Q2IAL7

PR
Gene name
CATHL2 (CMAP27)
Protein name
Cathelicidin-2
Names
CATH-2, Fowlicidin-2, Myeloid antimicrobial peptide 27
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:420407
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2IAL7

Entry ID Method Resolution Chain Position Source
AF-Q2IAL7-F1 Predicted AlphaFoldDB

No variants for Q2IAL7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2IAL7

No associated diseases with Q2IAL7

No regional properties for Q2IAL7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q2IAL7

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name Definition
lipopolysaccharide binding Binding to a lipopolysaccharide.

7 GO annotations of biological process

Name Definition
antimicrobial humoral immune response mediated by antimicrobial peptide An immune response against microbes mediated by anti-microbial peptides in body fluid.
cytolysis The rupture of cell membranes and the loss of cytoplasm.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
macrophage activation A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
negative regulation of cytokine production Any process that stops, prevents, or reduces the rate of production of a cytokine.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22226 CATHL1 Cathelicidin-1 Bos taurus (Bovine) PR
P54228 CATHL6 Cathelicidin-6 Bos taurus (Bovine) PR
P56425 CATHL7 Cathelicidin-7 Bos taurus (Bovine) PR
P80054 PR39 Antibacterial protein PR-39 Sus scrofa (Pig) PR
10 20 30 40 50 60
MLSCWVLLLA LLGGVCALPA PLSYPQALIQ AVDSYNQRPE VQNAFRLLSA DPEPGPGVDL
70 80 90 100 110 120
STLRALNFTI METECTPSAR LPVDDCDFKE NGVIRDCSGP VSVLQDTPEI NLRCRDASSD
130 140 150
PVLVQRGRFG RFLRKIRRFR PKVTITIQGS ARFG