P80054

PR
Gene name
PR39
Protein name
Antibacterial protein PR-39
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:407610
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-172 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P80054

Entry ID Method Resolution Chain Position Source
4EZO X-ray 190 A C/D 131-145 PDB
AF-P80054-F1 Predicted AlphaFoldDB

No variants for P80054

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P80054

No associated diseases with P80054

4 regional properties for P80054

Type Name Position InterPro Accession
domain TolB, N-terminal 22 - 128 IPR007195
repeat WD40-like beta propeller 242 - 271 IPR011659-1
repeat WD40-like beta propeller 282 - 316 IPR011659-2
repeat WD40-like beta propeller 325 - 349 IPR011659-3

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
lipopolysaccharide binding Binding to a lipopolysaccharide.

4 GO annotations of biological process

Name Definition
antimicrobial humoral immune response mediated by antimicrobial peptide An immune response against microbes mediated by anti-microbial peptides in body fluid.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22226 CATHL1 Cathelicidin-1 Bos taurus (Bovine) PR
P54228 CATHL6 Cathelicidin-6 Bos taurus (Bovine) PR
Q2IAL7 CATHL2 Cathelicidin-2 Gallus gallus (Chicken) PR
10 20 30 40 50 60
METQRASLCL GRWSLWLLLL GLVVPSASAQ ALSYREAVLR AVDRLNEQSS EANLYRLLEL
70 80 90 100 110 120
DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE NGRVKQCVGT VTLNPSIHSL
130 140 150 160 170
DISCNEIQSV RRRPRPPYLP RPRPPPFFPP RLPPRIPPGF PPRFPPRFPG KR