Q24311

PR
Gene name
Cul1 (cul-1, lin19, CG1877)
Protein name
Cullin homolog 1
Names
Lin-19 homolog protein
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG1877
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

400-469 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q24311

Entry ID Method Resolution Chain Position Source
AF-Q24311-F1 Predicted AlphaFoldDB

No variants for Q24311

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q24311

No associated diseases with Q24311

No regional properties for Q24311

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q24311

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • In the spermatid, colocalizes with ntc at the actin-based individualization complex and the cystic bulge
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

3 GO annotations of molecular function

Name Definition
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.

17 GO annotations of biological process

Name Definition
negative regulation of antimicrobial peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of hippo signaling Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
negative regulation of peptidoglycan recognition protein signaling pathway Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway.
negative regulation of phosphatidylinositol 3-kinase signaling Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
negative regulation of protein kinase B signaling Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
negative regulation of smoothened signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
positive regulation of neuron remodeling Any process that activates or increases the frequency, rate or extent of neuron remodeling.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
positive regulation of protein ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
positive regulation of synaptonemal complex assembly Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly.
protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
protein K11-linked ubiquitination A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12018 CDC53 Cell division control protein 53 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q13616 CUL1 Cullin-1 Homo sapiens (Human) PR
P0CH31 At1g43140 Putative cullin-like protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MNRSGNSQTT QKLVNLDDIW SELVEGIMQV FEHEKSLTRS QYMRFYTHVY DYCTSVSAAP
70 80 90 100 110 120
SGRSSGKTGG AQLVGKKLYD RLEQFLKSYL SELLTKFKAI SGEEVLLSRY TKQWKSYQFS
130 140 150 160 170 180
STVLDGICNY LNRNWVKREC EEGQKGIYKI YRLALVAWKG HLFQVLNEPV TKAVLKSIEE
190 200 210 220 230 240
ERQGKLINRS LVRDVIECYV ELSFNEEDTD AEQQKLSVYK QNFENKFIAD TSAFYEKESD
250 260 270 280 290 300
AFLSTNTVTE YLKHVENRLE EETQRVRGFN SKNGLSYLHE TTADVLKSTC EEVLIEKHLK
310 320 330 340 350 360
IFHTEFQNLL NADRNDDLKR MYSLVALSSK NLTDLKSILE NHILHQGTEA IAKCCTTDAA
370 380 390 400 410 420
NDPKTYVQTI LDVHKKYNAL VLTAFNNDNG FVAALDKACG KFINSNVVTI ANSASKSPEL
430 440 450 460 470 480
LAKYCDLLLK KSSKNPEDKE LEDNLNQVMV VFKYIEDKDV FQKYYSKMLA KRLVNHTSAS
490 500 510 520 530 540
DDAEAMMISK LKQTCGYEYT VKLQRMFQDI GVSKDLNSYF KQYLAEKNLT MEIDFGIEVL
550 560 570 580 590 600
SSGSWPFQLS NNFLLPSELE RSVRQFNEFY AARHSGRKLN WLYQMCKGEL IMNVNRNNSS
610 620 630 640 650 660
TYTLQASTFQ MSVLLQFNDQ LSFTVQQLQD NTQTQQENLI QVLQILLKAK VLTSSDNENS
670 680 690 700 710 720
LTPESTVELF LDYKNKKRRI NINQPLKTEL KVEQETVHKH IEEDRKLLIQ AAIVRIMKMR
730 740 750 760 770
KRLNHTNLIS EVLNQLSTRF KPKVPVIKKC IDILIEKEYL ERMEGHKDTY SYLA