AiPD: Autoinhibited Protein Database

Q13616

Gene name	CUL1
Protein name	Cullin-1
Names	CUL-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8454
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-105 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

32-105 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

29 structures for Q13616

Entry ID	Method	Resolution	Chain	Position	Source
1LDJ	X-ray	300 A	A	17-776	PDB
1LDK	X-ray	310 A			PDB
1U6G	X-ray	310 A	A	1-776	PDB
3RTR	X-ray	321 A	A/C/E/G	411-776	PDB
3TDU	X-ray	150 A	C/D	702-776	PDB
3TDZ	X-ray	200 A	C/D	702-776	PDB
4F52	X-ray	300 A	A/C	411-690	PDB
4P5O	X-ray	311 A	A/C	411-776	PDB
5V89	X-ray	155 A	C	702-776	PDB
6TTU	EM	370 A	C	1-776	PDB
6WCQ	EM	850 A	D	1-434	PDB
7B5L	EM	380 A	C	1-776	PDB
7B5M	EM	391 A	C	1-776	PDB
7B5N	EM	360 A	C	1-776	PDB
7B5R	EM	380 A	C	1-776	PDB
7B5S	EM	360 A	C	1-776	PDB
7Z8R	EM	270 A	C	1-776	PDB
7Z8T	EM	300 A	C	1-776	PDB
7Z8V	EM	270 A	C	1-776	PDB
7ZBW	EM	350 A	C	1-776	PDB
7ZBZ	EM	310 A	C	1-776	PDB
8CAF	X-ray	266 A	E/H	698-776	PDB
8CDJ	EM	340 A	C	1-776	PDB
8CDK	EM	332 A	C	1-776	PDB
8OR0	EM	310 A	A	1-776	PDB
8OR2	EM	320 A	A	1-776	PDB
8OR3	EM	290 A	A	1-776	PDB
8OR4	EM	380 A	A	1-776	PDB
AF-Q13616-F1	Predicted				AlphaFoldDB

244 variants for Q13616

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs746247997 CA4547055	2	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA369929892 rs1345891356	4	T>I		No	ClinGen TOPMed gnomAD
CA369929893 rs1345891356	4	T>N		No	ClinGen TOPMed gnomAD
CA4547058 rs748809924	5	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4547057 rs780747223	5	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1239708834 CA369929900	6	S>N		No	ClinGen gnomAD
rs1350913287 CA369929916	8	N>I		No	ClinGen gnomAD
CA369929923 rs1563152499	9	P>S		No	ClinGen Ensembl
CA4547061 rs761308648	10	H>N		No	ClinGen ExAC gnomAD
TCGA novel	10	H>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772982147 CA4547063	13	K>R		No	ClinGen ExAC gnomAD
rs1189777955 CA369929959	14	Q>H		No	ClinGen gnomAD
CA369929964 rs1267128009	15	I>T		No	ClinGen gnomAD
CA4547065 rs139459592	22	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs968798254 CA169030036	23	D>Y		No	ClinGen gnomAD
TCGA novel	25	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA169030060 rs868836509	27	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	28	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs978842867 CA169030062	29	Q>R		No	ClinGen Ensembl
rs1390951361 CA369930066	30	Q>R		No	ClinGen gnomAD
TCGA novel	31	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1366683687 CA369930093	34	R>Q		No	ClinGen gnomAD
CA369930091 rs764038122	34	R>W		No	ClinGen ExAC TOPMed gnomAD
CA169030066 rs879040925	39	K>*		No	ClinGen Ensembl
rs1265190217 CA369930163	44	E>K		No	ClinGen gnomAD
rs1481189304 CA369930171	45	L>I		No	ClinGen gnomAD
CA169048463 rs902254876	51	N>D		No	ClinGen TOPMed
CA169048483 rs779312688	57	H>N		No	ClinGen Ensembl
rs1397876437 CA369930728	60	N>H		No	ClinGen gnomAD
rs750624124 CA4547090	62	A>T		No	ClinGen ExAC gnomAD
CA4547091 rs756434421	62	A>V		No	ClinGen ExAC gnomAD
rs766780739 CA4547092	63	R>Q		No	ClinGen ExAC gnomAD
CA369930767 rs1340683303	66	G>E		No	ClinGen TOPMed gnomAD
rs1364353702 CA369930781	68	P>L		No	ClinGen TOPMed
CA4547096 rs375794200	70	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA4547097 rs757956155	72	S>L		No	ClinGen ExAC TOPMed gnomAD
CA369930841 rs1287984477	77	T>I		No	ClinGen TOPMed
rs777290710 CA4547098	78	P>A		No	ClinGen ExAC gnomAD
CA4547099 rs777290710	78	P>S		No	ClinGen ExAC gnomAD
CA369930846 rs1208138419	79	G>R		No	ClinGen TOPMed gnomAD
CA4547100 rs370437035	82	Q>E		No	ClinGen ESP ExAC gnomAD
rs1012140487 CA169048607	91	R>Q		No	ClinGen TOPMed gnomAD
rs1191816111 CA369930976	97	K>N		No	ClinGen gnomAD
CA369930979 rs1350257760	98	N>Y		No	ClinGen TOPMed
CA4547101 rs776233411	99	Y>C		No	ClinGen ExAC gnomAD
rs1421172004 CA369930986	99	Y>H		No	ClinGen gnomAD
rs1173080224 CA369930994	100	L>S		No	ClinGen gnomAD
rs546220050 CA4547102	102	N>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	103	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4547118 rs746537446	109	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	112	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs912856358 CA169050870	113	E>G		No	ClinGen TOPMed
rs1310697321 CA369931110	114	S>T		No	ClinGen gnomAD
CA369931117 rs1238150632	115	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA369931113 rs1379196085	115	V>I		No	ClinGen gnomAD
rs780965142 CA4547120	117	K>I		No	ClinGen ExAC gnomAD
rs112964248 CA169050878	119	Y>C		No	ClinGen Ensembl
CA169050882 rs896282269	125	D>H		No	ClinGen TOPMed
CA169050886 rs896282269	125	D>Y		No	ClinGen TOPMed
CA369931200 rs1192915299	127	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA169050890 rs535567339	132	V>G		No	ClinGen 1000Genomes
CA169050894 rs201555827	140	L>P		No	ClinGen 1000Genomes
CA369931331 rs1297726612 COSM452564	146	R>C	Variant assessed as Somatic; impact. endometrium breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
TCGA novel	152	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200692499 CA169050917	158	E>A		No	ClinGen Ensembl
COSM1087020 rs760900206 CA369931440	161	S>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4547127 rs760900206	161	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1483290618 CA369931725	163	A>V		No	ClinGen gnomAD
rs1485114214 CA369931793	169	D>E		No	ClinGen TOPMed gnomAD
CA169052191 rs932915000	169	D>N		No	ClinGen Ensembl
CA4547157 rs764554309	175	L>V		No	ClinGen ExAC gnomAD
CA369931995 rs1358790133	181	N>S		No	ClinGen gnomAD
TCGA novel	182	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4547182 rs200013850	196	I>L		No	ClinGen ExAC gnomAD
CA4547204 rs759209209	213	L>M		No	ClinGen ExAC gnomAD
CA369932508 rs1323876230	224	T>A		No	ClinGen gnomAD
CA169052813 rs1053588012	224	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1219738962 CA369932533	226	T>I		No	ClinGen gnomAD
TCGA novel	229	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369932622 rs1584796859	233	E>G		No	ClinGen Ensembl
CA169052824 rs74934754	237	L>F		No	ClinGen Ensembl
rs1023480812 CA169052820	237	L>W		No	ClinGen TOPMed
TCGA novel	237	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1201111608 CA369932729	243	F>I		No	ClinGen gnomAD
TCGA novel	245	T>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752534699 CA4547206	248	S>R		No	ClinGen ExAC gnomAD
rs764071543 CA4547208	256	P>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	267	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775057054 CA369707382	267	R>H		No	ClinGen ExAC gnomAD
rs775057054 CA4547226	267	R>P		No	ClinGen ExAC gnomAD
CA369707385 rs1176100705	268	L>V		No	ClinGen gnomAD
rs368571591 CA168859990	269	L>R		No	ClinGen ESP
CA369707400 rs1311947691	270	E>D		No	ClinGen gnomAD
CA369707406 rs1584800895	271	E>G		No	ClinGen Ensembl
rs1230503242 CA369707410	272	Q>K		No	ClinGen TOPMed
CA369707433 rs1584800902	275	V>G		No	ClinGen Ensembl
rs1584800909 CA369707447	277	V>G		No	ClinGen Ensembl
rs1004256867 CA168860006	281	E>K		No	ClinGen Ensembl
rs1037111268 CA168860015	282	S>G		No	ClinGen Ensembl
rs1341513199 CA369707491	283	T>I		No	ClinGen gnomAD
TCGA novel	284	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4547228 rs763757566	285	D>H		No	ClinGen ExAC
CA369707526 rs1563163316	288	A>G		No	ClinGen Ensembl
rs1339244491 CA369707586	297	E>K		No	ClinGen gnomAD
rs765699461 CA168860065	305	T>A		No	ClinGen Ensembl
rs1287095638 CA369707686	310	L>V		No	ClinGen gnomAD
TCGA novel	312	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA168860075 rs996061394	313	A>S		No	ClinGen Ensembl
rs1270169632 CA369707774	320	G>E		No	ClinGen TOPMed
rs1584801715 CA369707779	321	R>C		No	ClinGen Ensembl
CA369707780 rs1189978345 COSM205829	321	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1310175647 CA369707783 CA369707785	322	M>L		No	ClinGen gnomAD
rs1351484109 CA369707804	324	N>S		No	ClinGen gnomAD
CA4547250 rs760633181	330	Q>L		No	ClinGen ExAC gnomAD
TCGA novel	339	L>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1441124789 CA369707944	345	H>D		No	ClinGen gnomAD
rs754321883 CA168860976	348	G>V		No	ClinGen Ensembl
rs902742776 CA369708001	353	E>A		No	ClinGen TOPMed
CA168860986 rs902742776	353	E>G		No	ClinGen TOPMed
rs1283415610 CA369708015	355	C>G		No	ClinGen TOPMed
CA4547253 rs148771366	358	A>S		No	ClinGen ESP ExAC TOPMed
CA4547294 rs750720092	365	M>I		No	ClinGen ExAC TOPMed gnomAD
CA168877067 rs994348862	370	V>L		No	ClinGen TOPMed gnomAD
CA369708714 rs994348862	370	V>M		No	ClinGen TOPMed gnomAD
CA168877079 rs17853287	375	K>R		No	ClinGen Ensembl
TCGA novel	376	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1235772782 CA369708774	378	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	380	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	382	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755440894 CA4547298	383	S>C		No	ClinGen ExAC gnomAD
CA369708811 rs1378083870	384	A>T		No	ClinGen TOPMed
CA4547299 rs778333921	385	F>L		No	ClinGen ExAC gnomAD
CA4547300 rs752259434	386	N>S		No	ClinGen ExAC gnomAD
rs758044206 CA4547301	387	N>S		No	ClinGen ExAC TOPMed gnomAD
rs777447474 CA168877112	388	D>E		No	ClinGen ExAC TOPMed gnomAD
CA168877113 rs753880174	389	A>T		No	ClinGen Ensembl
CA4547305 rs79484500	394	A>G		No	ClinGen ExAC gnomAD
rs76864767 CA168877120	396	D>Y		No	ClinGen Ensembl
rs780187389 CA4547327	401	R>H		No	ClinGen ExAC gnomAD
rs749259569 CA4547328	404	N>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772237633 CA4547329	405	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA369708970 rs1337343665	406	N>S		No	ClinGen TOPMed gnomAD
CA4547331 rs747191601	407	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	410	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs539058564 CA4547333	411	M>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
TCGA novel	423	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	424	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	431	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4547354 rs770108110	445	T>A		No	ClinGen ExAC
CA369709311 rs1233861672	452	V>I		No	ClinGen gnomAD
rs1225307892 CA369709323	453	F>L		No	ClinGen gnomAD
rs1214199379	455	Y>*		No	gnomAD
CA369709339 rs1254354937	455	Y>*		No	ClinGen gnomAD
CA369709341 rs1466701882	456	I>L		No	ClinGen gnomAD
TCGA novel	463	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1007180929 CA168879552	464	K>N		No	ClinGen Ensembl
rs973384269 CA168879559	466	Y>F		No	ClinGen TOPMed
rs776344569 CA168879557	466	Y>H		No	ClinGen Ensembl
TCGA novel	466	Y>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1329606353 CA369709490	476	H>P		No	ClinGen gnomAD
CA369709499 rs1337802806	477	Q>R		No	ClinGen gnomAD
rs762413475 CA4547376	483	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1294881290 CA369709633	494	Q>K		No	ClinGen gnomAD
TCGA novel	499	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369709706 rs1340788094	504	L>V		No	ClinGen gnomAD
rs1273553414 CA369709762	511	I>T		No	ClinGen gnomAD
rs749545118 CA4547390	512	G>D		No	ClinGen ExAC gnomAD
rs1194452175 CA369709793	516	D>H		No	ClinGen gnomAD
CA168881066 rs972329326	517	L>M		No	ClinGen TOPMed
CA369709809 rs1294472208	518	N>S		No	ClinGen TOPMed
rs772840982 CA4547395	522	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	526	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA369709890 rs1563169853	529	E>G		No	ClinGen Ensembl
CA4547399 rs759266941	530	P>H		No	ClinGen ExAC gnomAD
rs776376224 CA4547398	530	P>S		No	ClinGen ExAC gnomAD
TCGA novel	540	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	542	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA168882202 rs17855577	550	S>F		No	ClinGen Ensembl
rs151286359 CA4547422	552	T>I		No	ClinGen ESP ExAC TOPMed
TCGA novel	552	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	553	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369272126 CA168882761	561	R>H		No	ClinGen ESP
rs767552872 CA4547440	567	T>I		No	ClinGen ExAC gnomAD
rs982169904 CA369710202	571	A>P		No	ClinGen gnomAD
rs982169904 CA168882826	571	A>S		No	ClinGen gnomAD
rs1211952562 CA369710216	573	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs142906551 CA4547442	573	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs765252536 CA4547444	577	R>*		No	ClinGen ExAC gnomAD
COSM1087027 rs758702023 CA4547445	580	T>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	581	W>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4547447 rs752032968	581	W>*		No	ClinGen ExAC gnomAD
rs200852688 CA168882894	588	G>A		No	ClinGen 1000Genomes
rs1236199581 CA369710337	591	V>I		No	ClinGen TOPMed gnomAD
rs201213491 CA168882896	592	T>P		No	ClinGen ExAC gnomAD
rs201213491 CA4547450	592	T>S		No	ClinGen ExAC gnomAD
rs1584820852 CA369710395	599	Y>H		No	ClinGen Ensembl
CA369710397 rs1348238404	599	Y>S		No	ClinGen gnomAD
rs1236894600 CA369710445	604	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA168885195 rs1017360209	609	A>S		No	ClinGen Ensembl
rs768981099 CA4547482	610	I>V		No	ClinGen ExAC gnomAD
CA168885209 rs761975125	613	Q>H		No	ClinGen ExAC gnomAD
TCGA novel	614	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA168885232 rs199545066	616	T>A		No	ClinGen 1000Genomes
CA168885238 COSM1087028 rs997347716	616	T>M	Variant assessed as Somatic; 4.63e-05 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA4547487 rs761236642	618	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	620	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4547488 rs766907724	622	V>L		No	ClinGen ExAC
rs754435224 CA4547490	627	D>E		No	ClinGen ExAC gnomAD
rs1315677008 CA369710620	630	Q>R		No	ClinGen TOPMed
CA369710664 rs1344797871	634	D>V		No	ClinGen gnomAD
CA168889517 rs1052381286	635	I>M		No	ClinGen TOPMed
CA4547515 rs140378495	637	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA369710792 rs1203503228	651	L>F		No	ClinGen gnomAD
rs1251498342 CA369710795	652	E>Q		No	ClinGen gnomAD
rs761564930 CA369710816	654	E>D		No	ClinGen ExAC TOPMed gnomAD
CA369710831 rs1393145921	656	A>V		No	ClinGen gnomAD
rs1366801810 CA369710896	665	P>L		No	ClinGen gnomAD
rs1472545470 CA369710908	667	T>N		No	ClinGen TOPMed gnomAD
rs767366101 CA4547535	669	I>T		No	ClinGen ExAC TOPMed
CA369710928 rs1451120486	670	K>I		No	ClinGen gnomAD
CA4547537 rs756084602	671	L>F		No	ClinGen ExAC gnomAD
rs200674332 CA369710944	672	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA369710938 rs1428028325	672	Y>N		No	ClinGen gnomAD
CA4547539 rs753835928	673	L>V		No	ClinGen ExAC gnomAD
TCGA novel	674	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781441428 CA4547564	682	V>A		No	ClinGen ExAC gnomAD
TCGA novel	685	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	691	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4547567 rs780476210	693	K>R		No	ClinGen ExAC gnomAD
CA168895078 rs34787741	698	T>P		No	ClinGen Ensembl
rs1159726594 CA369711165	701	K>R		No	ClinGen gnomAD
rs1251072526 CA369711178	703	I>V		No	ClinGen TOPMed gnomAD
CA168895895 rs754478318	719	M>T		No	ClinGen Ensembl
TCGA novel	719	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759426268 CA4547595	721	M>L		No	ClinGen ExAC gnomAD
rs1584828702 CA369711343	724	V>G		No	ClinGen Ensembl
rs868117336 CA168895925	729	Q>R		No	ClinGen Ensembl
CA4547598 rs762885752 COSM1448965	733	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1181287202 CA369711419	736	T>P		No	ClinGen gnomAD
rs1365947639 CA369711532	751	K>R		No	ClinGen gnomAD
TCGA novel	752	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765684261 CA4547624	765	V>L		No	ClinGen ExAC gnomAD
TCGA novel	768	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4547625 rs143079007	773	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA

No associated diseases with Q13616

4 regional properties for Q13616

Type	Name	Position	InterPro Accession
domain	Cullin, N-terminal	63 - 660	IPR001373
conserved_site	Cullin, conserved site	732 - 759	IPR016157
domain	Cullin homology domain	404 - 632	IPR016158
domain	Cullin protein, neddylation domain	688 - 753	IPR019559

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cullin-RING ubiquitin ligase complex	Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
Parkin-FBXW7-Cul1 ubiquitin ligase complex	A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
SCF ubiquitin ligase complex	A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

2 GO annotations of molecular function

Name	Definition
protein-macromolecule adaptor activity	The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

8 GO annotations of biological process

Name	Definition
animal organ morphogenesis	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
G1/S transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
intrinsic apoptotic signaling pathway	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
protein K48-linked ubiquitination	A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
protein monoubiquitination	Addition of a single ubiquitin group to a protein.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q12018	CDC53	Cell division control protein 53	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q24311	Cul1	Cullin homolog 1	Drosophila melanogaster (Fruit fly)	PR
Q13619	CUL4A	Cullin-4A	Homo sapiens (Human)	PR
Q13620	CUL4B	Cullin-4B	Homo sapiens (Human)	PR
P0CH31	At1g43140	Putative cullin-like protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSSTRSQNPH	GLKQIGLDQI	WDDLRAGIQQ	VYTRQSMAKS	RYMELYTHVY	NYCTSVHQSN
70	80	90	100	110	120
QARGAGVPPS	KSKKGQTPGG	AQFVGLELYK	RLKEFLKNYL	TNLLKDGEDL	MDESVLKFYT
130	140	150	160	170	180
QQWEDYRFSS	KVLNGICAYL	NRHWVRRECD	EGRKGIYEIY	SLALVTWRDC	LFRPLNKQVT
190	200	210	220	230	240
NAVLKLIEKE	RNGETINTRL	ISGVVQSYVE	LGLNEDDAFA	KGPTLTVYKE	SFESQFLADT
250	260	270	280	290	300
ERFYTRESTE	FLQQNPVTEY	MKKAEARLLE	EQRRVQVYLH	ESTQDELARK	CEQVLIEKHL
310	320	330	340	350	360
EIFHTEFQNL	LDADKNEDLG	RMYNLVSRIQ	DGLGELKKLL	ETHIHNQGLA	AIEKCGEAAL
370	380	390	400	410	420
NDPKMYVQTV	LDVHKKYNAL	VMSAFNNDAG	FVAALDKACG	RFINNNAVTK	MAQSSSKSPE
430	440	450	460	470	480
LLARYCDSLL	KKSSKNPEEA	ELEDTLNQVM	VVFKYIEDKD	VFQKFYAKML	AKRLVHQNSA
490	500	510	520	530	540
SDDAEASMIS	KLKQACGFEY	TSKLQRMFQD	IGVSKDLNEQ	FKKHLTNSEP	LDLDFSIQVL
550	560	570	580	590	600
SSGSWPFQQS	CTFALPSELE	RSYQRFTAFY	ASRHSGRKLT	WLYQLSKGEL	VTNCFKNRYT
610	620	630	640	650	660
LQASTFQMAI	LLQYNTEDAY	TVQQLTDSTQ	IKMDILAQVL	QILLKSKLLV	LEDENANVDE
670	680	690	700	710	720
VELKPDTLIK	LYLGYKNKKL	RVNINVPMKT	EQKQEQETTH	KNIEEDRKLL	IQAAIVRIMK
730	740	750	760	770
MRKVLKHQQL	LGEVLTQLSS	RFKPRVPVIK	KCIDILIEKE	YLERVDGEKD	TYSYLA