P22226

PR
Gene name
CATHL1 (BAC1)
Protein name
Cathelicidin-1
Names
Bactenecin-1, Bac1, Cyclic dodecapeptide
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282164
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P22226

Entry ID Method Resolution Chain Position Source
AF-P22226-F1 Predicted AlphaFoldDB

1 variants for P22226

Variant ID(s) Position Change Description Diseaes Association Provenance
128 Q>R No

No associated diseases with P22226

2 regional properties for P22226

Type Name Position InterPro Accession
conserved_site Cathelicidin, conserved site 34 - 47 IPR018216-1
conserved_site Cathelicidin, conserved site 78 - 100 IPR018216-2

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
lipopolysaccharide binding Binding to a lipopolysaccharide.

5 GO annotations of biological process

Name Definition
antimicrobial humoral immune response mediated by antimicrobial peptide An immune response against microbes mediated by anti-microbial peptides in body fluid.
cytolysis The rupture of cell membranes and the loss of cytoplasm.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22226 CATHL1 Cathelicidin-1 Bos taurus (Bovine) PR
P54228 CATHL6 Cathelicidin-6 Bos taurus (Bovine) PR
P56425 CATHL7 Cathelicidin-7 Bos taurus (Bovine) PR
Q2IAL7 CATHL2 Cathelicidin-2 Gallus gallus (Chicken) PR
P80054 PR39 Antibacterial protein PR-39 Sus scrofa (Pig) PR
10 20 30 40 50 60
METPRASLSL GRWSLWLLLL GLALPSASAQ ALSYREAVLR AVDQLNEQSS EPNIYRLLEL
70 80 90 100 110 120
DQPPQDDEDP DSPKRVSFRV KETVCSRTTQ QPPEQCDFKE NGLLKRCEGT VTLDQVRGNF
130 140 150
DITCNNHQSI RITKQPWAPP QAARLCRIVV IRVCR