P54228
Gene name |
CATHL6 (BMAP27) |
Protein name |
Cathelicidin-6 |
Names |
Antibacterial peptide BMAP-27, Myeloid antibacterial peptide 27 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:317651 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P54228
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2KET | NMR | - | A | 132-157 | PDB |
| AF-P54228-F1 | Predicted | AlphaFoldDB |
61 variants for P54228
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs453117335 | 3 | T>P | No | EVA | |
| rs442937875 | 4 | Q>H | No | EVA | |
| rs461385491 | 4 | Q>K | No | EVA | |
| rs472596829 | 6 | A>P | No | EVA | |
| rs439062975 | 8 | L>P | No | EVA | |
| rs471844100 | 10 | L>R | No | EVA | |
| rs474248566 | 13 | W>C | No | EVA | |
| rs438109516 | 13 | W>G | No | EVA | |
| rs438109516 | 13 | W>R | No | EVA | |
| rs455534013 | 14 | S>A | No | EVA | |
| rs445154160 | 16 | W>C | No | EVA | |
| rs466763271 | 16 | W>L | No | EVA | |
| rs450356250 | 21 | G>A | No | EVA | |
| rs461720414 | 24 | L>P | No | EVA | |
| rs461720414 | 24 | L>R | No | EVA | |
| rs480132317 | 24 | L>V | No | EVA | |
| rs479042362 | 25 | P>A | No | EVA | |
| rs479042362 | 25 | P>S | No | EVA | |
| rs460685241 | 28 | S>R | No | EVA | |
| rs439102551 | 30 | Q>* | No | EVA | |
| rs472045494 | 31 | A>V | No | EVA | |
| rs462961729 | 33 | S>R | No | EVA | |
| rs444402752 | 36 | E>V | No | EVA | |
| rs474181435 | 38 | V>L | No | EVA | |
| rs434045199 | 40 | R>L | No | EVA | |
| rs434045199 | 40 | R>P | No | EVA | |
| rs473248573 | 43 | D>E | No | EVA | |
| rs451369041 | 46 | N>K | No | EVA | |
| rs723195115 | 52 | A>V | No | EVA | |
| rs469215876 | 53 | N>I | No | EVA | |
| rs450758294 | 55 | Y>C | No | EVA | |
| rs435201971 | 56 | R>G | No | EVA | |
| rs467986974 | 56 | R>L | No | EVA | |
| rs479277653 | 59 | E>D | No | EVA | |
| rs460773860 | 60 | L>P | No | EVA | |
| rs463252816 | 63 | P>L | No | EVA | |
| rs207956101 | 64 | P>L | No | EVA | |
| rs462122910 | 67 | D>E | No | EVA | |
| rs474220152 | 67 | D>H | No | EVA | |
| rs452044869 | 68 | D>E | No | EVA | |
| rs436883984 | 69 | E>K | No | EVA | |
| rs476264342 | 71 | P>R | No | EVA | |
| rs435823660 | 72 | N>T | No | EVA | |
| rs468750631 | 73 | I>M | No | EVA | |
| rs447136037 | 74 | P>L | No | EVA | |
| rs435042896 | 75 | K>E | No | EVA | |
| rs464548225 | 75 | K>N | No | EVA | |
| rs445978078 | 78 | S>I | No | EVA | |
| rs482386479 | 81 | V>G | No | EVA | |
| rs463726426 | 89 | T>P | No | EVA | |
| rs109041342 | 95 | E>Q | No | EVA | |
| rs81183061 | 102 | N>K | No | EVA | |
| rs81109660 | 121 | I>M | No | EVA | |
| rs81109661 | 126 | E>K | No | EVA | |
| rs466104221 | 130 | S>R | No | EVA | |
| rs454241760 | 133 | R>T | No | EVA | |
| rs432444224 | 134 | F>Y | No | EVA | |
| rs1114827094 | 138 | R>H | No | EVA | |
| rs437908664 | 145 | F>L | No | EVA | |
| rs467708923 | 147 | K>N | No | EVA | |
| rs452420297 | 156 | H>R | No | EVA |
No associated diseases with P54228
5 regional properties for P54228
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | TolB, N-terminal | 23 - 126 | IPR007195 |
| repeat | WD40-like beta propeller | 208 - 237 | IPR011659-1 |
| repeat | WD40-like beta propeller | 248 - 284 | IPR011659-2 |
| repeat | WD40-like beta propeller | 292 - 328 | IPR011659-3 |
| repeat | WD40-like beta propeller | 338 - 370 | IPR011659-4 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipopolysaccharide binding | Binding to a lipopolysaccharide. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| antimicrobial humoral immune response mediated by antimicrobial peptide | An immune response against microbes mediated by anti-microbial peptides in body fluid. |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| defense response to Gram-negative bacterium | Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. |
| defense response to Gram-positive bacterium | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| killing of cells of another organism | Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. |
4 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| METQRASLSL | GRWSLWLLLL | GLALPSASAQ | ALSYREAVLR | AVDQFNERSS | EANLYRLLEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DPPPKEDDEN | PNIPKPVSFR | VKETVCPRTS | QQPAEQCDFK | ENGLVKQCVG | TVTLDAVKGK |
| 130 | 140 | 150 | |||
| INVTCEELQS | VGRFKRFRKK | FKKLFKKLSP | VIPLLHLG |