P0CH31

PR
Gene name
At1g43140 (F1I21.19)
Protein name
Putative cullin-like protein 1
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G43140
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

585-675 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CH31

Entry ID Method Resolution Chain Position Source
AF-P0CH31-F1 Predicted AlphaFoldDB

165 variants for P0CH31

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01265838 2 A>D No 1000Genomes
ENSVATH04835741 5 L>F No 1000Genomes
tmp_1_16232929_TA_GA,T 9 I>R No 1000Genomes
ENSVATH13294906 11 M>K No 1000Genomes
ENSVATH13294905 11 M>V No 1000Genomes
ENSVATH01265844 13 E>K No 1000Genomes
ENSVATH01265845 14 L>I No 1000Genomes
ENSVATH00077194 18 E>D No 1000Genomes
ENSVATH04835743 23 V>L No 1000Genomes
ENSVATH00077195 25 K>E No 1000Genomes
ENSVATH04835744 26 T>I No 1000Genomes
tmp_1_16232994_C_A 31 L>I No 1000Genomes
ENSVATH13294909 36 E>K No 1000Genomes
ENSVATH13294910 44 D>E No 1000Genomes
ENSVATH04835745 45 P>A No 1000Genomes
ENSVATH04835745 45 P>S No 1000Genomes
ENSVATH01265849 46 G>R No 1000Genomes
ENSVATH01265849 46 G>S No 1000Genomes
ENSVATH04835749 54 I>T No 1000Genomes
ENSVATH04835750 62 Q>K No 1000Genomes
tmp_1_16233168_G_A 66 D>N No 1000Genomes
ENSVATH01265855 72 Y>C No 1000Genomes
ENSVATH13294947 73 N>I No 1000Genomes
ENSVATH00077198 79 V>I No 1000Genomes
ENSVATH01265856 81 H>D No 1000Genomes
tmp_1_16233219_A_G 83 N>D No 1000Genomes
ENSVATH01265860 98 Y>F No 1000Genomes
tmp_1_16233344_C_A 100 L>M No 1000Genomes
tmp_1_16233356_G_A 104 V>I No 1000Genomes
ENSVATH13294953 105 K>N No 1000Genomes
ENSVATH13294954 142 F>V No 1000Genomes
ENSVATH04835756 147 D>E No 1000Genomes
ENSVATH04835757 153 I>K No 1000Genomes
tmp_1_16233515_G_C 157 A>P No 1000Genomes
ENSVATH00077201 159 D>N No 1000Genomes
ENSVATH00077201 159 D>Y No 1000Genomes
ENSVATH04835758 163 A>S No 1000Genomes
ENSVATH04835758 163 A>T No 1000Genomes
ENSVATH01265869 170 E>D No 1000Genomes
ENSVATH14190544 172 E>Q No 1000Genomes
ENSVATH04835760 173 Q>K No 1000Genomes
tmp_1_16233663_A_G 180 K>E No 1000Genomes
ENSVATH01265870 185 V>I No 1000Genomes
tmp_1_16233684_T_C 187 C>R No 1000Genomes
ENSVATH13294971 192 G>R No 1000Genomes
tmp_1_16233711_A_G 196 I>V No 1000Genomes
tmp_1_16233714_T_G 197 Y>D No 1000Genomes
tmp_1_16233740_G_T 205 L>F No 1000Genomes
tmp_1_16233754_C_G 210 A>G No 1000Genomes
ENSVATH13294998 215 R>H No 1000Genomes
ENSVATH01265873 217 A>T No 1000Genomes
ENSVATH00077204 219 R>K Leaf number was scored as the number of rosette leaves and the number of cauline leaves when the bolt reached 5cm [20-22c and natural light from the middle of october 2002 till march 2003. vernalized for 8wks at 4c and 8hrs daylight] Number of days required for the bolt height to reach 5cm [23c and 16hrs daylight. vernalized for 8 wks at 5c and 8hrs daylight] [EnsemblGenome] No 1000Genomes
tmp_1_16233789_C_T 222 Q>* No 1000Genomes
ENSVATH04835763 230 M>K No 1000Genomes
tmp_1_16233845_G_T 240 E>D No 1000Genomes
ENSVATH07614015 250 S>P No 1000Genomes
ENSVATH13294999 254 P>S No 1000Genomes
ENSVATH04835766 266 V>A No 1000Genomes
ENSVATH01265883 270 K>T No 1000Genomes
tmp_1_16234024_C_A 271 Q>K No 1000Genomes
tmp_1_16234031_T_G 273 I>R No 1000Genomes
ENSVATH14190578 278 S>F No 1000Genomes
tmp_1_16234048_G_A 279 G>R No 1000Genomes
ENSVATH13295001 281 L>F No 1000Genomes
ENSVATH04835767 281 L>R No 1000Genomes
ENSVATH13295002 286 D>N No 1000Genomes
tmp_1_16234327_C_G 293 S>W No 1000Genomes
ENSVATH09329927 301 L>Q No 1000Genomes
ENSVATH09329927 301 L>R No 1000Genomes
tmp_1_16234357_C_T 303 P>L No 1000Genomes
ENSVATH04835781 305 G>W No 1000Genomes
ENSVATH04835782 308 P>H No 1000Genomes
ENSVATH01265907 310 A>T No 1000Genomes
ENSVATH07614017 315 Q>* No 1000Genomes
ENSVATH07614017 315 Q>K No 1000Genomes
tmp_1_16234393_AG_GG,CG,A 315 Q>P No 1000Genomes
tmp_1_16234393_AG_GG,CG,A 315 Q>R No 1000Genomes
tmp_1_16234399_T_C 317 V>A No 1000Genomes
ENSVATH04835783 318 T>S No 1000Genomes
ENSVATH01265908 319 A>V No 1000Genomes
ENSVATH13295045 320 E>K No 1000Genomes
tmp_1_16234414_A_T 322 N>I No 1000Genomes
ENSVATH04835784 325 I>T No 1000Genomes
ENSVATH00077210 330 D>E No 1000Genomes
ENSVATH04835785 331 A>T No 1000Genomes
tmp_1_16234444_C_T 332 A>V No 1000Genomes
ENSVATH13295047 337 A>V No 1000Genomes
tmp_1_16234464_G_A 339 A>T No 1000Genomes
ENSVATH04835786 340 S>I No 1000Genomes
tmp_1_16234467_A_C 340 S>R No 1000Genomes
ENSVATH01265910 347 E>D No 1000Genomes
ENSVATH04835787 351 H>Y No 1000Genomes
tmp_1_16234521_G_A 358 V>I No 1000Genomes
ENSVATH01265912 371 L>V No 1000Genomes
ENSVATH13295050 372 L>* No 1000Genomes
ENSVATH13295049 372 L>I No 1000Genomes
ENSVATH01265915 375 A>T No 1000Genomes
ENSVATH01265917 380 C>Y No 1000Genomes
ENSVATH01265918 383 T>A No 1000Genomes
ENSVATH04835790 383 T>I No 1000Genomes
tmp_1_16234611_T_G 388 S>A No 1000Genomes
ENSVATH14190605 389 S>T No 1000Genomes
ENSVATH01265920 390 A>P No 1000Genomes
ENSVATH14190606 399 N>K No 1000Genomes
tmp_1_16234647_A_G 400 I>V No 1000Genomes
ENSVATH04835792 404 R>I No 1000Genomes
ENSVATH04835793 417 I>S No 1000Genomes
ENSVATH04835793 417 I>T No 1000Genomes
ENSVATH04835794 427 V>I No 1000Genomes
tmp_1_16234734_A_T 429 I>L No 1000Genomes
ENSVATH01265923 430 S>N No 1000Genomes
tmp_1_16234744_A_G 432 K>R No 1000Genomes
ENSVATH13295070 455 M>T No 1000Genomes
tmp_1_16235059_C_G 459 T>R No 1000Genomes
tmp_1_16235068_C_A 462 T>K No 1000Genomes
ENSVATH01265932 467 L>F No 1000Genomes
ENSVATH04835800 498 P>S No 1000Genomes
ENSVATH04835801 503 T>I No 1000Genomes
tmp_1_16235214_A_T 511 M>L No 1000Genomes
tmp_1_16235312_T_C 515 V>A No 1000Genomes
ENSVATH04835808 517 A>T No 1000Genomes
ENSVATH04835809 517 A>V No 1000Genomes
ENSVATH01265939 519 K>R No 1000Genomes
ENSVATH04835810 522 Y>* No 1000Genomes
ENSVATH04835812 531 L>I No 1000Genomes
ENSVATH04835812 531 L>V No 1000Genomes
ENSVATH04835813 533 W>L No 1000Genomes
tmp_1_16235375_C_A 536 S>Y No 1000Genomes
ENSVATH13295082 539 T>N No 1000Genomes
ENSVATH13295083 542 I>V No 1000Genomes
ENSVATH04835814 547 E>K No 1000Genomes
ENSVATH01265941 548 K>R No 1000Genomes
ENSVATH01265942 563 L>F No 1000Genomes
ENSVATH04835816 564 L>F No 1000Genomes
tmp_1_16235461_C_T 565 L>F No 1000Genomes
ENSVATH01265944 569 A>V No 1000Genomes
ENSVATH04835817 571 R>S No 1000Genomes
ENSVATH04835818 578 S>A No 1000Genomes
ENSVATH04835819 584 S>I No 1000Genomes
ENSVATH01265947 591 L>V No 1000Genomes
ENSVATH04835820 604 I>R No 1000Genomes
ENSVATH13295095 605 K>E No 1000Genomes
ENSVATH13295096 617 T>S No 1000Genomes
ENSVATH04835821 619 E>K No 1000Genomes
ENSVATH01265950 622 S>F No 1000Genomes
ENSVATH01265950 622 S>Y No 1000Genomes
ENSVATH04835822 623 K>N No 1000Genomes
ENSVATH00077215 626 D>N No 1000Genomes
tmp_1_16235650_A_T 628 M>L No 1000Genomes
ENSVATH01265955 634 P>L No 1000Genomes
ENSVATH01265956 642 K>E No 1000Genomes
tmp_1_16235778_G_A 644 V>I No 1000Genomes
ENSVATH01265958 654 Y>N No 1000Genomes
tmp_1_16235819_T_A 657 D>E No 1000Genomes
ENSVATH13295102 669 V>M No 1000Genomes
tmp_1_16235874_G_C 676 V>L No 1000Genomes
ENSVATH01265961 677 S>C No 1000Genomes
tmp_1_16235902_A_T 685 K>I No 1000Genomes
ENSVATH01265971 692 K>M No 1000Genomes
tmp_1_16236032_C_T 697 R>W No 1000Genomes
ENSVATH14190636 703 N>K No 1000Genomes
ENSVATH04835830 712 E>D No 1000Genomes
ENSVATH01265975 712 E>K No 1000Genomes
tmp_1_16236084_C_A 714 A>D No 1000Genomes
tmp_1_16236094_C_G 717 F>L No 1000Genomes

No associated diseases with P0CH31

4 regional properties for P0CH31

Type Name Position InterPro Accession
domain Cullin, N-terminal 30 - 452 IPR001373-1
domain Cullin, N-terminal 458 - 624 IPR001373-2
domain Cullin homology domain 388 - 596 IPR016158
domain Cullin protein, neddylation domain 648 - 715 IPR019559

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.

1 GO annotations of molecular function

Name Definition
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

2 GO annotations of biological process

Name Definition
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12018 CDC53 Cell division control protein 53 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q24311 Cul1 Cullin homolog 1 Drosophila melanogaster (Fruit fly) PR
Q13619 CUL4A Cullin-4A Homo sapiens (Human) PR
Q13620 CUL4B Cullin-4B Homo sapiens (Human) PR
Q13616 CUL1 Cullin-1 Homo sapiens (Human) PR
A2A432 Cul4b Cullin-4B Mus musculus (Mouse) PR
Q3TCH7 Cul4a Cullin-4A Mus musculus (Mouse) PR
Q17392 cul-4 Cullin-4 Caenorhabditis elegans PR
10 20 30 40 50 60
MATILFKVIM MKELILLEEG WSVMKTGVAK LQRILEDLSE PPFDPGQYIN LYTIIYDMCL
70 80 90 100 110 120
QQPPNDYSQE LYNKYRGVVD HYNKETVLPS MRERHGEYML RELVKRWANH KILVRWLSRF
130 140 150 160 170 180
CFYLDRFYVA RRGLPTLNDV GFTSFHDLVY QEIQSEAKDV LLALIHKERE GEQIDRTLVK
190 200 210 220 230 240
NVIDVYCGNG VGQMVIYEED FESFLLQDTA SYYSRKASRW SQEDSCPDYM LKAEECLKLE
250 260 270 280 290 300
KERVTNYLHS TTEPKLVEKV QNELLVVVAK QLIENEHSGC LALLRDDKMG DLSRMYRLYR
310 320 330 340 350 360
LIPQGLEPIA DLFKQHVTAE GNALIKQAAD AATNQDASAS QVLVRKEIEL HDKYMVYVDE
370 380 390 400 410 420
CFQKHSLFHK LLKEAFEVFC NKTVAGASSA EILATYCDNI LKTRGGSEKL SDEATEITLE
430 440 450 460 470 480
KVVNLLVYIS DKDLFAEFYR KKQARRLLFD RSGIMKEVTD ITLARELQTN FVDYLSANMT
490 500 510 520 530 540
TKLGIDFTVT VLTTGFWPSY KTTDLNLPTE MVNCVEAFKV FYGTKTNSRR LSWIYSLGTC
550 560 570 580 590 600
HILGKFEKKT MELVVSTYQA AVLLLFNNAE RLSYTEISEQ LNLSHEDLVR LLHSLSCLKY
610 620 630 640 650 660
KILIKEPMSR TISKTDTFEF NSKFTDKMRK IRVPLPPMDE RKKVVEDVDK DRRYAIDAAL
670 680 690 700 710 720
VRIMKSRKVL AHQQLVSECV EHLSKMFKPD IKMIKKRIED LINRDYLERD TENANTFKYV
A