
6ZMT	EM	300 A	D	1-293	PDB
6ZMW	EM	370 A	L	1-293	PDB
6ZN5	EM	320 A	D	59-276	PDB
6ZOJ	EM	280 A	C	1-293	PDB
6ZOK	EM	280 A	C	1-293	PDB
6ZON	EM	300 A	d	1-293	PDB
6ZP4	EM	290 A	d	1-293	PDB
6ZUO	EM	310 A	C	1-293	PDB
6ZV6	EM	290 A	C	1-293	PDB
6ZVH	EM	290 A	C	59-280	PDB
6ZVJ	EM	380 A	d	60-275	PDB
6ZXD	EM	320 A	C	1-293	PDB
6ZXE	EM	300 A	C	1-293	PDB
6ZXF	EM	370 A	C	1-293	PDB
6ZXG	EM	260 A	C	1-293	PDB
6ZXH	EM	270 A	C	1-293	PDB
7A09	EM	350 A	d	1-293	PDB
7JQB	EM	270 A	D	1-293	PDB
7JQC	EM	330 A	D	1-293	PDB
7K5I	EM	290 A	C	1-293	PDB
7QP6	EM	470 A	L	1-293	PDB
7QP7	EM	370 A	L	1-293	PDB
7QVP	EM	300 A	RC/SC	1-293	PDB
7R4X	EM	215 A	C	1-293	PDB
7TQL	EM	340 A	D	59-276	PDB
7WTV	EM	350 A	C	1-293	PDB
7WTW	EM	320 A	C	1-293	PDB
7WTX	EM	310 A	C	1-293	PDB
7WTZ	EM	300 A	C	1-293	PDB
7WU0	EM	330 A	C	1-293	PDB
7XNX	EM	270 A	SC	1-293	PDB
7XNY	EM	250 A	SC	1-293	PDB
8G5Y	EM	229 A	SC	1-293	PDB
8G5Z	EM	264 A	SC	59-280	PDB
8G60	EM	254 A	SC	1-293	PDB
8G61	EM	294 A	SC	1-293	PDB
8G6J	EM	280 A	SC	1-293	PDB
8GLP	EM	167 A	SC	1-293	PDB
8IFD	EM	259 A	3G	1-293	PDB
8IFE	EM	257 A	3G	1-293	PDB
8JDJ	EM	250 A	z	1-293	PDB
8JDK	EM	226 A	z	1-293	PDB
8JDL	EM	242 A	z	1-293	PDB
8JDM	EM	267 A	z	1-293	PDB
8OZ0	EM	350 A	O	1-293	PDB
8PPK	EM	298 A	C	1-293	PDB
8PPL	EM	265 A	AC	1-293	PDB
8T4S	EM	260 A	C	1-293	PDB
8Y0W	EM	340 A	SC	1-293	PDB
8Y0X	EM	330 A	SC	1-293	PDB
AF-P15880-F1	Predicted				AlphaFoldDB

222 variants for P15880

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA394272852 rs1567318687	2	A>G		No	ClinGen Ensembl
CA7823903 rs770974083	6	G>A		No	ClinGen ExAC gnomAD
TCGA novel	6	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762654490 CA7823901	7	A>E		No	ClinGen ExAC TOPMed gnomAD
CA7823902 rs747260490	7	A>T		No	ClinGen ExAC gnomAD
rs762654490 CA394272790	7	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7823900 rs772256506	8	A>T		No	ClinGen ExAC
rs1223985092 CA394272784	8	A>V		No	ClinGen gnomAD
rs989713704 CA394272771	9	G>A		No	ClinGen TOPMed gnomAD
rs989713704 CA276754449	9	G>E		No	ClinGen TOPMed gnomAD
CA276754462 rs12397561 CA7823898	9	G>R		No	ClinGen ExAC gnomAD
rs989713704 CA394272768	9	G>V		No	ClinGen TOPMed gnomAD
CA394272774 rs12397561	9	G>W		No	ClinGen ExAC gnomAD
rs1304830476 CA394272759	10	G>A		No	ClinGen gnomAD
CA276754444 rs958307866	10	G>R		No	ClinGen Ensembl
rs780574188 CA7823894	11	P>L		No	ClinGen ExAC gnomAD
CA394272749 rs199558614	11	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7823896 rs199558614	11	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA276754404 CA7823892 rs751281003	12	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	12	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7823893 rs751281003	12	G>W		No	ClinGen ExAC TOPMed gnomAD
CA394272716 rs1158100558	13	G>D		No	ClinGen gnomAD
rs752493327 CA7823889	14	P>L		No	ClinGen ExAC gnomAD
rs1197854287 CA394272699	15	G>S		No	ClinGen gnomAD
CA7823888 rs7204258	16	G>A		No	ClinGen ExAC TOPMed gnomAD
CA276754394 rs7204258	16	G>V		No	ClinGen ExAC TOPMed gnomAD
rs753857917	16	G>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs759395923 CA7823887	17	P>L		No	ClinGen ExAC gnomAD
rs532422534 CA7823886	18	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA7823883 CA7823882 rs760788760	19	M>I		No	ClinGen ExAC gnomAD
rs1462933757 CA394272617	20	G>E		No	ClinGen gnomAD
rs1281652651 CA394272620	20	G>R		No	ClinGen gnomAD
rs773241417 CA276754367	21	N>I		No	ClinGen ExAC TOPMed gnomAD
rs773241417 CA7823881	21	N>S		No	ClinGen ExAC TOPMed gnomAD
rs772350714 CA7823880	22	R>S		No	ClinGen ExAC gnomAD
CA394272581 rs11543072	23	G>D		No	ClinGen gnomAD
rs1344704493 CA394272583	23	G>R		No	ClinGen TOPMed gnomAD
rs1344704493 CA394272585	23	G>S		No	ClinGen TOPMed gnomAD
CA276754365 rs11543072	23	G>V		No	ClinGen gnomAD
CA7823879 rs748360461	24	G>S		No	ClinGen ExAC gnomAD
rs11538721 CA394272551	27	G>E		No	ClinGen gnomAD
rs11538721 CA276754359	27	G>V		No	ClinGen gnomAD
CA394272549 rs1597039617	28	G>S		No	ClinGen Ensembl
CA276754356 rs11543094	28	G>V		No	ClinGen Ensembl
CA394272502 rs1174971944	32	G>S		No	ClinGen TOPMed gnomAD
rs1365798435 CA394272471	35	G>S		No	ClinGen TOPMed
TCGA novel	36	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7823876 rs749792856	38	R>H		No	ClinGen ExAC gnomAD
rs780562414 CA7823875	40	R>G		No	ClinGen ExAC TOPMed gnomAD
CA394272351 rs1328635891	41	G>V		No	ClinGen TOPMed
rs756667522 CA7823872	42	R>W		No	ClinGen ExAC TOPMed gnomAD
rs746558635 CA7823871	45	G>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	48	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7823864 rs752326265	49	G>A		No	ClinGen ExAC gnomAD
rs1322740881 CA394272219	50	A>P		No	ClinGen gnomAD
CA7823863 rs764971592	50	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA394272201 rs1359566012	52	G>R		No	ClinGen gnomAD
rs1334790430 CA394272163	55	A>D		No	ClinGen gnomAD
TCGA novel	55	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1334790430 CA394272159	55	A>V		No	ClinGen gnomAD
TCGA novel	56	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753552285 CA7823860	56	E>Q		No	ClinGen ExAC
CA276754132 rs1029985840 CA394272087	60	W>C		No	ClinGen TOPMed
rs139767914 CA7823820 CA7823821	61	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1222079959 CA394272081	61	M>L		No	ClinGen TOPMed gnomAD
rs1222079959 CA394272082	61	M>V		No	ClinGen TOPMed gnomAD
CA394272071 rs866276648	62	P>A		No	ClinGen TOPMed
CA276754127 rs866276648	62	P>S		No	ClinGen TOPMed
CA394272052 rs1597039341	63	V>G		No	ClinGen Ensembl
rs1364094385 CA394272032	65	K>M		No	ClinGen gnomAD
rs763240039 CA7823815	67	G>D		No	ClinGen ExAC gnomAD
CA7823814 rs368176620	68	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA394271988 rs1195590985	69	L>F		No	ClinGen gnomAD
rs1411219537 CA394271968	71	K>M		No	ClinGen gnomAD
rs1428215411 CA394271965 CA394271963	71	K>N		No	ClinGen TOPMed
rs771532107 CA7823810	72	D>N		No	ClinGen ExAC TOPMed gnomAD
CA276754093 rs773232994	73	M>I		No	ClinGen Ensembl
CA394271909 rs1266498173	75	I>N		No	ClinGen TOPMed gnomAD
rs1208958881 CA394271901	76	K>R		No	ClinGen TOPMed gnomAD
rs1567318373 CA394271892	77	S>A		No	ClinGen Ensembl
CA7823809 rs761069719	77	S>F		No	ClinGen ExAC TOPMed gnomAD
CA394271888 rs761069719	77	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA394271883 rs746887497	78	L>V		No	ClinGen TOPMed
CA7823807 rs767988974	79	E>A		No	ClinGen ExAC gnomAD
rs374258583 CA394271851	80	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1015985571 CA276754082	80	E>G		No	ClinGen Ensembl
CA7823804 rs769415014	81	I>M		No	ClinGen ExAC gnomAD
rs745704132 CA276754069	82	Y>C		No	ClinGen ExAC gnomAD
CA7823803 rs745704132	82	Y>F		No	ClinGen ExAC gnomAD
rs1201265849 CA394271819	83	L>V		No	ClinGen TOPMed
rs370163380 CA7823799	85	S>F		No	ClinGen ESP ExAC gnomAD
rs752801500 CA394271734	87	P>A		No	ClinGen ExAC TOPMed gnomAD
rs752801500 CA7823795	87	P>S		No	ClinGen ExAC TOPMed gnomAD
CA7823747 rs757776418	98	L>R		No	ClinGen ExAC gnomAD
rs751997551 CA7823746	100	A>V		No	ClinGen ExAC gnomAD
rs1207931958 CA394270304	101	S>F		No	ClinGen gnomAD
CA276753389 rs990662419	103	K>E		No	ClinGen TOPMed
rs764747805 CA7823745	103	K>N		No	ClinGen ExAC gnomAD
rs1297107737 CA394270261	105	E>D		No	ClinGen gnomAD
CA7823744 rs759094044	105	E>K		No	ClinGen ExAC gnomAD
rs1340327640 CA394270262	105	E>V		No	ClinGen gnomAD
CA7823742 rs766012844	110	M>T		No	ClinGen ExAC gnomAD
CA276753386 rs1035105096	113	Q>*		No	ClinGen TOPMed
rs760357971 CA7823741	117	R>C		No	ClinGen ExAC TOPMed gnomAD
CA394270131 rs1368370305	117	R>H		No	ClinGen gnomAD
rs867556469 CA276753383	119	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1597037811 CA394270067	121	R>C		No	ClinGen Ensembl
CA394270062 rs1415317836	121	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA394270052 rs1179553053	122	T>I		No	ClinGen gnomAD
rs924906278 CA276753283	126	A>S		No	ClinGen Ensembl
rs11543107 CA276753282	126	A>V		No	ClinGen Ensembl
rs1429351694 CA394269825	129	A>D		No	ClinGen TOPMed gnomAD
rs1429351694 CA394269822	129	A>V		No	ClinGen TOPMed gnomAD
rs1165095549 CA394269808	131	G>R		No	ClinGen gnomAD
rs766466013 CA7823650	133	Y>*		No	ClinGen ExAC gnomAD
rs11543098 CA7823649	134	N>D		No	ClinGen ExAC TOPMed gnomAD
CA276753252 rs11543098	134	N>H		No	ClinGen ExAC TOPMed gnomAD
rs201628829 CA7823648	134	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767849793 CA7823647	135	G>A		No	ClinGen ExAC gnomAD
CA7823644 rs769075167	137	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1353635350 CA394269732	138	G>S		No	ClinGen gnomAD
CA394269658 rs1388559512	144	S>F		No	ClinGen Ensembl
rs927854415 CA276753238	145	K>R		No	ClinGen TOPMed
CA394269615 rs1597037291	147	V>G		No	ClinGen Ensembl
rs778796528 CA7823635	154	A>S		No	ClinGen ExAC gnomAD
rs753605404 CA7823633	156	I>V		No	ClinGen ExAC gnomAD
CA394269451 rs1246988614	157	L>P		No	ClinGen gnomAD
rs750576891 CA7823630	159	K>M		No	ClinGen ExAC gnomAD
rs767441011 CA7823629	159	K>N		No	ClinGen ExAC gnomAD
CA394269374 rs1466214610	162	I>V		No	ClinGen gnomAD
CA394269350 rs1227600615	163	V>F		No	ClinGen TOPMed gnomAD
CA394269355 rs1227600615	163	V>I		No	ClinGen TOPMed gnomAD
CA394269338 rs1238607990	164	P>A		No	ClinGen TOPMed
CA394269329 rs1345449379	164	P>H		No	ClinGen gnomAD
CA394269316 rs1231356093	165	V>L		No	ClinGen gnomAD
CA394269303 rs1330678784	166	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1567317156 CA394269298	166	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1321337545 CA394269293	167	R>G		No	ClinGen gnomAD
CA394269268 rs1387106171	168	G>A		No	ClinGen TOPMed
CA7823624 rs543253316	172	N>D		No	ClinGen 1000Genomes ExAC gnomAD
rs11543118 CA276753208	173	K>N		No	ClinGen Ensembl
CA394269133 rs770479865	174	I>M		No	ClinGen ExAC TOPMed gnomAD
rs759902795 CA7823622	175	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1427710783 CA394269076	177	P>T		No	ClinGen gnomAD
rs1171113495 CA394269052	178	H>R		No	ClinGen gnomAD
rs11543074 CA276753200	178	H>Y		No	ClinGen Ensembl
CA394268997 rs1376665253	181	P>S		No	ClinGen gnomAD
CA394268962 rs1188695244	183	K>R		No	ClinGen TOPMed gnomAD
rs1264827706 CA394268839	184	V>M		No	ClinGen TOPMed
CA7823596 rs748885661	187	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs775271566 CA7823595	187	R>H		No	ClinGen ExAC TOPMed gnomAD
CA276753137 rs11543075	188	C>R		No	ClinGen Ensembl
COSM3420817 rs76844476 CA276753134	194	R>C	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA7823592 rs76844476	194	R>S		No	ClinGen ExAC gnomAD
CA394268603 rs1251329879	197	P>L		No	ClinGen gnomAD
rs566623400 CA7823590	198	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs566623400 CA394268601	198	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA276753121 rs17856937	202	T>I		No	ClinGen Ensembl
TCGA novel	205	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs533119033 CA7823584	208	P>H		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	210	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7823582 rs761232903	211	K>R		No	ClinGen ExAC gnomAD
CA7823580 rs763531958	213	L>V		No	ClinGen ExAC TOPMed gnomAD
rs775074747 CA7823578	215	M>L		No	ClinGen ExAC TOPMed gnomAD
rs769466457 CA7823577	215	M>T		No	ClinGen ExAC gnomAD
rs1003181864 CA276753046	218	G>S		No	ClinGen TOPMed
TCGA novel	219	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394268228 rs1412555185	219	I>V		No	ClinGen gnomAD
rs145914766 CA7823574	220	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1398145021 CA394268211	220	D>N		No	ClinGen TOPMed
CA7823573 rs746875524	222	C>S		No	ClinGen ExAC gnomAD
CA276753019 rs929142323	224	T>I		No	ClinGen TOPMed
rs1217398563 CA394268117	225	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7823570 rs748212461	227	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7823571 rs369095700	227	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs779039730 CA7823569	228	G>S		No	ClinGen ExAC TOPMed gnomAD
rs754211411 CA7823567	230	T>A		No	ClinGen ExAC gnomAD
CA394267994 rs1219448992	230	T>S		No	ClinGen gnomAD
rs780411000 CA7823566	231	A>V		No	ClinGen ExAC gnomAD
rs750894365 CA7823564	237	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7823478 rs748534788	243	A>G		No	ClinGen ExAC gnomAD
rs11543069 CA276752636	245	S>F		No	ClinGen Ensembl
TCGA novel	245	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	247	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA276752629 rs11539480	247	T>N		No	ClinGen Ensembl
CA394266192 rs1452021980	251	L>V		No	ClinGen gnomAD
CA276751374 rs11543112	252	T>N		No	ClinGen Ensembl
rs1466154917 CA394266158	253	P>H		No	ClinGen gnomAD
rs374773804 CA7823474	254	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA394266145 rs1259319580	254	D>G		No	ClinGen TOPMed
rs1192932025 CA394266151	254	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1346027608 CA394266056	259	T>S		No	ClinGen gnomAD
rs751433066 CA7823472	260	V>I		No	ClinGen ExAC gnomAD
CA394266031 rs777377021	261	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA276751302 rs1051537930	264	S>P		No	ClinGen TOPMed
CA394265960 rs1437914020	266	Y>F		No	ClinGen gnomAD
CA394265946 rs1361313392	267	Q>H		No	ClinGen TOPMed
CA394265891 rs1597036480	271	D>A		No	ClinGen Ensembl
CA276751279 rs3211583	272	H>P		No	ClinGen Ensembl
CA7823466 rs753906824	274	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1393972551 CA394265826	276	T>A		No	ClinGen gnomAD
rs760750249 CA7823464	276	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1393972551 CA394265827	276	T>P		No	ClinGen gnomAD
rs772283358 CA7823462	278	T>A		No	ClinGen ExAC TOPMed gnomAD
CA394265795 rs772283358	278	T>P		No	ClinGen ExAC TOPMed gnomAD
rs762435329 CA7823461	279	R>K		No	ClinGen ExAC gnomAD
CA276751181 rs992070916	280	V>A		No	ClinGen Ensembl
rs140783691 CA7823458	280	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs140783691 CA394265766	280	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs140783691 CA7823459	280	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs142405634 CA7823456	282	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1230644525 CA394265730	283	Q>*		No	ClinGen gnomAD
CA7823454 rs367578393	284	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs746578617 CA7823455	284	R>W		No	ClinGen ExAC TOPMed gnomAD
CA394265697 rs758173961	285	T>I		No	ClinGen ExAC TOPMed gnomAD
rs758173961 CA7823453	285	T>S		No	ClinGen ExAC TOPMed gnomAD
CA7823452 rs752453825	286	Q>*		No	ClinGen ExAC gnomAD
CA394265673 rs1168272425	287	A>V		No	ClinGen Ensembl
rs1056415734 CA276751160	288	P>L		No	ClinGen TOPMed
CA394265667 rs1180756035	288	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	289	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778885599 CA7823450	289	A>V		No	ClinGen ExAC gnomAD

No associated diseases with P15880

3 regional properties for P15880

Type	Name	Position	InterPro Accession
domain	Ribosomal protein S5, C-terminal	186 - 258	IPR005324
domain	Ribosomal protein S5, N-terminal	102 - 166	IPR013810
conserved_site	Ribosomal protein S5, N-terminal, conserved site	119 - 151	IPR018192

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus, nucleolus	Probably localized to nucleolus and cytoplasm in complex with ZNF277
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic ribosome	A ribosome located in the cytosol.
cytosolic small ribosomal subunit	The small subunit of a ribosome located in the cytosol.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
fibroblast growth factor binding	Binding to a fibroblast growth factor.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

3 GO annotations of biological process

Name	Definition
cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
positive regulation of ubiquitin-protein transferase activity	Any process that activates, maintains or increases the rate of ubiquitin transferase activity.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O18789	RPS2	40S ribosomal protein S2	Bos taurus (Bovine)	PR
P25444	Rps2	40S ribosomal protein S2	Mus musculus (Mouse)	PR
P27952	Rps2	40S ribosomal protein S2	Rattus norvegicus (Rat)	PR
P93014	PCMP-H6	30S ribosomal protein S5, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MADDAGAAGG	PGGPGGPGMG	NRGGFRGGFG	SGIRGRGRGR	GRGRGRGRGA	RGGKAEDKEW
70	80	90	100	110	120
MPVTKLGRLV	KDMKIKSLEE	IYLFSLPIKE	SEIIDFFLGA	SLKDEVLKIM	PVQKQTRAGQ
130	140	150	160	170	180
RTRFKAFVAI	GDYNGHVGLG	VKCSKEVATA	IRGAIILAKL	SIVPVRRGYW	GNKIGKPHTV
190	200	210	220	230	240
PCKVTGRCGS	VLVRLIPAPR	GTGIVSAPVP	KKLLMMAGID	DCYTSARGCT	ATLGNFAKAT
250	260	270	280	290
FDAISKTYSY	LTPDLWKETV	FTKSPYQEFT	DHLVKTHTRV	SVQRTQAPAV	ATT